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: Complement and NfL associations with brain structure and functional connectivity alterations in presymptomatic and symptomatic GRN mutation carriers

Researchers

Presenter

  • Taru M. Flagan

Principal Investigators

  • Suvi Häkkinen

  • David McFall

  • Carolin Heller

  • Jonathan D Rohrer

  • Jesse A. Brown

  • Alex Jihun Lee

  • Lorenzo Pasquini

  • Maria Luisa Mandelli

  • Marilu Gorno-Tempini

  • Brian Appleby

  • Brad C. Dickerson

  • Kimiko Domoto-Reilly

  • Tatiana M. Foroud

  • Daniel H. Geschwind

  • Nupur Ghoshal

  • Neill R. Graff-Radford

  • Murray Grossman

  • Ging-Yuek Robin Hsiung

  • Eric J. Huang

  • Edward D. Huey

  • Kejal Kantarci

  • Anna M. Karydas

  • Daniel Kaufer

  • David S. Knopman

  • Irene Litvan

  • Ian R Mackenzie

  • Mario F. Mendez

  • Chiadi U Onyike

  • Leonard Petrucelli

  • Eliana Marisa Ramos

  • Erik D. Roberson

  • Julio C. Rojas

  • Maria Carmela Tartaglia

  • Arthur W. Toga

  • Sandra Weintraub

  • Leah K. Forsberg

  • Hilary W. Heuer

  • Bradley F. Boeve

  • Adam L. Boxer

  • Howard J. Rosen

  • Bruce L. Miller

  • Fermin Moreno

  • William W. Seeley

  • Suzee E. Lee

Medical Centers

  • University of Alabama, Birmingham, AL

  • Massachusetts General Hospital, Boston, MA

  • University of Southern California, CA

  • David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA

  • University CollegeLondon, UK

  • Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada

  • National Cell Repository for Alzheimer's Disease (NCRAD)

  • Case Western Reserve University,

  • University of British Columbia,

  • University of Southern California, Los Angeles, CA

  • Washington University School of Medicine, St. Louis, MO

  • University of Washington, WA

  • Mayo Clinc

  • University of California, San Francisco, CA

  • The Johns Hopkins University School of Medicine, MD.

  • University of California, San Diego, La Jolla, CA

  • Univeristy of North Carolina, NC

  • Penn Memory Center, University of Pennsylvania

  • Dementia Research Centre at UCL Queen Square Institute of Neurology

  • Northwestern University, Illinois

  • Columbia University, NY

  • Hospital Universitario Donostia,

Locations

  • United States

  • United Kingdom

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Central Nervous System (CNS)

Disease

  • Frontotemporal dementia

Biomarkers

  • Complement 3

  • Granulin precursor

  • Cerebrospinal fluid

  • Neurofilament-light chain

Drug/Treatment

  • Progranulin

Outcome

  • N/A

Study Design

  • Cross-Sectional

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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