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P666 : ACALABRUTINIB ± OBINUTUZUMAB VS OBINUTUZUMAB + CHLORAMBUCIL IN TREATMENT-NAIVE CHRONIC LYMPHOCYTIC LEUKEMIA: 5-YEAR FOLLOW-UP OF ELEVATE-TN

Researchers

Presenter

  • Jeff P. Sharman

Principal Investigators

  • Wojciech Jurczak

  • Alan Skarbnik

  • Krish Patel

  • Ian W. Flinn

  • Manali Kamdar

  • Talha Munir

  • Renata Walewska

  • Laura Maria Fogliatto

  • Yair Herishanu

  • Versha Banerji

  • George Follows

  • Patricia Walker

  • Karin Karlsson

  • Paolo Ghia

  • Ann Janssens

  • Florence Cymbalista

  • Emmanuelle Ferrant

  • William G. Wierda

  • Veerendra Munugalavadla

  • Ting Yu

  • Min Hui Wang

  • Jennifer A. Woyach

Medical Centers

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Novant Health Cancer Institute,Charlotte, NC,Estados Unidos

  • Tel Aviv Sourasky Medical Center,Tel Aviv,Израиль

  • Tel Av

  • University Hospitals Leuven and KU Leuven, Leuven, Belgium

  • AstraZeneca, South San Francisco,California,Estados Unidos

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Department of Leukemia,Division of Cancer Medicine, MD Anderson Cancer Center,H

  • Cancer Care, University Hospitals Dorset,Bournemouth,United Kingdom

  • Haematology, Haematological Malignancy Diagnostic Service (HMDS), St. James's Institute of Oncology, Leeds, UK

  • Departments of Internal Medicine, Biochemistry &amp

  • University of Colorado, CO.

  • Novant Health Cancer Institute,Charlotte,

  • Cancer Care, University Hospitals Dorset,Bournemouth,United Kingdom

  • Hospital De Clinicas de Porto Alegre, Porto Alegre RS, Brazil

  • Somogy County Mór Kaposi General Hospital, Kaposvár, Hungary

  • Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d'Hématologie C

  • University of Colorado Cancer Center,Aurora, CO,Estados Unidos

  • AstraZeneca,South San Francisco, CA,United St

  • Haematology, Haematological Malignancy Diagnostic Service (HMDS), St. James's Institute of Oncology, Leeds, UK

  • Bobigny: Hématologie biologique, Hopital Avicenne, Université Sorbonne Paris Nord,Bobigny,Francia

  • Novant Health Cancer Institute,Charlotte, NC,Estados Unidos

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Sarah Cannon Research Institute/Tennessee Oncology, Nashville, Tennessee, USA

  • Bobigny: Hématologie biologique, Hopital Avicenne, Université Sorbonne Paris Nord,Bobigny,Francia

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Department of Radiology, Addenbrooke's Hospital, Cambridge, United Kingdom

  • University Hospitals Leuven and KU Leuven, Leuven, Belgium

  • Cancer Care, University Hospitals Dorset,Bournemouth,United Kingdom

  • Willamette Valley Cancer Institute and Research Center,Eugene, OR,Verenigde Staten

  • Cancer Care, University Hospitals Dorset,Bournemouth,United Kingdom

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Department of Leukemia, Division of Cancer Medicine,MD Anderson Cancer Center,Houston,Vereinigte Staaten

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Willamette Valley Cancer Institute and Research Center,Eugene, OR,Estados Unidos

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Hospital De Clinicas de Porto Alegre, Porto Alegre RS, Brazil

  • Levine Cancer Institute,Charlotte, NC,Verenigde Staten

  • Swedish Cancer Institute, Center for Blood Disorders and Stem Cell Transplantation,Seattle, WA,Stati Uniti

  • Department of Leukemia, Division of Cancer Medicine,MD Anderson Cancer Center,Houston,Vereinigte Staaten

  • Somogy County Mór Kaposi General Hospital, Kaposvár, Hungary

  • Department of Haematology,Addenbrooke's Hospital NHS Trust,Cam

  • Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba and CancerCare Manitoba,Winnipeg,Canada

  • University of Colorado Cancer Center,Aurora, CO,Verenigde Staten

  • Peninsula Health and Peninsula Private Hospital, Frankston,Melbourne,Australia

  • University Hospitals Leuven and KU Leuven, Leuven, Belgium

  • Somogy County Mór Kaposi General Hospital, Kaposvár, Hungary

  • Haematology,Haematological Malignancy

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Bobigny

  • Hospital De Clinicas de Porto Alegre, Porto Alegre RS, Brazil

  • Skane University Hospital,Lund,Швеция

  • Lund University Hospital, Lund, Sweden

  • Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d'Hématologie Clinique,Pierre-Bénite,France

