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CTNI-30 : LOGGIC/FIREFLY-2: A PHASE 3, RANDOMIZED TRIAL OF TOVORAFENIB VS. CHEMOTHERAPY IN PEDIATRIC PATIENTS WITH NEWLY DIAGNOSED LOW-GRADE GLIOMA HARBORING AN ACTIVATING RAF ALTERATION

Researchers

Presenter

  • Cornelis van Tilburg

Principal Investigators

  • David T Jones

  • Rene Schmidt

  • Shivaram Avula

  • Antoinette Schouten- van Meeteren

  • Astrid Sehested

  • Enrico Opocher

  • Pablo Hernaiz Driever

  • Ruth Witt

  • David Ziegler

  • Samuel Blackman

  • Xin Zhao

  • Li-Pen Tsao

  • Michael Cox

  • Darren Hargrave

  • Olaf Witt

Medical Centers

  • Hopp Childrens Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Research Center (DKFZ), Heidelberg, Germany

  • Department of Radiology, Alder Hey Children's Hospital NHS Foundation Trust, Liverpool, United Kingdom

  • Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany

  • Day One Biopharmaceuticals, South San Francisco, CA, USA

  • Kids Cancer Centre, Sydney Children's Hospital, Sydney, Australia

  • Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany

  • UCL Great Ormond Street Institute of Child Health, London, United Kingdom

  • Princess Máxima Center for Pediatric Oncology, Department of Neuro-oncology, Utrecht, Netherlands

  • Pediatric Hematology, Oncology and Stem Cell Transplant Division, Padua University Hospital, Padua, Italy

  • Institute of Biostatistics and Clinical Research, Munster, Germany

  • Department of Pediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark

Locations

  • Germany

  • United Kingdom

  • Netherlands

  • Italy

  • United States

  • Australia

  • Denmark

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Low-grade gliomas

Biomarkers

  • N/A

Drug/Treatment

  • Vinblastine

Outcome

  • N/A

Study Design

  • Randomized

  • Multicenteric

Phase

  • III

Study Id's

  • NCT04775485

Sponsors

  • N/A

Result

  • N/A

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