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28841 Abstracts

Long Term Safety and Efficacy of Adeno‐associated Viral Gene Therapy in a Canine Hemophilia A Model

P. Batty - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

Blood/haematological Diseases

Hemophilia

FVIII

rFVIIIFc for First‐time Immune Tolerance Induction (ITI) Therapy: Interim Results from the Global, Prospective verITI‐8 Study

L. Malec - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

FVIIIFc

Health Status of People Living with Non‐severe Hemophilia ‐ Insights from the Patient Reported Outcomes, Burdens and Experiences (PROBE) Study

C. Chai-Adisaksopha - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

Blood/haematological Diseases

Hemophilia

N/A

The Comparative Pharmacokinetic (PK) Profiles of Two Extended Half‐life (EHL) Factor VIII Concentrates [rFVIII‐Fc (Eloctate) and rAHF‐FL‐PEG (Adynovate)] in Adolescent Boys with Hemophilia A: Is there a Difference?

M. Carcao - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

Blood/haematological Diseases

Hemophilia

FVIII

Exploring Methods to Predict an Individual´s Pharmacokinetic Profile when Switching between Factor Concentrates in Hemophilia A

J. Yu - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

Blood/haematological Diseases

Hemophilia

NN7008

First Report of an Extended Half‐life FIX in Previously Untreated Patients with Haemophilia B

C. Barnes - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

Gastroenterology (GU)

Hemophilia

N/A

A Dysbiotic Gut Microbiota Diminishes Short‐Chain Fatty Acid Production and Increases Factor VIII Immunogenicity in Haemophilia A Mice

M.C. Cormier - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

Blood/haematological Diseases

Hemophilia

rFVIII

Increased in vivo Angiogenesis in von Willebrand Factor (VWF)‐deficient Mice

S. Selvam - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

Investigations of the von Willebrand Factor (VWF) p.Arg273Trp Variant Using Endothelial Colony Forming Cells (ECFCs)

M. Bowman - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

Gastroenterology (GU)

N/A

N/A

Large Gene Deletion in a VWD Patient Impairs VWF Storage in WPBs and Affects Phenotypic Features of Blood Outgrowth Endothelial Cells

H. Yadegari - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

Safety of Dabigatran Etexilate for Secondary Prevention of Venous Thromboembolism in Paediatric Patient

L. Brandao - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Venous thrombosis

Pradax

Efficacy and Safety of Dabigatran Etexilate for Treatment of Venous Thromboembolism in Paediatric Patients ‐ Results of the DIVERSITY Trial

M. Albisetti - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Venous thrombosis

Heparin

Platelet‐derived Microvesicles Reprogram Bone Marrow Megakaryocytes in the Setting of Inflammatory Disease

S. French - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

Novel Insights into Mouse Models of Ectopic Proplatelet Release

M. Spindler - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

O‐glycan Sialylation Regulates Thrombopoiesis through Interferon‐secreting Plasmacytoid Dendritic Cells

M. Lee-Sundlov - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

Interferon

High Thymic Stromal Lymphopoietin (TSLP) Expression Promotes Platelet Activation and Thrombosis in Kawasaki Disease via Promoting Mitophagy

X. Gu - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Kawasaki disease

Phosphatidylserine

Two Birds, One Stone: Anti‐β3 Integrin PSI Domain Antibodies Inhibit Both Platelet Aggregation and Blood Coagulation

T.W. Stratton - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

The Influence of Renal Impairment on Clinical Outcomes in Venous Thromboembolism Patients Enrolled in GARFIELD‐VTE

S. Goto - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Venous thrombosis

N/A

Negative D‐dimer Not Sufficient to Stop Anticoagulation in Men

J. Connors - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

N/A

N/A

N/A

Diagnosis of Pulmonary Embolism Using D‐Dimer Thresholds Selected According to Clinical Pre‐Test Probability

K. de Wit - Society of Thrombosis and Hemostasis Research (GTH/ISTH) , 2019

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Venous thrombosis

N/A

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