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45280 Abstracts

Central role for phosphoinositide-3-kinase gamma/delta dependent signalling in eosinophilic pulmonary inflammation driven by innate lymphoid cells

Matt Thomas - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Autoimmune (AI)

Asthma

N/A

Phosphoinositide-3-kinase gamma/delta isoform signalling defines a mixed T cell severe asthmatic endotype

Matt Thomas - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Autoimmune (AI)

Asthma

GM-CSF

Reduced expression of the transcription factor KLF4 in COPD macrophages is associated with dysfunctional differentiation

Jessica Tilman - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Chronic obstructive pulmonary disease

GM-CSF

Immortalisation of human alveolar epithelial cells to investigate the mechanistic effects of inhaled airborne materials in vitro

Alberto Katsumiti - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

Alkaline phosphatase

Decreased degranulating and mast cells in the small airway wall of COPD patients is indicative of dysfunctional immunity

Mathew Eapen - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Chronic obstructive pulmonary disease

N/A

Oxidative stress modified DAMPs reduce phagocytic capacity in COPD

Paul Kirkham - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Chronic obstructive pulmonary disease

IL-12

Volatile Organic Compounds Breathprinting of U-BIOPRED Severe Asthma smokers/ex-smokers cohort

Massimo Caruso - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Autoimmune (AI)

Asthma

N/A

Effect of surface functionalisation on the interaction of carbon nanotubes with primary human alveolar cells in vitro

Lareb Dean - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

Impaired serum opsonisation of non typeable Haemophilus influenzae in COPD and Alpha-1 Anti-Trypsin Deficiency. A potential mechanism for reduced bacterial clearance?

Georgia Walton - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Chronic obstructive pulmonary disease

Trypsin

Repeat Measurements of Complement proteins C3a and C5a in COPD patients

Thomas Southworth - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Chronic obstructive pulmonary disease

N/A

RNA-binding protein HuR inhibits the expression of sirtuin-1 in patients with COPD

Jonathan R. Baker - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Chronic obstructive pulmonary disease

N/A

Bromodomain And Extra-Terminal (BET) proteins regulate metabolic and redox function in COPD airway smooth muscle cells

Charalambos Michaeloudes - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Chronic obstructive pulmonary disease

N/A

Alpha-1 antitrypsin (AAT) polymerization in alveolar macrophages of AAT deficient individuals and in smokers

Erica Bazzan - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Alpha-1 antitrypsin (A1AT) deficiency

Alpha 1-Antitrypsin

MicroRNA-34a drives small airway fibroblast cellular senescence in COPD

Catherine Wrench - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Chronic obstructive pulmonary disease

N/A

Effect of tralokinumab on GINA control in severe, uncontrolled asthma

Christopher E. Brightling - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Autoimmune (AI)

Asthma

CAT-354

Perceived and actual control in patients with severe asthma: results from a global online survey

Paraskevi Katsaounou - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Autoimmune (AI)

Asthma

N/A

Living with severe asthma year 2016

Paraskevi Katsaounou - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Autoimmune (AI)

Asthma

N/A

Genome-wide association study of inhaled corticosteroid response in African-admixed children with asthma

Natalia Hernandez-Pacheco - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Autoimmune (AI)

Asthma

N/A

Characterisation of exacerbations of severe eosinophilic asthma (SEA) on mepolizumab compared to placebo

Rahul Shrimanker - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

Autoimmune (AI)

Asthma

Mepolizumab

Electronic monitoring devices in clinical trials – a doddle to use?

Ireti Adejumo - European Respiratory Society (ERS) , 2017

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

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