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: Rare missense variant (R251G) on APOE counterbalances the Alzheimer’s disease risk associated with APOE-ε4

Researchers

Presenter

  • Yann Le Guen

Principal Investigators

  • Benjamin Grenier-Boley

  • Itziar de Rojas

  • Atahualpa Castillo

  • Iris E Jansen

  • Aude Nicolas

  • Céline Bellenguez

  • Carolina Dalmasso

  • Fahri Küçükali

  • Sarah J Eger

  • Victoria Álvarez-Martínez

  • Beatrice Arosio

  • Luisa Benussi

  • Anne Boland

  • Barbara Borroni

  • María J. Bullido

  • Paolo Caffarra

  • Jordi Clarimón

  • Delphine Daian

  • Antonio Daniele

  • Stéphanie Debette

  • Jean-François Deleuze

  • Martin Dichgans

  • Carole Dufouil

  • Emrah Duzel

  • Daniela Galimberti

  • Jose María García-Alberca

  • Pablo García-González

  • Vilmantas Giedraitis

  • Timo Grimmer

  • Caroline Graff

  • Edna Grunblatt

  • Olivier Hanon

  • Lucrezia Hausner

  • Stefanie Heilmann-Heimbach

  • Henne Holstege

  • Jakub Hort

  • Deckert Jurgen

  • Teemu Kuulasmaa

  • Aad van der Lugt

  • Carlo Masullo

  • Patrizia Mecocci

  • Shima Mehrabian

  • Alexandre de Mendonça

  • Mercè Boada

  • Pablo Mir

  • Susanne Moebus

  • Fermin Moreno

  • Benedetta Nacmias

  • Gaël Nicolas

  • Goran Papenberg

  • Lucilla Parnetti

  • Florence Pasquier

  • Pau Pastor

  • Oliver Peters

  • Yolande A.L. Pijnenburg

  • Gerard Piñol-Ripoll

  • Julius Popp

  • Laura Molina

  • Raquel Puerta

  • Jordi Pérez-Tur

  • Innocenzo Rainero

  • Inez H.G.B. Ramakers

  • Katrine Laura Rasmussen

  • Luis Miguel Real

  • Steffi G. Riedel-Heller

  • Eloy Rodríguez Rodríguez

  • José Luís Royo

  • Dan Rujescu

  • Nikolaos Scarmeas

  • Philip Scheltens

  • Norbert Scherbaum

  • Anja Schneider

  • Davide Seripa

  • Hilkka Soininen

  • Vincenzo Solfrizzi

  • Gianfranco Spalletta

  • Alessio Squassina

  • John C van Swieten

  • Raquel Sanchez-Valle

  • Thomas Tegos

  • Jesper Qvist Thomassen

  • Lucio Tremolizzo

  • Frans R.J. Verhey

  • Martin Vyhnalek

  • Jens Wiltfang

  • Zihuai He

  • Valerio Napolioni

  • Philippe Amouyel

  • Frank Jessen

  • Patrick G Kehoe

  • Cornelia M van Duijn

  • Magda Tsolaki

  • Pascual Sanchez-Juan

  • Kristel Sleegers

  • Martin Ingelsson

  • Giacomina Rossi

  • Mikko Hiltunen

  • Rebecca Sims

  • Wiesje M. van der Flier

  • Alfredo Ramirez

  • Ole Andreassen

  • Ruth Frikke-Schmidt

  • Julie Williams

  • Agustin Ruiz

  • jean-charles Lambert

  • Michael D Greicius

Medical Centers

  • Unit for Hereditary Dementia, Theme Inflammation and Aging, Karolinska University Hospital-Solna

  • Columbia University Medical Center, New York, NY

  • International Clinical Research Centre (ICRC), St. Anne’s University Hospital

  • LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen

  • Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich

  • Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital Mútua Terrassa,

  • Erasmus MC University Medical Center

  • Institute of Neurology, Catholic University of the Sacred Heart

  • Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, France., Lille, France

  • Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience

  • Institute for Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University

  • Univ. Bordeaux, INSERM, BPH, U1219

  • 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School

  • Neurology, "San Gerardo" hospital, Monza and University of Milano-Bicocca

  • Department of Epidemiology, Erasmus Medical Center

  • Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Florence, Italy

  • Hospital Universitario Central de Asturias,

  • 1st Department of Neurology, Medical school, Aristotle University of Thessaloniki

  • Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

  • Clinical Sciences and Community Health, University of Milan, Milan, Italy

  • Faculty of Medicine,University of

  • Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia

  • CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III

  • University of Bordeaux, Inserm

  • Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg

  • Department for Psychiatry and Psychotherapy, Medical Faculty, University of Cologne

  • Alzheimer's disease and other cognitive disorders unit. Service of Neurology. Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona

  • Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL)

  • Centre for Neurodegenerative disorders, Neurology unit, Department of Clinical and Experimental Sciences, University of Brescia

  • University of Perugia

  • University of Eastern Finland

  • Division of Psychological Medicine and Clinical Neurosciences, Cardiff University

  • INSERM 1172

  • Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic

  • School for Mental Health & Neuroscience

  • NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital

  • Hôpital Broca

  • Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III

  • Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic, IDIBAPS

  • VIB Center for Molecular Neurology, VIB

  • Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

  • Università Cattolica del Sacro Cuore

  • Institut du Cerveau - Paris Brain Institute - ICM

  • VIB Center for Molecular Neurology, VIB

  • Inserm U1245 / Rouen University Hospital

  • University Medical Center, University of Goettingen

  • Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau Biomedical Research Institute Sant Pau Universitat Autònoma de Barcelona, Spain

  • UK Dementia Research Institute at Cardiff University

  • Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina. Universidad de Málaga

  • Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University

  • Institute of Social Medicine, Occupational Health and Public Health (ISAP), Faculty of Medicine, University of Leipzig

  • Department of Neuroscience “Rita Levi Montalcini”, University of Torino

  • German Center for Neurodegenarative Diseases (DZNE)

  • Dept.of Public Health and Caring Sciences / Geriatrics, Uppsala University

  • Stanford University, CA

  • Centre National de Génotypage, Institut de Génomique / CEA

  • Department of Psychiatry, University of Cologne, Medical Faculty, Cologne

  • Dept.of Public Health and Caring Sciences / Geriatrics, Uppsala University

  • Clinic of Neurology, UH "Alexandrovska", Medical University - Sofia

  • Department of Neurology, University of Kentucky

  • Institut de Recerca Biomédica de Lleida (IRBLLeida)

  • Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

  • Institute of Medical Informatics, Biometry und Epidemiology, University Hospital of Essen

  • Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg

  • Maastricht University

  • Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

  • Instituto de Investigacion Sanitaria del Principado de Asturias, (ISPA), Oviedo, Spain,

  • Fondazione IRCCS Ca’ Granda, Ospedale Policlinico, Neurodegenerative Diseases Unit

  • Institute for Stroke and Dementia Research,Klinikum der Universität München,Munich,Germany

  • Centre for Cognitive Disordes and Dementia (CDCD), AUSL

  • Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga

  • Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unit, University of Bari “A. Moro

  • Department of Psychiatry, Charité – Universitätsmedizin Berlin

  • IRCCS San Giovanni di Dio Fatebenefratelli

  • Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine

  • Nuffield Department of Population Health, University of Oxford

  • Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC

  • Human Genetics, University of Bonn

  • University Hospital of Psychiatry Zürich

  • Translational Health Sciences, Bristol Medical School, University of Bristol

  • Dept. of Biomedical Sciences, University of Cagliari, Italy

  • Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, UMR1167

  • Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant

  • Neurological Tissue Bank - IDIBAPS/Hospital Clínic Barcelona

  • Alzheimer Center Amsterdam, Amsterdam UMC

  • Department of Psychiatry and Psychotherapy, University of Würzburg

  • Cardiff, School of Medicine, Cardiff University, Wales, UK

  • Klinikum rechts der Isar, Technical University of Munich, School of Medicine

  • Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation

  • Research Center and Memory Clinic. Ace Alzheimer Center Barcelona. Universitat Internacional de Catalunya

  • Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne

Locations

  • Germany

  • France

  • United States

  • Finland

  • Italy

  • Portugal

  • Turkey

  • Venezuela

  • Czech Republic

  • Spain

  • Bulgaria

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Central Nervous System (CNS)

Disease

  • Alzheimer's disease

Biomarkers

  • N/A

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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