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: Expression of Jak2 R1063H Leads to Altered Epor/Tpor Signaling, Changes in HSC Fitness and Represents Increased Risk of Thrombosis

Researchers

Presenter

  • Veronika Kropackova

Principal Investigators

  • Jan Gursky

  • Jana Balounova

  • Vladimir Korinek

  • Vladimir Divoky

  • Lucie Lanikova

Medical Centers

  • Department of Biology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic

  • Czech Centre for Phenogenomics & Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic

  • Department of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic

Locations

  • Czech Republic

Companies

  • N/A

Study Components

Therapeutic Area

  • Central Nervous System (CNS)

  • Pulmonary/Respiratory Diseases

  • Cardiovascular (CVS)

  • Oncology (ONC)

  • Genetic Disorder

  • Infectious Diseases (ID)

  • Congenital disorder

  • Blood/haematological Diseases

Disease

  • Myeloid neoplasms

  • Essential thrombocythemia

  • Congenital polycythemia

  • Venous thrombosis

  • Systemic inflammation

  • Anemia

  • Solid malignancies

  • Erythrocytosis, familial, 1

  • Spinocerebellar ataxia 1

Biomarkers

  • MPL proto-oncogene, thrombopoietin receptor

  • N-Acylethanolamine acid amidase

Drug/Treatment

  • Erythropoietin

Outcome

  • N/A

Study Design

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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