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6168 : Characterization of ATM inhibitor (AZD1390) distribution and pharmacodynamic changes in brain and glioblastoma in preclinical models to inform on mechanism of action

Researchers

Presenter

  • Lenka Oplustil O'Connor

Principal Investigators

  • Gregory Hamm

  • Maria Udriste

  • Stephanie Ling

  • Joanne Wilson

  • Steve Durant

  • Gareth Hughes

  • Sabina Cosulich

  • Wenlin Shao

  • Martin Pass

  • Gemma Jones

  • Andrew Pierce

  • Richard Goodwin

  • Mark O'Connor

  • Carl Barrett

  • Elizabeth Harrington

Medical Centers

  • N/A

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Central Nervous System (CNS)

Disease

  • Ataxia telangiectasia

  • Glioblastoma

  • Seizures sensorineural deafness ataxia mental retardation electrolyte imbalance

Biomarkers

  • Microsatellite instability

  • Ataxia-telangiectasia mutated

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • Pharmacokinetics

  • Pharmacodynamics

Phase

  • I

Study Id's

  • NCT03423628

Sponsors

  • N/A

Result

  • N/A

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