App-Quantinova.ai

Next generation clonal neoantigen targeting T cells, generated using the PELEUSTM bioinformatics platform and the VELOSTM manufacturing method show superior reactivity and phenotypic characteristics than classical TIL products

Eleni Kotsiou - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Melanoma

N/A

Potent oral ERAP1 inhibitors modify the immunopeptidome in vivo and are novel immunotherapy agents

Jamie Ware - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Ankylosing spondylitis

Interferon Gamma

Targeting CD38 inhibits metabolic capacity of acute myeloid leukemia in the tumour microenvironment

Jayna J. Mistry - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute myelocytic leukemia

daratumumab Intravenous

Assays of conventional chemotherapeutics and targeted drugs for ovarian cancer using patient derived models

Concetta D'Ambrosio - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Ovarian cancer

Carboplatin

Cross-cancer cross-tissue transcriptome-wide association study (TWAS) of 11 cancers identifies 56 novel genes

Helian Feng - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Different pharmacodynamic profiles of ERK1/2 inhibition can elicit comparable anti-tumor activity

Christopher Hindley - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Reprogramming the tumor microenvironment

Xavier Jacq - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

IND-enabling characterization of ONC206 as the next bitopic antagonist for oncology

Varun Vijay Prabhu - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Advanced biliary tract carcinoma

Arrestin

Ligand blocking depletors versus receptor agonists

Linda Mrtensson - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Identification and validation of a novel immuno-oncology target and selection of a therapeutic antibody candidate with a pharmacologically beneficial activity profile

Arnima Bisht - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Colorectal Cancer

Interferon Gamma

Characterization of a panel of orthotopic syngeneic models using bioluminescent imaging for the evaluation of immuno oncology therapeutics

Diandong Jiang - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Cross-cancer GWAS meta-analysis of more than 370,000 cases and 530,000 controls identifies multiple novel cancer risk regions

Sara Lindstrm - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Type 2 diabetes mellitus

N/A

Targeting the tumor stroma using CAR T-cells

Sarah Ash - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Breast cancer

N/A

Accuracy improvements in somatic whole-genome small-variant calling with the DRAGEN platform

Konrad Scheffler - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

N/A

Developing a screen for O6-alkylguanines in human DNA using the damage-specific binding protein, Atl1

Hanum Yaakub - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

N/A

A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors

Juanita S. Lopez - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Atezolizumab

Integration of transcriptome and metabolome provides unique insights to pathways associated with obese breast cancer patients

Mohammed Abdullah Hassan - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Breast cancer

glutathione

Preclinical characterization of CB307, a half-life extended PSMAxCD137 bispecific Humabody therapeutic

James William Legg - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Prostate cancer

Human serum albumin

Bitter taste receptors system is expressed and functional in both HSCs and leukemic cells

Valentina Salvestrini - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute myelocytic leukemia

Procainamide

Androgen receptor (AR) and non-AR aberrations associated with outcomes in metastatic castration-sensitive prostate cancer (mCSPC) treated with apalutamide (APA) plus androgen deprivation therapy (ADT) in TITAN

Kim N. Chi - American Association for Cancer Research (AACR) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Prostate cancer

Androgen Tear

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