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S301 : RAVULIZUMAB REDUCES THE RISK OF THROMBOSIS IN ADULT PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA AND HIGH DISEASE ACTIVITY: 2-YEAR DATA FROM A PHASE 3, OPEN-LABEL STUDY

Researchers

Presenter

  • Rgis Peffault de Latour

Principal Investigators

  • Anita Hill

  • Wolfgang Freder

  • Caroline Piatek

  • Morag Griffin

  • Masayo Ogawa

  • Jimmy Wang

  • Kensuke Usuki

  • Alexander Rth

  • Jong Wook Lee

Medical Centers

  • Dept. of Medicine I, Div. of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria

  • Haematology Department,St James's University Hospital,Leeds,United Kingdom

  • Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan

  • Jane Anne Nohl Division of Hematology, Keck School Of Medicine of USC, Los Angeles, CA

  • Hospital Saint Antoine, Paris, France

  • Department of Hematology and Stem Cell Transplantation,University of Duisburg-Essen,Essen,Germany

  • Department of Hematology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea,Seoul,Korea, Democratic People's Republic Of

  • Alexion Pharmaceuticals, Inc., Boston, United States

  • Alexion Pharmaceuticals, Inc.,Leeds,United Kingdom

Locations

  • Austria

  • United Kingdom

  • Japan

  • United States

  • France

  • Germany

  • Republic of South Korea

Companies

  • N/A

Study Components

Therapeutic Area

  • Pulmonary/Respiratory Diseases

  • Genetic Disorder

  • Central Nervous System (CNS)

  • Angiology

  • Cardiovascular (CVS)

  • Blood/haematological Diseases

Disease

  • Paroxysmal nocturnal hemoglobinuria

  • Peripheral artery disease

  • Transient Ischemic Attack

  • Transient ischemic attack

  • Ischemic stroke

  • Myocardial infarction

  • Deep vein thrombosis

  • Angina

  • Venous thrombosis

Biomarkers

  • Lactate dehydrogenase

Drug/Treatment

  • Eculizumab

Outcome

  • N/A

Study Design

  • Randomized

  • Open Label

  • Multicenteric

Phase

  • III

Study Id's

  • NCT02946463

Sponsors

  • N/A

Result

  • N/A

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