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PB1480 : TWO CURRENTLY RECRUITING PHASE III TRIALS: COMMODORE 1 AND 2 EVALUATING CROVALIMAB VS ECULIZUMAB IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA WITH OR WITHOUT CURRENT ANTI–COMPLEMENT THERAPY

Researchers

Presenter

  • Austin Kulasekararaj

Principal Investigators

  • Antonio Risitano

  • Alexander Rth

  • Guangsheng He

  • Jeffrey Pu

  • Lilyan Wright

  • Anita Appius

  • Alexandre Sostelly

  • Sasha Sreckovic

  • Sven Franz Stanzel

  • Talha Munir

  • Jun-ichi Nishimura

Medical Centers

  • The University of Arizona Cancer Center,Tuscon,United States

  • Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

  • Department of Hematology and Stem Cell Transplantation,University Hospital Essen, University of Duisburg-Essen,Essen,Germany

  • Hematology and BMT Unit,AORN Moscati Avellino,Avellino,Italy

  • Department of Pathologic Oncology, Mie University Graduate School of Medicine, Mie, Japan

  • Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China

  • Hollings Cancer Center, Medical University of South Carolina, Charleston, SC

  • F. Hoffmann-La Roche Ltd., Basel, Switzerland

  • Department of Haematological Medicine,King’s College Hospital‐NHS Foundation Trust, NIHR Wellcome Foundation Clinical Research Facility, King’s College London,London,United Kingdom

  • Genentech Inc., San Francisco, United States

Locations

  • United States

  • Italy

  • Germany

  • Japan

  • China

  • United Kingdom

  • Switzerland

Companies

  • N/A

Study Components

Therapeutic Area

  • Blood/haematological Diseases

Disease

  • Paroxysmal nocturnal hemoglobinuria

Biomarkers

  • N/A

Drug/Treatment

  • Eculizumab

Outcome

  • N/A

Study Design

  • Randomized

  • Pharmacokinetics

  • Non Inferiority

Phase

  • III

Study Id's

  • NCT03157635

  • NCT04432584

  • NCT04434092

Sponsors

  • N/A

Result

  • N/A

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