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P1293 : COMBINING THE IAP ANTAGONIST, TOLINAPANT, WITH A DNA HYPOMETHYLATING AGENT ENHANCES ANTI-TUMOUR MECHANISMS IN PRECLINICAL MODELS OF T-CELL LYMPHOMA.

Researchers

Presenter

  • Martin Sims

Principal Investigators

  • George Ward

  • Zhiqiang Zhang

  • Simone Jueliger

  • Matthew Davis

  • Adam Boxall

  • Jason Taylor

  • Andrea Biondo

  • John Lyons

  • Tomoko Smyth

Medical Centers

  • Clinical Development,Astex Pharmaceuticals Inc,Pleasanton,Vereinigte Staaten

  • Astex Pharmaceuticals,Cambridge,Royaume-uni

  • Bioinformatics,Astex Pharmaceuticals Limited,Cambridge,Regno Unito

  • Bioinformatics,Astex Pharmaceuticals Limited,Cambridge,Regno Unito

  • Translational Sciences,Astex Pharmaceuticals Limited,Cambridge,Royaume-uni

  • DMPK,Astex Pharmaceuticals Limited,Cambridge,Vereinigtes Königreich

  • Clinical Development,Astex Pharmaceutic

  • Astex Pharmaceuticals,Cambridge,Reino Unido

  • Clinical Development,Astex Pharmaceuticals Inc,Pleasanton,Vereinigte Staaten

  • Astex Pharmaceuticals,Cambridge,Reino Unido

  • Bioinformatics,Astex Pharmaceuticals Limited,Cambridge,Regno Unito

  • DMPK,Astex Pharmaceuticals Limited,Cambridge,Verenigd Koninkrijk

  • Translational Sciences,Astex Pharmaceuticals Limited,Cambridge,United Kingdom

  • Bioinformatics,Astex Pharmaceuticals Limited,Cambridge,United Kingdom

  • Translatio

  • Translational Sciences,Astex Pharmaceuticals Limited,Cambridge,Royaume-uni

  • Clinical Development,Astex Pharmaceuticals Inc,Pleasanton,Vereinigte Staaten

  • Clinical Development,Bellicum Pharmaceuticals, Inc.,Houston, TX,United States

  • Bioinformatics,Astex Pharmaceuticals Limited,Cambridge,Vereinigtes Königreich

  • Translational Sciences,Astex Pharmaceuticals Limited,Cambridge,Royaume-uni

  • Clinical Development,Astex Pharmaceuticals Inc,Pleasanton,Vereinigte Staaten

  • Translational Sciences,Astex Pharmaceuticals Limited,Cambridge,Royaume-uni

  • DMPK,Astex Pharmaceuticals Limited,C

  • Bioinformatics,Astex Pharmaceuticals Limited,Cambridge,Regno Unito

  • DMPK,Astex Pharmaceuticals Limited,Cambridge,United Kingdom

Locations

  • United States

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • T-cell lymphoma

Biomarkers

  • Immunosuppressive acidic protein

  • DNA methyltransferase 1

Drug/Treatment

  • Decitabine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • II

Study Id's

  • NCT02503423

Sponsors

  • N/A

Result

  • N/A

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