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45280 Abstracts

A Novel Mendelian Disease of Autoimmunity caused by Mutations in a small GTPase

Michael Alexander Leney-Greene - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Blood/haematological Diseases

Thrombocytopenia

N/A

Absence of CD137L decreases mechanical hypersensitivity and functional recovery time following sciatic nerve crush

Alexa A. Wakley - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Chronic obstructive pulmonary disease

N/A

The role of innate lymphoid cells in the heart and cardiac inflammation

Hee Sun Choi - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Infectious Diseases (ID)

Diastolic dysfunction

N/A

Use of fluorescent Fab/Ab complexes and IncuCyte live-cell analysis to dynamically track cell surface markers and cell populations in mixed cultures

Gillian F. Lovell - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

IFN-lambda

Purine nucleotide metabolism regulates expression of human MICA.

Chris OCallaghan - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune inhibition

Christopher M. Rice - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

SLAMF9 promotes inflammation and resistance to Salmonella infection

Timothy James Wilson - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

STAYING ALIVE! SIGNAL PROCESSING BY NF-κB PROTECTS NKT CELLS FROM TNFR1-TRIGGERED DEATH

Amrendra Kumar - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

IL-15

The impact of target stiffness on NK cell activation

Daniel Friedman - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

Calcium Chloride

LUBAC-mediated signals in thymic epithelial cells prevent early thymic atrophy and immunodeficiency

Reema Jain - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

ZIKV-specific CD8 T cell immunity in humans is affected by DENV pre-exposure

Alba Grifoni - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Infectious Diseases (ID)

Zika virus disease

N/A

Large-scale use of knockout validation to confirm antibody specificity

Zhen Zhong - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich rheumatoid arthritis, pre-rheumatoid arthritis and systemic lupus erythematosus

Suzanne Cole - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Musculoskeletal

Lupus

daratumumab Intravenous

Real-time visualisation and quantification of Neutrophil Extracellular Traps

Gillian F. Lovell - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Obstetrics/Gynecology

Lupus

Phosphatidylserine

Intragenic transcriptional interference regulates the human immune ligand MICA.

Chris OCallaghan - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

IL-4

Development and characterization of a bovine monocyte-derived macrophage cell line

Carol G. Chitko-McKown - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

Novel MVA-based vaccine expressing influenza NP and M1 activates cross-reactive T cell responses in human nasopharynx-associated lymphoid tissue (NALT)

Suttida Puksuriwong - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Infectious Diseases (ID)

Influenza

Interferon Gamma

A critical epithelial survival axis regulated by MCL-1 maintains thymic function

Reema Jain - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Hematology-oncology disease

N/A

Glycogen synthase kinase-3 (GSK-3) inactivation compensates for the lack of CD28 in the priming of CD8+ cytotoxic T-cells: Implications for anti-PD-1 immunotherapy

Christopher E. Rudd - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Lymphomas

N/A

Alloreactive T cells develop in the very early period following human stem cell transplantation and are characterised by a range of novel features

P. Moss - American Association of Immunologists (AAI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Blood/haematological Diseases

Graft-versus-host disease

OX40L

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