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Targeting TRBC1 and 2 for the treatment of T cell lymphomas

Mathieu Ferrari - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

T-cell lymphoma

N/A

Ultra-high throughput functional screen

Sawsan Youssef - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Phase 1 trial of MOv18, a first-in-class IgE antibody therapy for cancer

James Spicer - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

The relevance of endoglin and MMP14 to the metastatic potential of Ewing sarcoma cells

Pilar Puerto-Camacho - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Ewing's sarcoma

N/A

Functionally distinct T cell subsets contribute to ImmTAC-mediated anti-tumor response

Adel Benlahrech - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

N/A

Direct cancer cell/cancer-associated fibroblast interaction elicits resistance to oncolytic virus therapy in squamous cell carcinoma

Antonio Rullan - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Squamous cell carcinoma

Interferon

Associations of fecal microbial profiles with non-malignant breast disease and breast cancer in the Ghana Breast Health Study

Doratha Byrd - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Breast cancer

N/A

Design and optimization of a dendrimer-conjugated dual Bcl-2/Bcl-xL inhibitor, AZD0466, with improved therapeutic index

Marianne B. Ashford - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Thrombocytopenia

N/A

A lung TRACERx study

Chris Abbosh - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Exploiting the properties of VNAR domains for the development of novel efficacious protein drug conjugates targeting the oncofetal protein ROR1

Graham Cotton - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Triple-negative breast cancer

L-Tyrosine

Direct mutational consequences of CRISPR-cas9 gene-edited DNA repair genes

Xueqing Zou - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Mismatch repair deficiency

N/A

Investigating synergy between CHK1 and PARP inhibitors in BRCA2 mutant and restored cells

Hannah L. Smith - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

N/A

Rucaparib

Pulsatile MEK inhibition improves anti-tumor immunity and T cell function in Kras mutant lung cancer

Hyejin Choi - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Non Small Cell Lung cancer

selumetinib

Global tumor transcriptional activity reveals aggressiveness across multiple cancers

Shaolong Cao - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Prostate cancer

N/A

Optimizing the combination of the CDK4/6 inhibitor palbociclib and paclitaxel using cell cycle analysis

Jade A. Spencer - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

N/A

Palbociclib

The initial Precision Panc experience

David K. Chang - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Phase I study of the combination of a RAF-MEK inhibitor CH5126766 and FAK inhibitor defactinib in an intermittent dosing schedule with expansions in KRAS mutant cancers

Rajiv Shinde - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Non Small Cell Lung cancer

VS-6063

Mechanisms and therapeutic implications of hypermutation in gliomas

Mehdi Touat - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Mismatch repair deficiency

Temozolomide

The impact of image analysis and multiplex hybridization on PD-L1 diagnostic case triage

Matthew P. Humphries - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Non Small Cell Lung cancer

SP263

Investigating aneuploidy, CIN and mechanisms of DNA content reduction in cancer

Mara Mandelia - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Paclitaxel

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