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Rare missense variant (R251G) on APOE counterbalances the Alzheimer’s disease risk associated with APOE-ε4

Yann Le Guen - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Alzheimer's disease

N/A

- Polygenic risk score for Alzheimer’s disease and APOE ε4 status in relation to cognitive decline: a population-based study of individuals followed over 16 years.

Jenna Najar - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Alzheimer's disease

N/A

- Clinical and genetic features of Lewy body pathology in autosomal dominant and sporadic Alzheimer disease

Jonathan Vöglein - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Alzheimer's disease

N/A

Analysis of the genetics of Lewy Body Dementia, Alzheimer's Disease and Parkinson's Disease reveal both shared and distinct mechanisms for the diseases.

Maryam Shoai - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Alzheimer's disease

N/A

- Comparison of degu (Octodon degus), Naked Mole Rat, Mouse and Human genomes identified common hallmarks of aging and Alzheimer's Disease

Patricia Cogram - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Alzheimer's disease

N/A

- GMNC risk alleles in individuals with Alzheimer’s disease are associated with cerebrospinal fluid concentrations of proteins involved in neuronal plasticity and blood brain barrier function

Pieter Jelle Visser - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Alzheimer's disease

N/A

Influence of apolipoprotein E (apoE) on ADAM10 secretase in cerebrospinal fluid of older adults with Alzheimer's disease

Renata Valle Pedroso - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Alzheimer's disease

N/A

Levels of astrocyte-derived glial fibrillary acidic protein (GFAP) and S100 calcium-binding protein B (S100B) in the cerebrospinal fluid within the early stages of Alzheimer´s Disease

Arda Can Cetindag - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Mild cognitive impairment

N/A

- Harmonization of neuropathology measures and characterization of neuropathological burden across population-based autopsy samples

Emma Nichols - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Lewy body dementia

N/A

- Cortisol, cognition, and Alzheimer’s disease biomarkers among memory clinic patients

Jasper Holleman - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Mild cognitive impairment

N/A

Effects of blood pressure lowering for the prevention of dementia: meta-analysis of individual patient data from five seminal randomised controlled trials involving 28008 participants

Ruth Peters - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Dementia

N/A

The clinical development history of gantenerumab, a subcutaneous anti-Aβ monoclonal antibody for early Alzheimer’s disease: Building on lessons from the past and paving a path for the future

Rachelle S. Doody - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Infectious Diseases (ID)

Alzheimer's disease

Gantenerumab

Automated detection of lacunar infarcts from MRI images

Jyrki Lötjönen - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Dementia

N/A

Genetic contribution to grey matter network disruptions and Alzheimer disease cerebrospinal fluid markers

Ellen Dicks - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Alzheimer's disease

N/A

Hypothalamic Volumes Predict Sleep Dysfunction in Genetic Frontotemporal Dementia

Paul T. Best - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Frontotemporal dementia

N/A

Methodology dependent sex differences in Aβ-PET measured with SUVR

William Coath - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

N/A

Florbetapir

White matter hyperintensities in the corpus callosum are associated with beta-amyloid, neurodegeneration and cognitive performance

Miranka Wirth - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

White matter hyperintensities

N/A

- Polygenic determinants of White Matter Hyperintensities and sex-specific genetic profiles in the Alzheimer’s continuum

Patricia Genius - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

White matter hyperintensities

N/A

- Different atrophy profiles detected in AD patients who carry APOE4 versus non-carriers: An ENIGMA-VBM Multicohort Analysis (N=1,893)

Priya Rajagopalan - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Alzheimer's disease

N/A

Conversations and decision-making about nutrition and hydration for people with severe dementia in acute hospitals: a qualitative study

Kanthee Anantapong - Alzheimer's Association International Conference (AAIC) , 2022

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Dementia

N/A

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