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P360 : EFFICACY AND SAFETY OF DARATUMUMAB IN PEDIATRIC AND YOUNG ADULT PATIENTS WITH RELAPSED/REFRACTORY T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA OR LYMPHOBLASTIC LYMPHOMA: RESULTS FROM PHASE 2 DELPHINUS STUDY

Researchers

Presenter

  • Ajay Vora

Principal Investigators

  • David Teachey

  • Francisco Bautista

  • John Moppett

  • Pablo Velasco Puy

  • Concetta Micalizzi

  • Claudia Rossig

  • Neerav Shukla

  • Gil Gilad

  • Franco Locatelli

  • Andr Baruchel

  • C. Michel Zwaan

  • Elizabeth A. Raetz

  • Nibedita Bandyopadhyay

  • Lorena Lopez Solano

  • Robyn M. Dennis

  • Robin Carson

  • Laura E. Hogan

Medical Centers

  • Department Medicine,Memorial Sloan-Kettering Cancer Center,New York,Vereinigte Staaten

  • New York University Medical Center, New York City, NY

  • Princess Máxima Center for Pediatric Oncology,Utrecht,Países Bajos

  • Clinical Experimental Haematology Unit,IRCCS Istituto Gianni

  • Pediatric Hematology and Immunology Department, Robert Debré University Hospital (APHP and Paris Diderot University), Paris, France

  • Division of Oncology,Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA,Vereinigte Staaten

  • Development, LLC,Spring House,United States

  • New York University Medical Center, New York City, NY

  • Development,Raritan,Stati Uniti

  • Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petah-Tikva, Israel

  • Clinical Experimental Haematology Unit,IRCCS Istituto Giannina Gaslini,Genova,Italien

  • Department of Pediatrics,Children's Hospital of New Jersey at Newark Beth Israel Medical Center,Newark, NJ,Stati Uniti

  • Paediatric infection & Immunology, Bristol Royal Hospital for Children, Bristol,United Kingdom

  • Development, LLC,Raritan, NJ,États-unis

  • Departme

  • Division of Oncology,Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA,Vereinigte Staaten

  • Development,Raritan,United States

  • Servicio de Oncología y Hematología Pediátricas, Vall d'Hebron Hospital,Barcelona,Espagne

  • Princess Máxima Center for Pediatric Oncology,Utrecht,Países Bajos

  • New York University Medical Center, New York City, NY

  • Department of Haematology, Great Ormond Street Hospital For Children, London, United Kingdom

  • New York University Medical Center, New York City, NY

  • Department of Haematology,Great Ormond Street Hospital for Children,London,Royaume-uni

  • Development, LLC,Spring House, PA,Estados Unidos

  • Pediatric Hematology

  • Janssen Research &amp

  • Department of Haematology, Great Ormond Street Hospital For Children, London, United Kingdom

  • Clinical Experimental Haematology Unit,IRCCS Istituto Giannina Gaslini,Genova,Italien

  • Janssen Research &amp

  • Department of Neurology,Memorial Sloan-Kettering Cancer Center,New York,États-unis

  • Division of Oncology,Center for

  • University Children's Hospital Münster,Münster,Alemania

  • Paediatric Haematology,Royal Hospital for Children ,Glasgow,Reino Unido

  • Development,Raritan, NJ,Vereinigte Staaten

  • Development,Raritan,Estados Unidos

  • Development, LLC,Rarit

  • Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petah-Tikva, Israel

  • Princess Máxima Center for Pediatric Oncology,Utrecht,Países Bajos

  • Paediatric Haematology,Royal Hospital for Children ,Glasgow,Reino Unido

  • University Childrens Hospital Munster, Muenster, Germany.

  • University Childrens Hospital Munster, Muenster, Germany.

  • Servicio de Oncología y Hematología Pediátricas, Vall d'Hebron Hospital,Barcelona,Espagne

  • Princess

  • Development,Spring House, PA,Stati Uniti

  • Paediatric Haematology,Bristol Royal Hospital for Children,Bristol,Rei

  • Development,Spring House,États-unis

  • Pediatric Hematology and Immunology Department, Robert Debré University Hospital (APHP and Paris Diderot University), Paris, France

  • New York University Langone Medical Center,New York, NY,Vereinigte Staaten

  • Epidemiology and Biostatisticis, Memorial Sloan-Kettering Cancer Center, New York, New York, United States

  • Department of Pediatrics,Memorial Sl

  • Department of Neurology,Memorial Sloan-Kettering Cancer Center,New York,États-unis

  • Department of Pediatrics,Children's H

  • Princess Maxima Center for Pediatric Oncology, Netherlands

  • Department of Pediatric Hematology-Oncology,Schneider Children's Medi

  • Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petah-Tikva, Israel

  • Development, LLC,Spring House, PA,Vereinigte Staaten

  • Servicio de Oncología y Hematología Pediátricas, Vall d'Hebron Hospital,Barcelona,Espagne

  • Servicio de Oncología y Hematología Pediátr

  • Univer

  • Servicio de Oncología y Hematología Pediátricas, Vall d'Hebron Hospital,Barcelona,Espagne

  • Princess Maxima Center for Pediatric Oncology, Netherlands

  • Department of Haematology,Great Ormond

  • Clinical Experimental Haematology Unit,IRCCS Istituto Giannina Gaslini,Genova,Italien

  • Princess Máxima Center for Pediatric Oncology,Utrecht,Países Bajos

  • Pediatric Hematology, Robert Debre Hospital - APHP and University Paris Diderot, Paris, France

  • Clinical Experimental Haematology Unit,IRCCS Istituto Giannina Gaslini,Genova,Italien

  • New York University Medical Center, New York City, NY

  • University Children's Hospital Münster,Münster,Alemania

  • Paediatric Haematology,Royal Hospital for Children ,Glasgow,Vereinigtes Königreich

  • Department of Pediatrics,Children's Hospital of New Jersey at Newark Beth Israel Medical Center,Newark, NJ,Stati Uniti

  • Department of Pediatrics,Children's Hospital of New Jersey at Newark Beth Israel Medical Center,Newark, NJ,Stati Uniti

  • Department of Haematology, Great Ormond Street Hospital For Children, London, United Kingdom

Locations

  • United Kingdom

  • United States

  • Netherlands

  • Venezuela

  • Spain

  • Italy

  • Germany

  • Israel

  • France

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Oncology (ONC)

Disease

  • T-cell acute lymphoblastic leukemia

  • Lymphomas

Biomarkers

  • Breakpoint Cluster Region

Drug/Treatment

  • Cyclophosphamide

  • Cyclophosphamide Injection

  • 6-mercaptopurine

  • Allmercap

  • Methotrexate

  • daratumumab Intravenous

  • Cytarabine liposomal

  • Sparsentan

Outcome

  • N/A

Study Design

  • N/A

Phase

  • II

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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