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45280 Abstracts

Fibrillin-1 mutant mice (tight skin) show increased spontaneous and trauma-induced osteoarthritis development

B. Poulet - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Osteoarthritis

N/A

Cellular and molecular mechanisms of subchondral bone sclerosis in hip osteoarthritis: the potential roles of multipotential stromal cells and osteocytes

D.C. Ilas - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Osteoarthritis

Collagenase

Measuring the progression of trauma induced osteoarthritis in CCN2 deficient mice

M. Jaffa - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Osteoarthritis

Tamoxifen

Assessment of the effects of exercise on a murine model of OA

C. Huesa - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

Laser ablation machined sections permit correlative studies of hdmps by X-ray microtomography, optical and scanning electron microscopy

A. Boyde - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

CCN2 deficiency in chondrocytes does not exacerbate osteoarthritis in trauma-induced mouse models

C. Keenan - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Osteoarthritis

Tamoxifen

A combined model of destabilisation of the medial meniscus and cartilage damage accelerates osteophytogenesis in osteoarthritis

K. McCulloch - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Musculoskeletal

Osteoarthritis

N/A

Generation and phenotyping of a targeted mouse model of alkaptonuria

J.H. Hughes - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Alkaptonuria

N/A

Ubiquitin-protein ligase Ubr5 is a potent suppressor of spontaneous heterotopic ossification and articular cartilage damage

D. Mellis - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Obstetrics/Gynecology

Twin-reversed arterial perfusion

Tamoxifen

Viperin regulates chondrogenic differentiation via CXCL10 protein secretion

M.M. Steinbusch - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

Transient receptor potential cation channel (TRPC6) as a regulator of CXCR2-mediated articular cartilage homeostasis

J. Sherwood - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Musculoskeletal

Osteoarthritis

N/A

Urocortin expression in cartilage is attenuated in a non-invasive mouse model of post traumatic osteoarthritis

F. Ter Heegde - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Musculoskeletal

Osteoarthritis

N/A

A COL9A3 EXON 3 skipping mouse as novel model for multiple epiphyseal dysplasia and early-onset osteoarthritis

S. Lecci - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Musculoskeletal

Multiple epiphyseal dysplasia

N/A

Exploring and exploiting a ciliome-protease-matrix regulatory axis disturbed in osteoarthritis

I. Collins - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Musculoskeletal

Osteoarthritis

N/A

Disruption of collagen triple helix hydrogen bonding in ochronotic human cartilage in alkaptonuria observed by dynamic nuclear polarisation-enhanced solid-state nuclear magnetic resonance spectroscopy

B.P. Norman - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Alkaptonuria

N/A

Differential gene expression in ankle compared to knee cartilage: might this explain the difference in osteoarthritis prevalence?

A.S. Miller - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Musculoskeletal

Osteoarthritis

N/A

Analysis of anion channel activity in chondrocytes in vitro model of osteoarthritis

K. Kumagai - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

Musculoskeletal

Osteoarthritis

Collagenase

Ribosomal profiling and secretome analysis identify that interleukin-1B driven cytokine/chemokine release from chondrocytic cells is underpinned by differential translation

B.T. McDermott - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

Interleukin

Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy

J.G. Sykes - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

Raman spectroscopy can non-invasively distinguish between ochronotic and non-ochronotic cartilage

A.M. Taylor - Osteoarthritis Research Society International (OARSI) , 2018

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

calcium/fluoride

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