// App-Quantinova.ai

: Impact of Polymorphisms in Pharmacokinetic Genes on Tyrosine Kinase Inhibitor (TKI) Tolerability in Patients with Chronic Myeloid Leukemia (CML) or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL)

Researchers

Presenter

  • Jai N Patel

Principal Investigators

  • Lawrence J Druhan

  • Hang Zeng

  • Travis Beam

  • Donald C Moore

  • Ahmed Salem

  • Issam Hamadeh

  • Quanisha Savage

  • Aleksander L. Chojecki

  • Jing Ai

  • Thomas G. Knight

  • Brittany Knick Ragon

  • Nilay A. Shah

  • Srinivasa Reddy Sanikommu

  • Nury M Steuerwald

  • Mathew Smith

  • Alicia Hamilton

  • Keerthana Rangavajhula

  • Ariel Bell

  • Kendra Drummond

  • James T. Symanowski

  • Michael R. Grunwald

Medical Centers

  • Department of Cancer Biostatistics, Levine Cancer Institute, Atrium Health, Charlotte, NC

  • Molecular Biology Core Laboratory, Levine Cancer Institute, Atrium Health, Charlotte, NC

  • Atrium Health, Charlotte

  • Levine Cancer Institute, Atrium Health, Rock Hill, SC

  • Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte, NC

  • Department of Cancer Pharmacology and Pharmacogenomics, Levine Cancer Institute, Atrium Health, Charlotte, NC

  • Memorial Sloan Kettering Comprehensive Cancer Center, New York

  • Levine Cancer Institute, Atrium Health, Charlotte

  • Levine Cancer Institute, Atrium Health, Charlotte, NC

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Chronic Myelogenous Leukemia

  • Solid malignancies

Biomarkers

  • ATP Binding Cassette Transporter B1

  • ATP-binding cassette super-family G member 2

  • Breakpoint Cluster Region

  • Cytochrome P450 Family 3 Subfamily A Member 4

  • Cytochrome P450 Family 3 Subfamily A Member 5

Drug/Treatment

  • Bosutinib

  • Nilotinib

  • dasatinib

  • Imatinib

  • IkT001

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • Pharmacokinetics

  • Non Interventional

  • Tolerability

  • Prospective

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

Copyright © 2026. QuantiNova All rights reserved