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P1101 : PIRTOBRUTINIB, A HIGHLY SELECTIVE, NON-COVALENT (REVERSIBLE) BTK INHIBITOR IN PREVIOUSLY TREATED MANTLE CELL LYMPHOMA: UPDATED RESULTS FROM THE PHASE 1/2 BRUIN STUDY

Researchers

Presenter

  • Paolo Ghia

Principal Investigators

  • Steven Le Gouill

  • Manish R. Patel

  • Elisabeth Vandenberghe

  • Wojciech Jurczak

  • Bita Fakhri

  • Yucai Wang

  • Chan Y. Cheah

  • Xuan N. Tan

  • Katharine L. Lewis

  • Mitul Gandhi

  • Christopher Chay

  • Timothy Fenske

  • Catherine C. Coombs

  • Jeff P. Sharman

  • David J. Andorsky

  • Ian Flinn

  • David Lewis

  • Ming Yin

  • Minna Balbas

  • M. Lia Palomba

  • Jennifer Kherani

  • Jennifer A. Woyach

  • John M. Pagel

  • Nicole Lamanna

  • Jonathon B. Cohen

  • Minal A. Barve

  • Pier Luigi Zinzani

  • Chaitra Ujjani

  • Youngil Koh

  • Koji Izutsu

  • Ewa Lech-Maranda

  • Constantine Tam

  • Suchitra Sundaram

  • Binoj Nair

  • Anthony R. Mato

  • Toby A. Eyre

  • Nirav N. Shah

  • Alvaro J. Alencar

  • James N. Gerson

Medical Centers

  • Medical College of Wisconsin ,Milwaukee,Vereinigte Staaten

  • University of Pennsylvania,Philadelphia, PA,Estados Unidos

  • Service d’hématologie clinique du CHU de Nantes, INSERM CRCINA Nantes-Angers, NeXT Université de Nantes, Nantes, France

  • Internal Medicine

  • Winship Cancer Institute, Emory University,Atlanta,États-unis

  • Willamette Valley Cancer Institute and Research Center/US Oncology Research, Eugene, OR

  • Sarah Cannon Research Institute, Nashville, TN

  • Oxford Uni

  • Medical College of WI

  • Messino Cancer Centers ,Asheville,Stati Uniti

  • Institute of Hematology 'Seràgnoli'

  • Internal Medicine,Seoul National University Hospital ,Seoul,Corea del Sud

  • Herbert Irving Comprehensive Cancer Center, New York, NY

  • Institute of Hematology and Transfusion Medicine, Warsaw, Poland

  • Medical College of Wisconsin, Milwaukee,États-unis

  • Mary Crowley Cancer Research,Dallas,États-unis

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Rocky Mountain Cancer Centers, US Oncology Research ,Eugene,United States

  • MD Anderson...

  • Linear Clinical Research and Sir Charles Gairdner Hospital,Perth,Australie

  • Winship Cancer Institute, Emory University,Atlanta,États-unis

  • Linear Clinical Research and Sir Charles Gairdner Hospital,Perth,Australie

  • Virginia Cancer Specialists, Fairfax, VA, United States

  • Hope Directorate St. James Hospital, Dublin,Irlanda

  • Memorial Sloan Kettering Cancer Center,New York ,États-unis

  • Winship Cancer Institute of Emory University,Atlanta, GA,Vereinigte Staaten

  • Medical College of Wisconsin, Milwaukee,États-unis

  • Peter MacCallum Cancer Centre, Royal Melbourne Hospital, and University of Melbourne

  • Fred Hutchinson Cancer Research Center, Seattle, WA, United States

  • Fred Hutchinson Cancer Research Center, Seattle, WA,Seattle, WA,Vereinigte Staaten

  • Mary Crowley Cancer Research,Dallas,United States

  • Loxo Oncology,Stamford,Verenigde Staten

  • Florida Cancer Specialists/Sarah Cannon Research Institute ,Sarasota,Stati Uniti

  • Service d’hématologie clinique du CHU de Nantes, INSERM CRCINA Nantes-Angers, NeXT Université de Nantes, Nantes, France

