App-Quantinova.ai

Genomic prevalence analysis in TNBC patients in the Phase 2 VIOLETTE study

Joshua Armenia - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Triple-negative breast cancer

Methadone hydrochloride

HPK1, hematopoietic progenitor kinase 1, is a promising therapeutic target for cancer immunotherapy

David Ciccone - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Phase Ib/II open-label, randomized evaluation of atezolizumab + cobimetinib vs control in MORPHEUS-NSCLC (non-small cell lung cancer), MORPHEUS-PDAC (pancreatic ductal adenocarcinoma) and MORPHEUS-GC (gastric cancer)

Byoung Chul Cho - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Pancreas ductal adenocarcinoma

Atezolizumab

Updated OS and exploratory analyses of first-line (1L) atezolizumab (atezo) + carboplatin (C) + etoposide (E) in extensive-stage SCLC (ES-SCLC)

Leora Horn - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Small cell lung cancer

Atezolizumab

APOBEC/ADAR aberrations are potentially implicated in certain pancancer hypermutation patterns

Ahmadreza Niavarani - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

A preclinical model using perfusion air culture of tumor tissue slices for personalized medicine

Meng Dong - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Infectious Diseases (ID)

Tuberculosis

Cisplatin

Olaparib antiproliferative effect in pancreatic cancer and correlation with the response to other anticancer agents

Elisabetta Leo - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Metastatic pancreatic adenocarcinoma

Gemcitabine

First in human study with EOS100850, a novel potent A2A antagonist, shows excellent tolerance and clinical benefit in immune resistant advanced cancers

Laurence Buisseret - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Endometrial Cancer

Pembrolizumab

Live biotherapeutic MRx0518 as a modulator of immune responses in intestinal tissue and breast tumor microenvironment

Jean-Francois Mirjolet - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Mammary carcinoma

N/A

Bispecific antibody drug conjugates targeting CD7 and CD33 for the treatment of acute myeloid leukemia

Richard Bethell - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute myelocytic leukemia

Gemtuzumab ozogamicin

Lrg1 blockade modulates the tumor immune microenvironment and improves the efficacy of cancer therapeutics

Carlotta Camilli - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Characterization of ATM inhibitor (AZD1390) distribution and pharmacodynamic changes in brain and glioblastoma in preclinical models to inform on mechanism of action

Lenka Oplustil O'Connor - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Ataxia telangiectasia

N/A

Using CRISPR/Cas9 to study resistance to glutaminase inhibition

Aleksandra M. Raczka - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Renal cell carcinoma

Glutamine

PLAP (placental alkaline phosphatase)-CAR-T cells specifically target colorectal cancer

Vita M. Golubovskaya - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Colorectal Cancer

Alkaline phosphatase

Identification of novel CDK12 inhibitors that synergize with PARP inhibition through induction of ‘BRCAness’ phenotype

Edward K. Ainscow - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Ewing's sarcoma

Olaparib

The origin and contribution of the tumor stroma in colorectal cancer

Hiroki Kobayashi - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Colorectal Cancer

N/A

A randomized, double-blind, placebo-controlled, phase 3 study of pembrolizumab in combination with gemcitabine and cisplatin for the treatment of advanced biliary tract carcinoma

Richard S. Finn - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Advanced biliary tract carcinoma

Pembrolizumab

Homologous recombination repair gene mutations (HRRm) in metastatic pancreatic cancer (mPaC) tumors

Zhongwu Lai - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Metastatic pancreatic adenocarcinoma

Methadone hydrochloride

Mechanistic differentiation of targeted DDR agent combinations

Josep V. Forment - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Triple-negative breast cancer

Olaparib

Spatially-segmented single-cell transcriptomics by diffusional accessibility to a small-molecule dye

David B. Morse - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

High grade serous ovarian cancer

N/A

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