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TMIC-41 : ARGININE DEPRIVATION ALTERS DNA DAMAGE RESPONSE IN ARGINOSUCCINATE SYNTHETASE NEGATIVE GLIOBLASTOMA AND POTENTIATES STANDARD OF CARE

Researchers

Presenter

  • Avik Ghosh

Principal Investigators

  • Richard Perryman

  • Kevin O'Neill

  • Nelofer Syed

Medical Centers

  • Imperial College NHS Trust, London, United Kingdom

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Glioblastoma

Biomarkers

  • Ataxia Telangiectasia And Rad3-Related Protein

  • Breast cancer type 1 susceptibility protein

  • Argininosuccinate Synthase 1

  • Checkpoint kinase 1

  • checkpoint kinase 2

  • RAD51 Recombinase

  • Poly(ADP-Ribose) Polymerase 1

  • Proliferating cell nuclear antigen

Drug/Treatment

  • Temozolomide

  • ADI-PEG20

  • Arginine hydrochloride

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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