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FRI0406 (2018) : Increased frequency of circulating cd163+ non-classical monocytes in scleroderma and enhanced dual polarisation towards m1 and m2-like phenotypes in monocyte-derived macrophages

Researchers

Presenter

  • A. Tam

Principal Investigators

  • L. Reinke-Breen

  • G. Trujillo

  • S. Xu

  • C. P. Denton

  • D. J. Abraham†

  • G. Jarai†

  • V. H. Ong†

Medical Centers

  • Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom

  • Discovery Biology, Fibrotic Diseases, Bristol-Myers Squibb, Pennington, United States

Locations

  • United Kingdom

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Autoimmune (AI)

Disease

  • Scleroderma

Biomarkers

  • Peripheral blood mononuclear cell

  • Cluster of Differentiation 14

  • Cluster of Differentiation 163

  • Cluster of Differentiation 206

  • Cytokine

  • Fc gamma RIIIa

  • Interleukin 4

  • Interferon-gamma

Drug/Treatment

  • Interferon Gamma

  • IL-4

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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