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PB1938 : 4WHIM: EVALUATING MAVORIXAFOR, AN ORAL CXCR4 ANTAGONIST, IN PATIENTS WITH WHIM SYNDROME VIA A GLOBAL PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED TRIAL WITH OPEN-LABEL EXTENSION

Researchers

Presenter

  • David C. Dale

Principal Investigators

  • Antoine Azar

  • Raffaele Badolato

  • Yves Bertrand

  • Angela Deya

  • Kathryn E. Dickerson

  • Navid Ezra

  • Henrik Hasle

  • Hyoung Jin Kang

  • Sorena Kiani-Alikhan

  • Taco Kuijpers

  • Alexander Kulagin

  • Daman Langguth

  • Carina Levin

  • Olaf Neth

  • Jane Peake

  • Caroline E. Rutten

  • Anna Shcherbina

  • Teresa K. Tarrant

  • Matthias G. Vossen

  • Christian A. Wysocki

  • Andrea Belschner

  • Diego Cadavid

  • Yanping Hu

  • Honghua Jiang

  • Richard MacLeod

  • Weihua Tang

  • Mike Tillinger

  • Jean Donadieu

Medical Centers

  • Servier Pharmaceuticals,Boston,États-unis

  • Servier Pharmaceuticals LLC,Boston,Verenigde Staten

  • Servier Pharmaceuticals LLC,Boston,Estados Unidos

  • Allergy and Clinical Immunology Department,Hospital Sant Joan de Déu Barcelona, Institut de Recerca Sant Joan de Déu,Barcelona,Spanien

  • Institute of Pediatric Hematology and Oncology (IHOPe), Civil Hospital of Lyon,Lyon,França

  • X4 Pharmaceuticals,Boston,USA

  • Pediatric, Infectious Diseases, Rheumatology and Immunology Department,Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS),Seville,Espagne

  • Department of Hematology,Amsterdam University Medical Center, AMC,Amsterdam,Niederlande

  • Department of Hematology,Amsterdam University Medical Center, AMC,Amsterdam,Niederlande

  • Immunology Department,Sullivan Nicolaides Pathology Auchenflower,Queensland,Австралия

  • Division of Rheumatology and Immunology, Department of Medicine, Duke University,Durham,États-unis

  • Department of Global Health, University of Washington, Seattle, WA, United States

  • Department of Paediatric Immunology, Rheumatology and Infectious Diseases,Amsterdam University Medical Center,Amsterdam,Pays-bas

  • Division of Allergy and Clinical Immunology,Johns Hopkins University,Baltimore,États-unis

  • Allergy and Clinical Immunology Department,Hospital Sant Joan de Déu Barcelona, Institut de Recerca Sant Joan de Déu,Barcelona,Spanien

  • Department of Paediatric Immunology, Rheumatology and Infectious Diseases,Amsterdam University Medical Center,Amsterdam,Pays-bas

  • Department of Pediatrics,Angelo Nocivelli Institute of Molecular Medicine, University of Brescia,Brescia,Italie

  • Department of Hematology,Amsterdam University Medical Center, AMC,Amsterdam,Niederlande

  • Department of Hematology,Amsterdam University Medical Center, AMC,Amsterdam,Niederlande

  • Division of Infectious Diseases and Tropical Medicine, Department of Medicine,Medical University of Vienna,Vienna,Autriche

  • Department of Pediatrics,Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Wide River Institute of Immunology, Seoul National University Children's Hospital,Seoul,Корея, южная

  • Immunology Department,Sullivan Nicolaides Pathology Auchenflower,Queensland,Австралия

  • Department of Pediatrics, Aarhus University Hospital, Skejby, Aarhus, Denmark

  • Pediatric Hematology Unit,Emek Medical Center, Afula and the Ruth and Bruce Rappaport Faculty of Medicine Technion,Haifa,Israël

  • Servier Pharmaceuticals LLC,Boston,Verenigde Staten

  • Institute of Pediatric Hematology and Oncology (IHOPe), Civil Hospital of Lyon,Lyon,França

  • Pediatric, Infectious Diseases, Rheumatology and Immunology Department,Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS),Seville,Espagne

  • Division of Allergy and Immunology, Departments of Pediatrics and Internal Medicine,UT Southwestern Medical Center,Dallas,Vereinigte Staaten

  • Department of Allergy and Immunology,Queensland Children's Hospital, University of Queensland,South Brisbane, Queensland,Австралия

  • Division of Infectious Diseases and Tropical Medicine, Department of Medicine,Medical University of Vienna,Vienna,Autriche

