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45280 Abstracts

A synthetic lethality approach to eradicate AML via synergistic activation of pro-apoptotic p53 by MDM2 and BET inhibitors

Sha Li - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute myelocytic leukemia

TP53

Results from the SPARTAN study

Clemente Aguilar - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Prostate cancer

N/A

A new TGF-b pathway reporter mouse for analysis of TGF-β signaling in normal homeostasis and cancer

Yu-an Yang - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Breast cancer

N/A

Persistence of smoking signature 4 in the non-small cell lung cancer genome

Pantelis A. Nicola - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Non Small Cell Lung cancer

N/A

A polygenic risk score-based genetic stratification for endometrial cancer

Cemsel Bafligil - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Endometrial Cancer

N/A

Integrated analysis of whole exome sequencing and hormone receptor expression data in endometrioid ovarian cancer

Robert L. Hollis - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Ovarian cancer

TP53

Clonal lineage and somatic hypermutation analysis of chronic lymphocytic leukemia by long-amplicon IGH chain sequencing

Jayde Chang - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Chronic Lymphocytic Leukemia

N/A

Elucidating genes that mediate brain colonization by metastatic melanoma cells

Denys Holovanchuk - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Leptomeningeal Metastasis

N/A

Sphingosine-1-phosphate receptor 1 signalling modulates macrophage recruitment to diffuse large B cell lymphomas and the phagocytosis of rituximab-opsonized tumor cells

Tracey Adams Perry - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Diffuse large B-cell lymphoma

Rituximab

A benefit-harm and cost-effectiveness analysis

Thomas Callender - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Prostate cancer

N/A

Recurrent transcriptionally active ESR1 fusions render therapeutic vulnerabilities to kinase inhibition in advanced breast cancer

Xuxu Gou - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Breast cancer

N/A

Estrogen receptor D538G mutation promotes cell migration via hyperactivation of Wnt signaling pathway

Zheqi Li - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

LGK974

STAT1-related antigen processing and presentation dictates prognosis in the fibroblast-rich subtype of stage II/III colon cancer

Amy M. McCorry - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Colorectal Cancer

N/A

A unique allogeneic cell therapy platform for the treatment of a broad range of malignancies

Istvan Kovacs - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Autoimmune (AI)

Lymphomas

Interferon Gamma

Selection of first-in-human clinical dose range for the tumor-targeted 4-1BB agonist MP0310 (AMG 506) using a pharmacokinetic/pharmacodynamics modeling approach

Alexander Link - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Colorectal Cancer

N/A

The role of IFITMs in maintaining glioma stem cells

Erisa Nita - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Brain cancer

IFN-lambda

Qualitatively distinct evolutionary games played by EGFR driven NSCLC

Nathan Farrokhian - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Non Small Cell Lung cancer

N/A

Stable RUNX1p.(Leu56Ser) kinetics during the course of myeloid neoplasms disagree with putative RUNX1 poor prognosis status

Lena Rai - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute myelocytic leukemia

N/A

Development of caninized monoclonal antibodies against PD1

Mikolaj Kocikowski - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Melanoma

N/A

MicroRNAs as biomarkers of resistance to HER2 inhibition in combination with chemotherapy in gastro-esophageal cancer

Hazel Lote - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Esophageal Cancer

Trastuzumab

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