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CTNI-67 : DUAL INHIBITION OF POST-RADIOGENIC ANGIO-VASCULOGENESIS BY OLAPTESED PEGOL (NOX-A12) AND BEVACIZUMAB IN GLIOBLASTOMA – INTERIM DATA FROM THE FIRST EXPANSION ARM OF THE GERMAN PHASE 1/2 GLORIA TRIAL

Researchers

Presenter

  • Frank Giordano

Principal Investigators

  • Sonia Leonardelli

  • Lea Friker

  • Christina Schaub

  • Roberta Turiello

  • Elena Sperk

  • Iris Mildenberger

  • Franziska Grau

  • Daniel Paech

  • Torsten Pietsch

  • Wolf Mueller

  • Oliver Grauer

  • Mirjam Renovanz

  • Ghazaleh Tabatabai

  • Sied Kebir

  • Martin Glas

  • Sotirios Bisdas

  • Peter Hambsch

  • Clemens Seidel

  • Michael Holzel

  • Ulrich Herrlinger

Medical Centers

  • Department of Neuroradiology at the National Hospital for Neurology, London, London, United Kingdom

  • Department of Radiotherapy, University Hospital Leipzig, Leipzig, Germany

  • Institute of Experimental Oncology, University Hospital Bonn, Bonn, Germany

  • 1Department of Neurology, University Hospital Münster Münster Germany

  • Division of Neurooncology, Department of Neurology, University Hospital Bonn, Bonn, Germany

  • Institute of Neuropathology, University Hospital Leipzig, Leipzig, Germany

  • Department of Radiation Oncology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

  • Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

  • Department of Neurology & Interdisciplinary Neuro-Oncology, University Hospital Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany

  • Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany

  • Department of Radiation Oncology, University Hospital Bonn, Bonn, Germany

Locations

  • United Kingdom

  • Germany

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Glioblastoma

Biomarkers

  • O-6-methylguanine DNA methyltransferase

Drug/Treatment

  • NOX A12

  • Bevacizumab

Outcome

  • N/A

Study Design

  • N/A

Phase

  • I/II

Study Id's

  • NCT04121455

Sponsors

  • N/A

Result

  • N/A

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