  • Memorial Sloan Kettering Cancer Center,New York,Vereinigte Staaten

  • Willamette Valley Cancer Institute and Research Center/US Oncology Research, Eugene, OR

  • Messino Cancer Centers ,Asheville,Vereinigte Staaten

  • Memorial Sloan-Kettering Cancer Center, New York, NY, United States

  • Fred Hutchinson Cancer Research Center, Seattle, WA,Seattle, WA,Estados Unidos

  • University of Pennsylvania,Philadelphia, PA,Vereinigte Staaten

  • Hope Directorate St. James Hospital, Dublin,Irlanda

  • University of California, San Francisco, San Francisco, California, United States

  • University of Pennsylvania,Philadelphia,Stati Uniti

  • Herbert Irving Comprehensive Cancer Center, Columbia University ,New York,Vereinigte Staaten

  • Sylvester Comprehensive Cancer Center, Miami, Florida, United States

  • Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center,Oxford,United Kingdom

  • Medical College of Wisconsin, Milwaukee,États-unis

  • Linear Clinical Research and Sir Charles Gairdner Hospital,Perth,Australie

  • Hematology and Medical Oncology,Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai,New York, NY,Vereinigte Staaten

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Loxo Oncology,Stamford,Verenigde Staten

  • Loxo Oncology at Lilly,Stam

  • Mary Crowley Cancer Research,Dallas,États-unis

  • Institute of Hematology, University of Bologna, Bologna, Italy

  • Fred Hutchinson Cancer...

  • Messino Cancer Centers ,Asheville,Stati Uniti

  • University Hospitals Plymouth NHS Foundation Trust,Plymouth,Royaume-uni

  • University of Texas MD Anderson Cancer Center, Houston, Texas, United States

  • Division of Hematology, Mayo...

  • MD Anderson Cancer Center,Houston, TX,Estados Unidos

  • Rocky Mountain Cancer Centers, US Oncology Research ,Eugene,United States

  • National Cancer Center Hospital,...

  • Peter MacCallum Cancer Center, Royal Melbourne Hospital, and University of Melbourne ,Melbourne,Australia

  • University Hospitals Plymouth NHS ,Plymouth,Regno Unito

  • Medical College of Wisconsin, Milwaukee,États-unis

  • Division of Hematology,Mayo Clinic,Rochester,Verenigde Staten

  • Peter MacCallum Cancer Center, Royal Melbourne Hospital, and University of Melbourne ,Melbourne,Australia

  • University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Memorial Sloan Kettering Cancer Center,New York,Vereinigte Staaten

  • Rocky Mountain Cancer Centers, US Oncology Research ,Eugene,United States

  • Linear Clinical Research/Sir Charles Gairdner Hospital, Nedlands, Australia

  • Medical College of Wisconsin ,Milwaukee,Vereinigte Staaten

  • Loxo Oncology,Stamford,Verenigde Staten

  • Hope Directorate St. James Hospital, Dublin,Irlanda

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Internal Medicine,Seoul National University Hospital ,Seoul,South Korea，Republic

  • Linear Clinical Research and Sir Charles Gairdner Hospital,Perth,Australie

  • MD Anderson Cancer Center ,Houston,Verenigde Staten

  • University of North Carolina at Chapel Hill,Chapel Hill,Estados Unidos

  • Division of Hematology, Mayo Clinic,Rochester, MN,États-unis

  • Loxo Oncology,Stamford,Verenigde Staten

  • Peter MacCallum Cancer Center, Royal Melbourne Hospital, and University of Melbourne ,Melbourne,Australia