  • Department of Immunology,Barts Health NHS Trust,London,Storbritannien

  • Service d'Hémato-Oncologie Pédiatrique, Hôpital Trousseau,Paris,França

  • Pediatric, Infectious Diseases, Rheumatology and Immunology Department,Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS),Seville,Espagne

  • Department of Immunology,Barts Health NHS Trust,London,Storbritannien

  • Department of Pediatrics, Aarhus University Hospital, Skejby, Aarhus, Denmark

  • Division of Allergy and Immunology, Departments of Pediatrics and Internal Medicine,UT Southwestern Medical Center,Dallas,Vereinigte Staaten

  • Pediatric Hematology Unit,Emek Medical Center, Afula and the Ruth and Bruce Rappaport Faculty of Medicine Technion,Haifa,Israël

  • Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Cancer Research Institute& Wide River Institute of Immunology, Seoul National University Children's Hospital, Seoul, Kyonggi-do, Republic of Korea

  • Division of Allergy and Clinical Immunology,Johns Hopkins University,Baltimore,États-unis

  • Immunology Department,Sullivan Nicolaides Pathology Auchenflower,Queensland,Австралия

  • Department of Hematology,Amsterdam University Medical Center, AMC,Amsterdam,Niederlande

  • Division of Infectious Diseases and Tropical Medicine, Department of Medicine,Medical University of Vienna,Vienna,Autriche

  • Department of Hematology,Amsterdam University Medical Center, AMC,Amsterdam,Niederlande

  • Pediatric Hematology Unit,Emek Medical Center, Afula and the Ruth and Bruce Rappaport Faculty of Medicine Technion,Haifa,Israël

  • Division of Rheumatology and Immunology, Department of Medicine, Duke University,Durham,États-unis

  • Pediatric, Infectious Diseases, Rheumatology and Immunology Department,Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS),Seville,Espagne

  • Department of Immunology,Barts Health NHS Trust,London,Соединённое Королевство

  • RM Gorbacheva Research Institute, Pavlov University,St Petersburg,Russia

  • RM Gorbacheva Research Institute, Pavlov University,St Petersburg,Russia

  • Department of Pediatrics,Angelo Nocivelli Institute of Molecular Medicine, University of Brescia,Brescia,Italie

  • Dmitry Rogachev Research Center of Pediatric Hematology, Oncology and Immunology,

  • Department of Allergy and Immunology,Queensland Children's Hospital, University of Queensland,South Brisbane, Queensland,Австралия

  • Department of Paediatric Immunology, Rheumatology and Infectious Diseases,Amsterdam University Medical Center,Amsterdam,Pays-bas

  • Department of Allergy and Immunology,Queensland Children's Hospital, University of Queensland,South Brisbane, Queensland,Австралия

  • Service d'Hémato-Oncologie Pédiatrique, Hôpital Trousseau,Paris,França

  • Department of Laboratory Medicine, University of Washington, Seattle, WA

  • Allergy and Clinical Immunology Department,Hospital Sant Joan de Déu Barcelona, Institut de Recerca Sant Joan de Déu,Barcelona,Spanien

  • Service d'Hémato-Oncologie Pédiatrique, Hôpital Trousseau,Paris,França

  • Pediatric, Infectious Diseases, Rheumatology and Immunology Department,Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS),Seville,Espagne

  • Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands

  • Division of Rheumatology and Immunology, Department of Medicine, Duke University,Durham,États-unis

  • Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation

  • Pediatric, Infectious Diseases, Rheumatology and Immunology Department,Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS),Seville,Espagne

  • Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Cancer Research Institute& Wide River Institute of Immunology, Seoul National University Children's Hospital, Seoul, Kyonggi-do, Republic of Korea

  • Department of Immunology,Barts Health NHS Trust,London,Storbritannien

  • Dmitry Rogachev Research Center of Pediatric Hematology, Oncology and Immunology,

  • Service d'Hémato-Oncologie Pédiatrique, Hôpital Trousseau,Paris,França

  • Department of Paediatric Immunology, Rheumatology and Infectious Diseases,Amsterdam University Medical Center,Amsterdam,Pays-bas

  • Department of Hematology,Amsterdam University Medical Center, AMC,Amsterdam,Niederlande

  • Department of Immunology,Barts Health NHS Trust,London,Vereinigtes Königreich

  • Division of Rheumatology and Immunology, Department of Medicine, Duke University,Durham,États-unis

  • Department of Hematology,Amsterdam University Medical Center, AMC,Amsterdam,Niederlande

  • Department of Pediatrics, Division of Hematology and Oncology,UT Southwestern Medical Center,Dallas,Verenigde Staten

  • Institute of Pediatric Hematology and Oncology (IHOPe), Civil Hospital of Lyon,Lyon,França

