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: Epigenetic Fine Mapping and Functional Dissection of Inherited Non-Coding Variation Impacting the Pharmacogenomics of Acute Lymphoblastic Leukemia Treatment

Researchers

Presenter

  • Kashi Raj Bhattarai

Principal Investigators

  • Robert J. Mobley

  • Daniel C. Ferguson

  • Jonathan D. Diedrich

  • Brennan P. Bergeron

  • Wenjian Yang

  • Kristine R. Crews

  • Wendy Stock

  • Elisabeth Paietta

  • Steven M. Kornblau

  • Hiroto Inaba

  • Sima Jeha

  • Ching-Hon Pui

  • Cheng Cheng

  • Mary V. Relling

  • William E. Evans

  • Jun J.J. Yang

  • Daniel Savic

Medical Centers

  • Comprehensive Cancer Center, University of Chicago Medicine, Chicago, IL

  • Department of Oncology, St. Jude Children's Rsch./Hosp., Memphis, TN

  • ALBERT EINSTEIN COLLEGE OF MEDICINE, New York, NY

  • Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

  • Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN

  • Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN

  • Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN

  • Hematological Malignancies Program and Center for Precision Medicine in Leukemia, St. Jude Children's Research Hospital, Memphis, TN

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Mismatch repair deficiency

  • Solid malignancies

Biomarkers

  • Breakpoint Cluster Region

  • JunB proto-oncogene, AP-1 transcription factor subunit

Drug/Treatment

  • 6-mercaptopurine

  • Dexamethasone

  • Dekpak 13 Day Taperpak

  • Asparaginase

  • Prednisolone

  • thioguanine

  • Tabloid

  • Vincristine

Outcome

  • N/A

Study Design

  • Adaptive

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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