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S143 : CLINICAL IMPACT OF RECURRENT GENE MUTATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA: A RETROSPECTIVE, MULTI-CENTER COHORT STUDY BY ERIC, THE EUROPEAN RESEARCH INITIATIVE ON CLL, IN HARMONY

Researchers

Presenter

  • Larry Mansouri

Principal Investigators

  • Lesley-Ann Sutton

  • Manja Meggendorfer

  • Helen Parker

  • Ferran Nadeu

  • Christian Brieghel

  • Stamatia Laidou

  • Riccardo Moia

  • Davide Rossi

  • Mark Catherwood

  • Jana Kotaskova

  • Julio Delgado

  • Ana E Rodrguez-Vicente

  • Roco Benito

  • Gian Matteo Rigolin

  • Silvia Bonfiglio

  • Lydia Scarfo

  • Mattias Mattsson

  • Zadie Davis

  • Ajay Gogia

  • Lata Rani

  • Panagiotis Baliakas

  • Cecilia Jylh

  • Aron Skaftason

  • Inmaculada Rapado

  • Fatima Miras

  • Joaqun Martinez-Lopez

  • Javier de la Serna

  • Jess Mara Hernndez Rivas

  • Patrick Thornton

  • Mara Jos Calasanz

  • Zoltn Mtrai

  • Csaba Bdr

  • Karin E. Smedby

  • Blanca Espinet

  • Anna Puiggros

  • Ritu Gupta

  • Lars Bullinger

  • Francesc Bosch

  • Brbara Tazn-Vega

  • Fanny Baran-Marszak

  • David Oscier

  • Florence Nguyen-Khac

  • Thorsten Zenz

  • Maria Jose Terol

  • Paolo Ghia

  • Antonio Cuneo

  • Mara Hernndez-Snchez

  • Sarka Pospisilova

  • Ken Mills

  • Gianluca Gaidano

  • Carsten U. Niemann

  • Elias Campo

  • Jonathan C Strefford

  • Kostas Stamatopoulos

  • Richard Rosenquist

Medical Centers

  • Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

  • Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom

  • Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden

  • Service d’hématologie biologique Hôpital Avicenne Assistance Publique des Hôpitaux de Paris Bobigny,Paris,France

  • Molecular Cytogenetics Laboratory, Pathology Department,Hospital del Mar,Barcelona,Spain

  • Department of Pathology, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

  • Department of Hematology,INCLIVA Research Insitute, University of Valencia,Valencia,Spain

  • Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy, Novara, Italy

  • Hematological Diseases Laboratory,CIMALAB Diagnostics, University of Navarra,Pamplona,Spain

  • Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom

  • Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

  • Department of Oncology 5073 Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark

  • Department Hematology, Oncology and Tumor Immunology, Charite University Hospital, Berlin, Germany

  • Department of Pneumology, Hospital Universitario de Bellvitge, Barcelona, Spain

  • Sorbonne Université,Paris,France;Service d'Hématologie Clinique,Groupe Hospitalier Pitié-Salpêtrière,Paris,France

  • Department of Medical Sciences, University of Ferrara, Ferrara, Italy

  • Dept of Molecular Pathology,Royal Bournemouth Hospital,Bournemouth,United Kingdom

  • All India Institute of Medical Sciences, New Delhi, India

  • Hospital Universitario Quiron Madrid, Madrid, Spain

  • Hospital Universitario 12 de Octubre, Madrid, Spain, Madrid, Madrid, Spain

  • Munich Leukemia Laboratory, Munich, Germany.

  • Medical Oncology and Hematology, University and University Hospital Zurich, Zurich, Switzerland

  • Department of Immunology, Genetics and Pathology, Uppsala, Sweden

  • Department of Internal Medicine, Hematology, Oncol

  • Academic Unit of Cancer Sciences Faculty of Medicine, University of Southampton,Southampton, United Kingdom

  • Centre for Research and Technology Hellas, Institute of Applied Biosciences,Thessaloniki,Greece

  • Rheumatology Department, Beaumont Hospital, Dublin, Ireland

  • Cancer Research Center (IBMCC-CSIC). University of Salamanca., Salamanca, Spain

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Department of Pathology, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

  • Cancer Research Center (IBMCC-CSIC). University of Salamanca., Salamanca, Spain

  • Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

  • MTA-SE Momentum Molecular Oncohematology Research Group, First Department of Pathology and Experimental Cancer Research,Semmelweis University,Budapest,Hungary

Locations

  • Spain

  • United Kingdom

  • Sweden

  • France

  • Czech Republic

  • Italy

  • Denmark

  • Germany

  • India

  • Switzerland

  • Greece

  • Ireland

  • Hungary

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Chronic Lymphocytic Leukemia

Biomarkers

  • Neurogenic locus notch homolog protein 1

  • Baculoviral IAP repeat-containing protein3

  • Exportin 1

  • Tumor protein p53

  • Splicing Factor 3b Subunit 1

Drug/Treatment

  • TP53

Outcome

  • N/A

Study Design

  • Multicenteric

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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