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1121 : Intricate Roles of Low Gene Copy Numbers for Complement C4, C4A Deficiency and HLA-DRB1*03 as Genetic Risk Factors for Myositis, Its Subgroups and Autoantibodies

Researchers

Presenter

  • Danlei Zhou

Principal Investigators

  • Simon Rothwell

  • Olga Kryštůfková

  • Antonella Notarnicola

  • Samantha Coss

  • Rabheh Abdul Aziz

  • Katherine E Miller

  • Amanda Dang

  • G. Richard Yu

  • Joanne Drew

  • Emeli Lundstrom

  • Lauren Pachman

  • Gulnara Mamyrova

  • Rodolfo V Curiel

  • Boel De Paepe

  • Jan De Bleecker

  • Antony Payton

  • William Ollier

  • Terrance P O'Hanlon

  • Ira Targoff

  • Willy Flegel

  • Vidya Sivaraman

  • Edward Oberle

  • Shoghik Akoghlanian

  • Kyla Driest

  • Charles H Spencer

  • Yee Ling Wu

  • Haikady N Nagaraja

  • Stacy P Ardoin

  • Hector Chinoy

  • Lisa G Rider

  • Frederick Miller

  • Ingrid Lundberg

  • Leonid Padyukov

  • Jiří Vencovský

  • Janine A Lamb

  • Chack-Yung Yu

Medical Centers

  • Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH

  • National Institute of Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

  • Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Czech Republic

  • Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

  • Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH

  • Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH

  • Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL

  • Department of Medicine, the George Washington University School of Medicine and Health Sciences, Washington, DC

  • Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

  • Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, United Kingdom

  • Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD

  • Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH

  • Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL

  • Center for Biostatistics, The Ohio State University, Columbus, OH

  • The University of Manchester, Salford, United Kingdom

  • Rheumatology Unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden

  • Karolinska Institutet, Stockholm, Sweden

Locations

  • United States

  • United Kingdom

  • Czech Republic

  • Sweden

  • Belgium

Companies

  • N/A

Study Components

Therapeutic Area

  • Autoimmune (AI)

  • Genetic Disorder

  • Musculoskeletal

Disease

  • Complement component 4A deficiency

  • Myositis

Biomarkers

  • Major histocompatibility complex, class II, DR beta 1

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • N/A

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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