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: AMPK Downregulates Histone Gene Expression Via Dissociation of a Chromatin-Associated Transcription Complex in Response to Metabolic Stress in Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Guy Jacques Leclerc

Principal Investigators

  • Helena Gomes Dos Santos

  • Guangyan Sun

  • Ramin Shiekhattar

  • Julio C Barredo

Medical Centers

  • Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL

  • Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL

  • Pediatrics, University of Miami Miller School of Medicine, Miami, FL

  • Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Hematological malignancies

  • AICAR transformylase/IMP cyclohydrolase deficiency

  • T-cell acute lymphoblastic leukemia

Biomarkers

  • AMP-activated protein kinase

  • Histone-lysine N-methyltransferase 2A

  • ETV6-RUNX1

  • Tumor protein p53

Drug/Treatment

  • AICAR

  • TP53

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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