  • Hope Directorate St. James Hospital, Dublin,Irlanda

  • Neurology, Medical College of Wisconsin, Milwaukee, United States

  • Messino Cancer Centers ,Asheville,Stati Uniti

  • Messino Cancer Centers ,Asheville,Vereinigte Staaten

  • Loxo Oncology at Li

  • Institute of Hematology, University of Bologna, Bologna, Italy

  • Mary Crowley Cancer Research,Dallas,États-unis

  • Medical College of Wisconsin ,Milwaukee,Vereinigte Staaten

  • National Cancer Center Hospital, Tokyo, Japan

  • Florida Cancer Specialists and Research Institute, Sarasota, FL

  • Memorial Sloan Kettering Cancer Center,New York,Vereinigte Staaten

  • National Cancer Center Hospital, Tokyo, Japan

  • University Hospitals Plymouth NHS ,Plymout

  • Fred Hutchinson Cancer Research Center, Seattle, WA,Seattle, WA,Estados Unidos

  • Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center,Oxford,United Kingdom

  • Seoul National University Bundang Hospital,Seongnam,Corée, République De

  • Herbert Irving Comprehensive Cancer Center, Columbia University ,New York,Vereinigte Staaten

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • The Ohio

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Sylvester Comprehensive Cancer Center,Miami,États-unis

  • Institute of Hematology, University of Bologna, Bologna, Italy

  • University of California San Francisco (UCSF),San Francisco ,Estados Unidos

  • Loxo Oncology,Stamford,Verenigde Staten

  • Mary Crowley Cancer Research,Dallas,United States

  • Haematology,University Hospitals Plymouth NHS trust,Plymouth,Verenigd Koninkrijk

  • Division of Hematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY

  • Sylvester Comprehensive Cancer Center,Miami,États-unis

  • Willamette Valley Cancer Institute and Research Center/US Oncology Research, Eugene, OR

  • National Cancer Center Hospital, Tokyo, Japan

  • Messino Cancer Centers ,Asheville,Vereinigte Staaten

  • Loxo Oncology at Lilly ,Stamford,Stati Uniti

  • Florida Cancer Specialists/Sarah Cannon Research Institute,Sarasota,Vereinigte Staaten

  • Memorial Sloan Kettering Cancer Center,New York,Vereinigte Staaten

  • Fred Hutchinson Cancer Research Center, Seattle, WA,Seattle, WA,Estados Unidos

  • Messino Can

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • Virginia Cancer Specialists, Fairfax, VA, United States

  • Sarah Cannon Research Institute, Nashville, TN

  • Haematology,University Hospitals Plymouth NHS trust,Plymouth,Verenigd Koninkrijk

  • Sarah Cannon Research Institute, Nashville, TN

  • National Cancer Center Hospital, Tokyo, Japan

  • Medical College of WI

  • Linear Clinical Res

  • Institute of Hematology and Transfusion Medicine, Warsaw, Poland

  • University of Pennsylvania,Philadelphia, PA,Vereinigte Staaten

  • Herbert Irving Comprehensive Cancer Center, Columbia University ,New York,Vereinigte Staaten

  • Mary Crowley Cancer Research, Dallas, TX, USA

  • Division of Epidemiology, Mayo Clinic, Rochester, United States

  • University of North Carolina at Chapel Hill,Chapel Hill,Estados Unidos

  • Linear Clinical Res

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • Division of Hematology, Mayo Clinic,Rochester, MN,États-unis

  • Virginia Cancer Specialists, Fairfax, VA

  • Sarah Cannon Research Institute, Nashville,United States

  • University of California, San Francisco, San Francisco, CA

  • Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center,Oxford,United Kingdom

  • Memorial Sloan Kettering Cancer Center,New York ,États-unis

  • University of California, San Francisco, San Francisco, CA

  • Rocky Mountain Cancer Centers, US Oncology Research ,Eugene,Vereinigte Staaten

  • Sarah Cannon Research Institute, Nashville,United States

  • National Cancer Center Hospital ,Tokyo,Япония

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • University of California, San Francisco, San Francisco, CA

  • Linear Clinical Research/Sir Charles Gairdner Hospital, Nedlands, Australia

  • Loxo Oncology at Lilly ,Stamford,Stati Uniti

  • Sarah Cannon Research Institute, Nashville,United States

  • Will

  • Universit

  • Medical College of Wisconsin, Milwaukee,États-unis

  • Sylvester Comprehensive Cancer Center,Miami,États-unis

  • Memorial Sloan-Kettering Cancer Center, New York, NY, United States

  • University Hospitals Plymouth NHS ,Plymouth,Regno Unito

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • National Cancer Center Hospital, Tokyo, Japan

