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S147 : PIRTOBRUTINIB, A HIGHLY SELECTIVE, NON-COVALENT (REVERSIBLE) BTK INHIBITOR IN PREVIOUSLY TREATED CLL/SLL: UPDATED RESULTS FROM THE PHASE 1/2 BRUIN STUDY

Researchers

Presenter

  • Anthony R. Mato

Principal Investigators

  • Catherine C. Coombs

  • Nirav N. Shah

  • Nicole Lamanna

  • Talha Munir

  • Ewa Lech-Maranda

  • Toby A. Eyre

  • Jennifer A. Woyach

  • William G. Wierda

  • Chan Y. Cheah

  • Jonathon B. Cohen

  • Lindsey E. Roeker

  • Manish R. Patel

  • Bita Fakhri

  • Minal A. Barve

  • Constantine Tam

  • David Lewis

  • James N. Gerson

  • Alvaro J. Alencar

  • Chaitra Ujjani

  • Ian Flinn

  • Suchitra Sundaram

  • Shuo Ma

  • Deepa Jagadeesh

  • Joanna Rhodes

  • Justin Taylor

  • Omar Abdel-Wahab

  • Paolo Ghia

  • Stephen J. Schuster

  • Denise Wang

  • Binoj Nair

  • Edward Zhu

  • Matthew S. Davids

  • Jennifer R. Brown

  • Wojciech Jurczak

Medical Centers

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Medical College of Wisconsin ,Milwaukee,Vereinigte Staaten

  • Northwell Health Cancer Institute, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health ,New Hyde Park,S

  • Institute of Hematology and Transfusion Medicine, Warsaw, Poland

  • Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center,Oxford,United Kingdom

  • Medical College of WI

  • Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • University of Miami Miller School of Medicine, Miami, Florida, United States

  • Mary Crowley Cancer Research,Dallas,États-unis

  • Medical College of Wisconsin, Milwaukee,États-unis

  • MD Anderson...

  • Linear Clinical Research and Sir Charles Gairdner Hospital,Perth,Australie

  • Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center,Oxford,United Kingdom

  • Memorial Sloan Kettering Cancer Center,New York ,États-unis

  • Winship Cancer Institute of Emory University,Atlanta, GA,Vereinigte Staaten

  • University of Miami Miller School of Medicine, Miami, FL

  • University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

  • Fred Hutchinson Cancer Research Center, Seattle, WA, United States

  • Fred Hutchinson Cancer Research Center, Seattle, WA,Seattle, WA,Vereinigte Staaten

  • Cleveland Clinic,Cleveland ,Vereinigte Staaten

  • Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA

  • Loxo Oncology,Stamford,Verenigde Staten

  • University of Miami Miller School of Medicine, Miami, FL

  • Mary Crowley Cancer Research,Dallas,United States

  • Memorial Sloan Kettering Cancer Center,New York,Vereinigte Staaten

  • Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA

  • Fred Hutchinson Cancer Research Center, Seattle, WA,Seattle, WA,Estados Unidos

  • Memorial Sloan-Kettering Cancer Center, New York, NY, United States

  • University of California, San Francisco, San Francisco, California, United States

  • Cleveland Clinic, Cleveland, United States,

  • Plymouth Hospitals NHS Trust - Derriford Hospital ,Plymouth,Vereinigtes Königreich

  • Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA

  • Medical College of Wisconsin, Milwaukee,États-unis

  • Linear Clinical Research and Sir Charles Gairdner Hospital,Perth,Australie

  • Hematology and Medical Oncology,Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai,New York, NY,Vereinigte Staaten

  • Robert H. Lurie Comprehe

  • Loxo Oncology,Stamford,Verenigde Staten

  • Fred Hutchinson Cancer...

