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EP689 : INHIBITION OF COMPLEMENT C1S WITH SUTIMLIMAB IN PATIENTS WITH COLD AGGLUTININ DISEASE (CAD): 1-YEAR INTERIM RESULTS OF THE PHASE 3 CARDINAL STUDY LONG-TERM FOLLOW-UP

Researchers

Presenter

  • Alexander Rth

Principal Investigators

  • Wilma Barcellini

  • Shirley D'Sa

  • Yoshitaka Miyakawa

  • Catherine M. Broome

  • Marc Michel

  • David J. Kuter

  • Bernd Jilma

  • Tor Henrik Anderson Tvedt

  • Ilene Weitz

  • Parija Patel

  • Xiayou Jiang

  • Caroline Reuter

  • Jun Su

  • Frank Shafer

  • Michelle Lee

  • William Hobbs

  • Sigbjrn Berentsen

Medical Centers

  • Division of Hematology, MedStar Georgetown University Hospital,Washington DC,Vereinigte Staaten

  • UCLH Centre for Waldenström's Macroglobulinemia and Related Conditions, University College London Hospitals NHS Foundation Trust,London,Vereinigtes Königreich

  • Sanofi, employee at time of study,Cambridge, MA,United States

  • Thrombosis and Hemostasis Center,Saitama Medical University Hospital,Saitama,Japan

  • Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany

  • Henri Mondor University Hospital, Assistance Publique-Hopitaux de Paris (AP-HP), Creteil, France

  • Department of Clinical Pharmacology, Medical University of Vienna, Austria

  • USC Keck School of Medicine, Los Angeles, United States

  • Department of Research and Innovation, Haugesund Hospital, Haugesund, Norway

  • Division of Cardiology, The Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States,

  • Sanofi, Cambridge, MA, United States,Cambridge, MA,United States

  • Section for Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway

  • IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milano, Italy

Locations

  • United States

  • United Kingdom

  • Japan

  • Germany

  • France

  • Austria

  • Norway

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Pulmonary/Respiratory Diseases

Disease

  • Chronic obstructive pulmonary disease

Biomarkers

  • Complement Component 1, S Subcomponent

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • Open Label

  • Single Arm

Phase

  • III

Study Id's

  • NCT03347396

Sponsors

  • N/A

Result

  • N/A

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