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: Biological Brain Age Prediction Using Machine Learning on Structural Neuroimaging Data: Multi-Cohort Validation Against Biomarkers of Alzheimer’s Disease and Neurodegeneration

Researchers

Presenter

  • Irene Cumplido-Mayoral

Principal Investigators

  • Grégory Operto

  • Carles Falcon

  • Mahnaz Shekari

  • Raffaele Cacciaglia

  • Marta Milà-Alomà

  • Luigi Lorenzini

  • Silvia Ingala

  • Alle Meije Wink

  • Henk-Jan Mutsaerts

  • Carolina Minguillón

  • Karine Fauria

  • Jose Luis Molinuevo

  • Sven Haller

  • Gael Chetelat

  • Adam Waldman

  • Adam J. Schwarz

  • Frederik Barkhof

  • Gwendlyn Kollmorgen

  • Ivonne Suridjan

  • Norbert Wild

  • Henrik Zetterberg

  • Kaj Blennow

  • Marc Suárez-Calvet

  • Verónica Vilaplana

  • Juan Domingo Gispert

Medical Centers

  • Hospital del Mar Medical Research Insitute (IMIM)

  • Universitat Pompeu Fabra,

  • Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London

  • UK Dementia Research Institute

  • Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC

  • Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", Institut Blood and Brain Caen-Normandie

  • Takeda Pharmaceutical Company Ltd

  • Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden

  • Roche Diagnostics International AG

  • Department of Signal Theory and Communications, Universitat Politècnica de Catalunya

  • Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES)

  • Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)

  • Institutes of Neurology & Healthcare Engineering, University College London

  • Servei de Neurologia, Hospital del Mar

  • Laboratory of Neuroimaging (LONI), University of Southern California

  • CIRD Centre d'Imagerie Rive Droite

  • Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation

  • Lundbeck A/S

  • Hong Kong Center for Neurodegenerative Diseases

  • Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation

  • This project has received support from European Prevention of Alzheimer’s Dementia (EPAD) grant no. 115736

  • Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Sweden

  • Hospital del Mar Medical Research Insitute (IMIM)

  • Centre for Dementia Prevention, Edinburgh Imaging, and UK Dementia Research Institute at The University of Edinburgh

Locations

  • United Kingdom

  • United States

  • India

  • Hong Kong

  • Venezuela

Companies

  • N/A

Study Components

Therapeutic Area

  • Central Nervous System (CNS)

Disease

  • White matter hyperintensities

  • Alzheimer's disease

Biomarkers

  • Apolipoprotein E

  • Amyloid beta 42

  • Cerebrospinal fluid

  • Neurofilament-light chain

Drug/Treatment

  • Mofezolac

Outcome

  • N/A

Study Design

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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