  • Sarah Cannon Research Institute and Tennessee Oncology,Nashville, Tennessee,Vereinigte Staaten

  • Hospital De Clinicas de Porto Alegre, Porto Alegre RS, Brazil

  • Peninsula Health and Peninsula Private Hospital, Frankston,Melbourne,Australia

  • Somogy County Mór Kaposi General Hospital, Kaposvár, Hungary

  • University of Colorado Cancer Center, Aurora, CO

  • Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel

  • Swedish Cancer Institute, Center for Blood Disorders and Stem Cell Transplantation,Seattle, WA,Stati Uniti

  • Somogy County Mór Kaposi General Hospital, Kaposvár, Hungary

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Department of Haematology,Addenbrooke's Hospital NHS Trust,Cam

  • Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d'Hématologie Clinique,Pierre-Bénite,France

  • Bobigny: Hématologie biologique, Hopital Avicenne, Université Sorbonne Paris Nord,Bobigny,Francia

  • Somogy County Mór Kaposi General Hospital, Kaposvár, Hungary

  • AstraZeneca, South San Francisco,California,Estados Unidos

  • Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel

  • AstraZeneca, South San Francisco,California,Estados Unidos

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Willamette Valley Cancer Institute and Research Center,Eugene, OR,Estados Unidos

  • Department of Leukemia, Division of Cancer Medicine,MD Anderson Cancer Center,Houston,Vereinigte Staaten

  • Sarah Cannon Research Institute/Tennessee Oncology, Nashville, Tennessee, USA

  • Sarah Cannon Research Institute/Tennessee Oncology, Nashville, Tennessee, USA

  • Department of Haematology,Addenbrooke's Hospital NHS Trust,Cam

  • Department of Haematology,Addenbrooke's Hospital NHS Trust,Cam

  • University of Colorado Cancer Center,Aurora, CO,Verenigde Staten

  • Swedish Cancer Institute, Center for Blood Disorders and Stem Cell Transplantation,Seattle, WA,Stati Uniti

  • AstraZeneca,South San Francisco, CA,United States

  • Levine Cancer Institute,Charlotte, NC,Verenigde Staten

  • AstraZeneca,South San Francisco,Vereinigte Staaten

  • Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d'Hématologie Clinique,Pierre-Bénite,France

  • Maria Sklodow

  • Novant Health Cancer Institute,Charlotte, NC,Estados Unidos

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Hospital De Clinicas de Porto Alegre, Porto Alegre RS, Brazil

  • University of Colorado Cancer Center,Aurora, CO,Verenigde Staten

  • Swedish Cancer Institute, Center for Blood Disorders and Stem Cell Transplantation,Seattle, WA,Stati Uniti

  • Cancer Care, University Hospitals Dorset,Bournemouth,United Kingdom

  • Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba and CancerCare Manitoba,Winnipeg,Canada

  • Peninsula Health and Peninsula Private Hospital, Frankston,Melbourne,Australia

  • Hospital De Clinicas de Porto Alegre, Porto Alegre RS, Brazil

  • University Hospitals (UZ) Leuven,Leuven,Bélgica

  • Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel

  • University Hospitals Leuven and KU Leuven, Leuven, Belgium

  • Willamette Valley Cancer Institute and Research Center,Eugene, OR,Estados Unidos

  • Haematology, Haematological Malignancy Diagnostic Service (HMDS), St. James's Institute of Oncology, Leeds, UK

  • University Hospitals Leuven and KU Leuven, Leuven, Belgium

  • AstraZeneca,South San Francisco,Vereinigte Staaten

  • Novant Health Cancer Institute,Charlotte, NC,Estados Unidos

  • Peni

  • Somogy County Mór Kaposi General Hospital,Ka

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Cancer Care, University Hospitals Dorset,Bournemouth,United Kingdom

  • Sarah Cannon Research Institute and Tenn

  • Willamette Valley Cancer Institute and Research Center,Eugene, OR,Verenigde Staten

  • University of Colorado Cancer Center, Aurora, CO

Locations

  • United States

  • Hungary

  • Poland

  • Brazil

  • United Kingdom

  • Israel

  • Canada

  • Australia

  • Sweden

  • Italy

  • Algeria

  • Belgium

  • France

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Chronic Lymphocytic Leukemia

Biomarkers

  • N/A

Drug/Treatment

  • ACP-196

  • Obinutuzumab

  • Obinutuzumab Intravenous

  • chlorambucil

Outcome

  • N/A

Study Design

  • Randomized

  • Cross Over

Phase

  • N/A

Study Id's

  • NCT02475681

Sponsors

  • N/A

Result

  • N/A

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