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EXTH-41 : COMBINED PHARMACOLOGICAL AND GENETIC SCREENING TO IDENTIFY DEPENDENCIES AND COMBINATIONS IN ACVR1-MUTANT DIFFUSE MIDLINE GLIOMA

Researchers

Presenter

  • Rebecca Rogers

Principal Investigators

  • Diana Carvalho

  • Yura Grabovska

  • Elisabet Fernandez

  • Elisa Izquierdo

  • Alan Mackay

  • Chris Jones

Medical Centers

  • ICL, london, United Kingdom

  • Institute of Cancer Research, London, United Kingdom

  • Salud Madrid, Madrid, Spain

Locations

  • United Kingdom

  • Spain

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Gliomas

  • Diffuse intrinsic pontine glioma

Biomarkers

  • Mitogen-activated protein kinase

  • Phosphatidylinositol 3-kinase regulatory subunit alpha

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Cyclin B1

  • Cyclin dependent kinase 1

  • WEE1 G2 Checkpoint Kinase

  • Transforming Growth Factor Beta 1

  • Serine/threonine-protein kinase mTOR

Drug/Treatment

  • Everolimus

  • Trametinib

  • Vandetanib

  • AZD-8055

  • AZD-1775

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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