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Candesartan prevents cisplatin-induced vascular toxicity by attenuating oxidative stress, inflammation, and necroptosis and upregulating NRF2/HO-1 signaling in RAT AORTA

Ayman Mahmoud - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Heme oxygenase 1 deficiency

candesartan (tablet)

SD-208 reverts hypertrophic cardiomyopathy myofibroblasts into fibroblasts and affects small extracellular vesicle secretion

Georgie Thompson - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Cardiovascular (CVS)

Hypertrophic cardiomyopathy

SD-208

Single-nucleus sequencing of doxorubicin-treated mouse hearts reveals disease progression of cardiomyocytes

Yue Qin - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

N/A

Doxorubicin

The role of BACE1 in cerebrovascular disease

Hannah Taylor - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Alzheimer's disease

Nitric oxide

The role of CTA radiotranscriptomic phenotyping in understanding the vascular effects of Lp(a) in advanced atherosclerosis

Cheng Xie - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Cardiovascular (CVS)

Coronary Artery Disease

N/A

SIRT1: a novel regulator of integrin αiibβ3 and actin cytoskeleton dynamics in platelets

Maria Blanco - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Blood/haematological Diseases

Ischemia-reperfusion injury

Fibrinogen (IV)

Targeting BACE1 to improve angiogenesis in type 2 diabetes

Eva Clavane - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Endocrine/metabolic Diseases (ME)

Type 2 diabetes mellitus

Occlusal-HP Topical

Characterising variations in the composition of native extracellular matrix in a model of arterial thrombosis

Amelia Drysdale - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Blood/haematological Diseases

Venous thrombosis

N/A

Monocyte response after elective percutaneous coronary intervention

Ioannis Merinopoulos - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Nephrology

Coronary Artery Disease

N/A

Understanding the role of cardiac fibrosis in the development and treatment of heart failure using molecular imaging probes and novel therapeutics

KONSTANTINA AMOIRADAKI - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Cardiovascular (CVS)

Cardiac fibrosis

N/A

Transcription factors MYC and USF1 drive chronic macrophage dysfunction in ageing

Charlotte Moss - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Cardiovascular (CVS)

Coronary Artery Disease

N/A

A comparative genomics approach reveals the interplay between epigenomic enhancer conservation and common genetic variation in the heart

Stephanie Frost - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

N/A

Calcium signalling modulates VSMC response to matrix stiffness in ageing and disease

Finn Wostear - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Angiology

Calcified vascular disease

Angiotensin II

A new collagen III-specific MRI imaging probe to assess cardiac fibrosis

Nadia Chaher - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Endocrine/metabolic Diseases (ME)

Myocardial infarction

Gadavist

Understanding the adaptive immune response in heart failure post-myocardial infarction

Adam Lokman - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Cardiovascular (CVS)

Post-myocardial infarction

N/A

A fully automated vulnerable plaque classifier for oct using co-registered histological images and transfer learning learning.

Rob Krams - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

N/A

Blood vessel organoids derived from diabetic patients revealed impaired function based on a subpopulation of endothelial cells

Hojjat Naderi-Meshkin - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Endocrine/metabolic Diseases (ME)

Diabetes

N/A

High sensitivity C-reactive protein at baseline predicts cardiovascular outcomes at 20-year follow-up in the ascot legacy study

Adam Hartley - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

Endocrine/metabolic Diseases (ME)

Hypertension

Atorvastatin

Genetically-proxied low density lipoprotein cholesterol lowering via PCSK9-inhibitor drug targets and risk of congenital malformations

Maddalena Ardissino - British Cardiovascular Society (BCS) , 2023

Therapeutic Area

Disease

Drug/Treatment

N/A

Anorectal Cream

No difference in risk of myocardial infarction among patients receiving either IL6 or TNF inhibitors for rheumatoid arthritis

Zixing Tian - British Society for Rheumatology (BSR) , 2023

Therapeutic Area

Disease

Drug/Treatment

Cardiovascular (CVS)

Myocardial infarction

N/A

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