  • Loxo Oncology at Lilly,Stam

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • University of Texas MD Anderson Cancer Center, Houston, Texas, United States

  • Winship Cancer Institute of Emory University,Atlanta, GA,Vereinigte Staaten

  • MD Anderson Cancer Center,Houston, TX,Estados Unidos

  • University of Miami Miller School of Medicine, Miami, FL

  • Medical College of Wisconsin, Milwaukee,États-unis

  • Plymouth Hospitals NHS Trust - Derriford Hospital ,Plymouth,Reino Unido

  • Northwell Health Cancer Institute, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health ,New Hyde Park,S

  • Plymouth Hospitals NHS

  • Plymouth Hospitals NHS Trust - Derriford Hospital ,Plymouth,Reino Unido

  • Sarah Cannon Research Institute, Nashville,United States

  • Memorial Sloan Kettering Cancer Center,New York,Vereinigte Staaten

  • Winship Cancer Institute, Emory University,Atlanta,États-unis

  • Medical College of Wisconsin ,Milwaukee,Vereinigte Staaten

  • Loxo Oncology,Stamford,Verenigde Staten

  • Florida Cancer Specialists/Sarah Cannon Research Institute,Sarasota,Vereinigte Staaten

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Cleveland Clinic, Cleveland, OH

  • Sarah Cannon Research Institute, Nashville,United States

  • MD Anderson Cancer Center ,Houston,Verenigde Staten

  • University of North Carolina at Chapel Hill,Chapel Hill,Estados Unidos

  • Loxo Oncology,Stamford,Verenigde Staten

  • Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center,Oxford,United Kingdom

  • Winship Cancer Institute of Emory University,Atlanta, GA,Vereinigte Staaten

  • Sarah Cannon Research Institute ,Nashville,États-unis

  • St. James University Hospital,Leeds,Vereinigtes Königreich

  • University of North Carolina at Chapel Hill,Chapel Hill,Estados Unidos

  • Neurology, Medical College of Wisconsin, Milwaukee, United States

  • University of North Carolina, Chapel Hill, NC

  • Loxo Oncology at Li

  • Florida Cancer Specialists/Sarah Cannon Research Institute,Sarasota,Vereinigte Staaten

  • Cleveland Clinic,Cleveland,Estados Unidos

  • Northwell Health Cancer Institute, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health ,New Hyde Park,S

  • Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA

  • Ohio State...

  • Memorial Sloan Kettering Cancer Center,New York,Vereinigte Staaten

  • Hemat

  • Fred Hutchinson Cancer Research Center, Seattle, WA,Seattle, WA,Estados Unidos

  • Mary Crowley Cancer Research,Dallas,United States

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Institute of Hematology and Transfusion Medicine, Warsaw, Poland

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Peter MacCallum Cancer Center, Royal Melbourne Hospital, and University of Melbourne ,Melbourne,Australia

  • Loxo Oncology,Stamford,Verenigde Staten

  • University of California San Francisco (UCSF),San Francisco ,Estados Unidos

  • Division of Hematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY

  • Mary Crowley Cancer Research,Dallas,United States

  • Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA

  • University of North Carolina, Chapel Hill, NC

  • Herbert Irving Comprehensive Cancer Center, Columbia University ,New York,Vereinigte Staaten

  • Loxo Oncology at Lilly ,Stamford,Stati Uniti

  • Winshi

  • Fred Hutchinson Cancer Research Center, Seattle, WA,Seattle, WA,Estados Unidos

  • Memorial Sloan Kettering Cancer Center,New York,Vereinigte Staaten

  • Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • Mary Crowley Cancer Research,Dallas,États-unis

  • Plymouth Hospitals NHS Trust - Derriford Hospital ,Plymouth,Reino Unido

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Linear Clinical Res

  • Mary Crowley Cancer Research,Dallas,États-unis

  • Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA

  • Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center,Oxford,United Kingdom

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • Mary Crowley Cancer Research,Dallas,United States

  • University of California, San Francisco, San Francisco, CA

  • Memorial Sloan Kettering Cancer Center,New York ,États-unis

  • University of California, San Francisco, San Francisco, CA

  • Herbert Irving Comprehensive Cancer Center, Columbia University ,New York,Vereinigte Staaten