  • Department of Immunology,Barts Health NHS Trust,London,Vereinigtes Königreich

  • Division of Rheumatology and Immunology, Department of Medicine, Duke University,Durham,États-unis

  • Immunology Department,Sullivan Nicolaides Pathology Auchenflower,Queensland,Австралия

  • Service d'Hémato-Oncologie Pédiatrique, Hôpital Trousseau,Paris,França

  • Division of Allergy and Immunology, Departments of Pediatrics and Internal Medicine,UT Southwestern Medical Center,Dallas,Vereinigte Staaten

  • Division of Allergy and Clinical Immunology,Johns Hopkins University,Baltimore,États-unis

  • Department of Immunology,Barts Health NHS Trust,London,Storbritannien

  • Division of Allergy and Immunology, Departments of Pediatrics and Internal Medicine,UT Southwestern Medical Center,Dallas,Vereinigte Staaten

  • Department of Pediatrics, Aarhus University Hospital, Skejby, Aarhus, Denmark

  • X4 Pharmaceuticals,Boston,Stati Uniti

  • Division of Infectious Diseases and Tropical Medicine, Department of Medicine,Medical University of Vienna,Vienna,Autriche

  • X4 Pharmaceuticals,Boston,United States

  • Immunology Department,Sullivan Nicolaides Pathology Auchenflower,Queensland,Австралия

  • Allergy and Clinical Immunology Department,Hospital Sant Joan de Déu Barcelona, Institut de Recerca Sant Joan de Déu,Barcelona,Spanien

  • Department of Paediatric Immunology, Rheumatology and Infectious Diseases,Amsterdam University Medical Center,Amsterdam,Pays-bas

  • Service d'Hémato-Oncologie Pédiatrique, Hôpital Trousseau,Paris,França

  • Department of Pediatrics,Angelo Nocivelli Institute of Molecular Medicine, University of Brescia,Brescia,Italie

  • Dmitry Rogachev Research Center of Pediatric Hematology, Oncology and Immunology,

  • Department of Paediatric Immunology, Rheumatology and Infectious Diseases,Amsterdam University Medical Center,Amsterdam,Pays-bas

  • RM Gorbacheva Research Institute, Pavlov University,St Petersburg,Russia

  • Division of Allergy and Clinical Immunology,Johns Hopkins University,Baltimore,États-unis

  • Department of Pediatrics,Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Wide River Institute of Immunology, Seoul National University Children's Hospital,Seoul,Корея, южная

  • Institute of Pediatric Hematology and Oncology (IHOPe), Civil Hospital of Lyon,Lyon,França

  • Department of Allergy and Immunology,Queensland Children's Hospital, University of Queensland,South Brisbane, Queensland,Австралия

  • Allergy and Clinical Immunology Department,Hospital Sant Joan de Déu Barcelona, Institut de Recerca Sant Joan de Déu,Barcelona,Spanien

  • Department of Pediatrics, Aarhus University Hospital, Skejby, Aarhus, Denmark

  • Division of Allergy and Immunology, Departments of Pediatrics and Internal Medicine,UT Southwestern Medical Center,Dallas,Vereinigte Staaten

  • Division of Allergy and Clinical Immunology,Johns Hopkins University,Baltimore,États-unis

  • Department of Paediatrics,Aarhus University Hospital,Aarhus,Дания

  • Institute of Pediatric Hematology and Oncology (IHOPe), Civil Hospital of Lyon,Lyon,França

  • Institute of Pediatric Hematology and Oncology (IHOPe), Civil Hospital of Lyon,Lyon,França

  • Pediatric, Infectious Diseases, Rheumatology and Immunology Department,Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS),Seville,Espagne

  • Allergy and Clinical Immunology Department,Hospital Sant Joan de Déu Barcelona, Institut de Recerca Sant Joan de Déu,Barcelona,Spanien

  • Division of Rheumatology and Immunology, Department of Medicine, Duke University,Durham,États-unis

  • Division of Allergy and Immunology, Departments of Pediatrics and Internal Medicine,UT Southwestern Medical Center,Dallas,Vereinigte Staaten

  • Department of Allergy and Immunology,Queensland Children's Hospital, University of Queensland,South Brisbane, Queensland,Австралия

  • Department of Paediatric Immunology, Rheumatology and Infectious Diseases,Amsterdam University Medical Center,Amsterdam,Pays-bas

  • Department of Paediatric Immunology, Rheumatology and Infectious Diseases,Amsterdam University Medical Center,Amsterdam,Pays-bas

  • Institute of Pediatric Hematology and Oncology (IHOPe), Civil Hospital of Lyon,Lyon,França