  • Institute of Hematology and Transfusion Medicine, Warsaw, Poland

  • Florida Cancer Specialists/Sarah Cannon Research Institute,Sarasota,Vereinigte Staaten

  • Herbert Irving Comprehensive Cancer Center, Columbia University ,New York,Vereinigte Staaten

  • Service d'hématologie clinique du CHU de

  • University of North Carolina at Chapel Hill,Chapel Hill,Estados Unidos

  • Medical College of Wisconsin, Milwaukee,États-unis

  • MD Anderson Cancer Center,Houston, TX,Estados Unidos

  • Winship Cancer Institute of Emory University,Atlanta, GA,Vereinigte Staaten

  • Loxo Oncology,Stamford,Verenigde Staten

  • Institute of Hematology and Transfusion Medicine, Warsaw, Poland

  • Winship Cancer Institute, Emory University,Atlanta,États-unis

  • Hope Directorate St. James Hospital, Dublin,Irlanda

  • Hope Directorate St. James Hospital,

  • Institute of Hematology, University of Bologna, Bologna, Italy

  • Memorial Sloan Ke

  • University of North Carolina, Chapel Hill, NC

  • Medical College of Wisconsin ,Milwaukee,Vereinigte Staaten

  • Maria Sk

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Memorial Sloan Kettering Cancer Center,New York ,États-unis

  • Rocky Mountain Cancer Centers

  • Division of Hematology,Mayo Clinic,Rochester,Verenigde Staten

  • Sylvester Comprehensive Cancer Center ,Miami,Verenigde Staten

  • Sylvester Comprehensive Cancer Center ,Miami,Verenigde Staten

  • Internal Medicine,Seoul National University Hospital ,Seoul,Corea del Sud

  • Rocky Mountain Cancer Centers, US Oncology Research ,Eugene,United States

  • Winship Cancer Institute of Emory University,Atlanta, GA,Vereinigte Staaten

  • Fred Hutchinson Cancer Research Center ,Seattle,Verenigde Staten

  • Memorial Sloan Kettering, NY

  • Virginia Cancer Specialists, Fairfax, VA, United States

  • Division of Hematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Service d’hématologie clinique du CHU de Nantes, INSERM CRCINA Nantes-Angers, NeXT Université de Nantes, Nantes, France

  • Division of Hematology, Mayo Clinic,Rochester, MN,États-unis

  • University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom.

  • University of Pennsylvania,Philadelphia,Stati Uniti

  • Dermatology, University of Pennsylvania, Philadelphia, United States

  • Medical College of Wisconsin, Milwaukee, Wisconsin , United States

  • Institute of He

  • Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center,Oxford,United Kingdom

  • Internal Medicine,Seoul National University Hospital ,Seoul,Corea del Sud

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • Florida Cancer Specialists/Sarah Cannon Research Institute,Sarasota,Vereinigte Staaten

  • University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

  • Sylvester Comprehensive Cancer Ctr.

  • Mary Crowley Cancer Research,Dallas,United States

  • Loxo Oncology at Lilly ,Stamford,Stati Uniti

  • Loxo Oncology at Lilly ,Stamford,Stati Uniti

  • MD Anderson Cancer Center,Houston, TX,Estados Unidos

  • MD Anderson Cancer Center ,Houston,Verenigde Staten

  • Willamette Valley Cancer Institute and Research Center/US Oncology Research, Eugene, OR

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • University of California San Francisco,San Francisco,Verenigde Staten

Locations

  • Italy

  • United States

  • France

  • Ireland

  • Poland

  • United Kingdom

  • Australia

  • Republic of South Korea

  • Japan

  • Republic of South Korea

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Mantle cell lymphoma

Biomarkers

  • Bruton tyrosine kinase

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • Pharmacokinetics

Phase

  • I/II

Study Id's

  • NCT03740529

Sponsors

  • N/A

Result

  • N/A

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