  • Institute of Hematology and Transfusion Medicine, Warsaw, Poland

  • Peter MacCallum Cancer Center, Royal Melbourne Hospital, and University of Melbourne ,Melbourne,Australia

  • Sarah Cannon Research Institute, Nashville,United States

  • University of California, San Francisco, San Francisco, CA

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Linear Clinical Research/Sir Charles Gairdner Hospital, Nedlands, Australia

  • Loxo Oncology at Lilly ,Stamford,Stati Uniti

  • Herbert Irving Comprehensive Cancer Center, Columbia University ,New York,Vereinigte Staaten

  • Memorial Sloan-Kettering Cancer Center, New York, NY, United States

  • Institute of Hematolo

  • University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Winship Cancer Institute, Emory University,Atlanta,États-unis

  • Herbert Irving Comprehensive Cancer Center,...

  • Cleveland Clinic,Cleveland ,Vereinigte Staaten

  • St. James University Hospital,Leeds,Vereinigtes Königreich

  • University of Miami Miller School of Medicine, Miami, FL

  • MD Anderson Cancer Center,Houston, TX,Estados Unidos

  • Loxo Oncology,Stamford,Verenigde Staten

  • Cleveland Clinic ,Cleveland,États-unis

  • Institute of Hematology and Transfusion Medicine, Warsaw, Poland

  • Memorial Sloan Ke

  • Dana-Farb

  • Peter MacCallum Cancer Center, Royal Melbourne Hospital, and University of Melbourne ,Melbourne,Australia

  • University of Miami Miller School of Medicine ,Miami,Estados Unidos

  • St. James's University Hospital,Leeds,Reino Unido

  • Oxford University

  • Maria Sk

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Memorial Sloan Kettering Cancer Center,New York ,États-unis

  • Winship Cancer Institute, Emory University,Atlanta,États-unis

  • Lymphoma Pro

  • St. James's University Hospital,Leeds,Reino Unido

  • Florida Cancer Specialists/Sarah Cannon Research Institute,Sarasota,Vereinigte Staaten

  • Sarah Cannon Research Institute ,Nashville,Estados Uni

  • Fred Hutchinson Cancer Research Center ,Seattle,Verenigde Staten

  • Florida Cancer Specialists/Sarah Cannon Research Institute,Sarasota,Vereinigte Staaten

  • Memorial Sloan Kettering, NY

  • St. James's University Hospital, Leeds, United Kingdom

  • Division of Hematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY

  • Plymouth Hospitals NHS Trust - Derriford Hospital ,Plymouth,United Kingdom

  • Dana-Farber Cancer Institute, Harvard Medical School ,Boston,Verenigde Staten

  • Florida Cancer Specialists/Sarah Cannon Research Institute,Sarasota,Vereinigte Staaten

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • St James's University Hospital,Leeds,Royaume-uni

  • Peter MacCallum Cancer Centre, Royal Melbourne Hospital, and University of Melbourne

  • Loxo Oncology at Lilly ,Stamford,Stati Uniti

  • Loxo Oncology at Lilly ,Stamford,Stati Uniti

  • MD Anderson Cancer Center,Houston, TX,Estados Unidos

  • Herbert Irving Comprehensive Cancer Center, Columbia University ,New York,Vereinigte Staaten

  • MD Anderson Cancer Center ,Houston,Verenigde Staten

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Cleveland Clinic ,Cleveland,Stati Uniti

  • University of California San Francisco,San Francisco,Verenigde Staten

Locations

  • United States

  • United Kingdom

  • Poland

  • Australia

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • N/A

Disease

  • N/A

Biomarkers

  • Bruton tyrosine kinase

  • Progesterone receptor

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • Pharmacokinetics

Phase

  • I/II

Study Id's

  • NCT03740529

Sponsors

  • N/A

Result

  • N/A

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