  • Department of Paediatric Immunology, Rheumatology and Infectious Diseases,Amsterdam University Medical Center,Amsterdam,Pays-bas

  • Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Cancer Research Institute& Wide River Institute of Immunology, Seoul National University Children's Hospital, Seoul, Kyonggi-do, Republic of Korea

  • Allergy and Clinical Immunology Department,Hospital Sant Joan de Déu Barcelona, Institut de Recerca Sant Joan de Déu,Barcelona,Spanien

  • Department of Clinical Oncology, Barts Health NHS Trust, London, United Kingdom

  • Service d'Hémato-Oncologie Pédiatrique, Hôpital Trousseau,Paris,França

  • Pediatric Hematology Unit,Emek Medical Center, Afula and the Ruth and Bruce Rappaport Faculty of Medicine Technion,Haifa,Israël

  • Division of Allergy and Immunology, Departments of Pediatrics and Internal Medicine,UT Southwestern Medical Center,Dallas,Vereinigte Staaten

  • Pediatric, Infectious Diseases, Rheumatology and Immunology Department,Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS),Seville,Espagne

  • Division of Rheumatology and Immunology, Department of Medicine, Duke University,Durham,États-unis

  • Division of Allergy and Clinical Immunology,Johns Hopkins University,Baltimore,États-unis

  • Division of Infectious Diseases and Tropical Medicine, Department of Medicine,Medical University of Vienna,Vienna,Autriche

  • Department of Pediatrics, Division of Hematology and Oncology,UT Southwestern Medical Center,Dallas,Verenigde Staten

  • Department of Pediatrics,Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Wide River Institute of Immunology, Seoul National University Children's Hospital,Seoul,Корея, южная

  • RM Gorbacheva Research Institute,Pavlov University,St. Petersburg,Россия

  • Department of Pediatrics, Division of Hematology and Oncology,UT Southwestern Medical Center,Dallas,Verenigde Staten

  • Department of Pediatrics, Aarhus University Hospital, Skejby, Aarhus, Denmark

  • Department of Pediatrics, Division of Hematology and Oncology,UT Southwestern Medical Center,Dallas,Verenigde Staten

  • Department of Pediatrics,Angelo Nocivelli Institute of Molecular Medicine, University of Brescia,Brescia,Italie

  • Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation

  • RM Gorbacheva Research Institute, Pavlov University,St Petersburg,Russia

  • Division of Infectious Diseases and Tropical Medicine, Department of Medicine,Medical University of Vienna,Vienna,Autriche

  • Division of Infectious Diseases and Tropical Medicine, Department of Medicine,Medical University of Vienna,Vienna,Autriche

  • Department of Pediatrics,Angelo Nocivelli Institute of Molecular Medicine, University of Brescia,Brescia,Italie

  • Department of Pediatrics, Aarhus University Hospital, Skejby, Aarhus, Denmark

  • Department of Pediatrics, Division of Hematology and Oncology,UT Southwestern Medical Center,Dallas,Verenigde Staten

  • Division of Allergy and Clinical Immunology,Johns Hopkins University,Baltimore,États-unis

  • Immunology Department,Sullivan Nicolaides Pathology Auchenflower,Queensland,Австралия

  • Allergy and Clinical Immunology Department,Hospital Sant Joan de Déu Barcelona, Institut de Recerca Sant Joan de Déu,Barcelona,Spanien

  • Department of Pediatrics, Division of Hematology and Oncology,UT Southwestern Medical Center,Dallas,Verenigde Staten

  • Department of Allergy and Immunology,Queensland Children's Hospital, University of Queensland,South Brisbane, Queensland,Австралия

  • Department of Pediatrics,Angelo Nocivelli Institute of Molecular Medicine, University of Brescia,Brescia,Italie

  • Department of Pediatrics, Division of Hematology and Oncology,UT Southwestern Medical Center,Dallas,Verenigde Staten

  • Department of Pediatrics,Angelo Nocivelli Institute of Molecular Medicine, University of Brescia,Brescia,Italie

Locations

  • United States

  • Venezuela

  • Spain

  • Italy

  • France

  • Republic of South Korea

  • United Kingdom

  • Russia

  • Australia

  • Israel

  • Austria

  • Republic of South Korea

Companies

  • N/A

Study Components

Therapeutic Area

  • N/A

Disease

  • N/A

Biomarkers

  • C-X-C motif chemokine receptor 4

  • Lymphocyte count

Drug/Treatment

  • AMD-070

Outcome

  • N/A

Study Design

  • Randomized

  • Placebo Control

  • Open Label

  • Controlled

Phase

  • III

Study Id's

  • NCT03005327

  • NCT03995108

Sponsors

  • N/A

Result

  • N/A

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