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: Targeting Hyperactivated Lck in PAX5 Rearranged Pediatric B-Cell Precursors Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Grazia Fazio

Principal Investigators

  • Manuel Quadri

  • Silvia Bresolin

  • Chiara Palmi

  • Michela Bardini

  • Athanasios Oikonomou

  • Jia-Wey Tu

  • Katerina Scharov

  • Alberto Peloso

  • Titus Watrin

  • Sanil Bhatia

  • Arndt Borkhardt

  • Andrea Biondi

  • Giovanni Cazzaniga

Medical Centers

  • SDB Department, Pediatric Hemato-Oncology, University of Padova, Padova, Italy

  • Tettamanti Research Center, Pediatrics, Department of Medicine, University of Milano-Bicocca, Monza, Italy

  • Medical Genetics, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy

  • Tettamanti Research Center, Pediatrics, University of Milano-Bicocca / Fondazione Tettamanti, Monza, Italy

  • Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany

  • Pediatric Haematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University and Hospital, Padova, Italy

  • Tettamanti Research Center, Dept. Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy

Locations

  • Italy

  • Germany

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Down syndrome

Biomarkers

  • Abelson murine leukemia viral oncogene homolog

  • ETV6-RUNX1

Drug/Treatment

  • Dexamethasone

  • Dekpak 13 Day Taperpak

  • staurosporine

  • Nintedanib

  • Bosutinib

  • Foretinib

  • dasatinib

Outcome

  • N/A

Study Design

  • Efficacy

  • Feasibility

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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