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P668 : ACALABRUTINIB VS RITUXIMAB PLUS IDELALISIB OR BENDAMUSTINE IN RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA: ASCEND RESULTS AT ~4 YEARS OF FOLLOW-UP

Researchers

Presenter

  • Paolo Ghia

Principal Investigators

  • Andrzej Pluta

  • Malgorzata Wach

  • Daniel Lysak

  • Martin Simkovic

  • Iryna Kriachok

  • Arpad Illes

  • Javier de la Serna

  • Sean Dolan

  • Philip Campbell

  • Gerardo Musuraca

  • Abraham Jacob

  • Eric Avery

  • Jae Hoon Lee

  • Ganna Usenko

  • Min Hui Wang

  • Ting Yu

  • Wojciech Jurczak

Medical Centers

  • Department of Hematological Oncology, Oncology Spec. Hospital, Brzozow, Poland

  • City Clinical Hospital No. 4 DCC,Dnipro,Украина

  • Nebraska Hematology Oncology,Lincoln,United States

  • Department of Hematooncology and Bone Marrow Transplantation, Medical University of

  • Maria Skłodowska Curie National Research Institute of Oncology,Krakow,Polonia

  • Fakultní Nemocnice Plzen,Pilsen,República Checa

  • AstraZeneca, South San Francisco,California,Estados Unidos

  • Maria Skłodowska Curie National Research Institute of Oncology,Krakow,Polonia

  • Royal Wolverhampton NHS Trust, Wolverhampton, United Kingdom

  • Fakultní Nemocnice Plzen,

  • AstraZeneca,South San Francisco,Vereinigte Staaten

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • AstraZeneca, South San Francisco,California,Estados Unidos

  • City Clinical Hospital No. 4 DCC,Dnipro,Ucrania

  • Department of Hematooncology and Bone Marrow Transplantation, Medical University of

  • Janssen R&D, South San Francisco, California, United States

  • AstraZeneca, South San Francisco,California,Estados Unidos

  • Fakultní Nemocnice Plzen,Pilsen,Tschechische Republik

  • Fakultní Nemocnice Plzen,Pilsen,Tchèque, République

  • University Hospital Hradec Kralove, Charles University,Hradec

  • Barwon Health, University Hospital Geelong,Victoria,Australia

  • Gachon University Gil Medical Center, Incheon, Korea

  • Saint

  • Hospital Universitario Doce de Octubre, Madrid, Spain

  • AstraZeneca,South San Francisco,Vereinigte Staaten

  • Department of Hematological Oncology, Oncology Spec. Hospital, Brzozow, Poland

  • Nebraska Hematology Oncology,Lincoln, Nebraska,Estados Unidos

  • Maria Sklodowska-Curie Institute of Oncology, Warsaw, Poland

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic

  • Barwon Health, University Hospital Geelong,Victoria,Australia

  • Nebraska Hematology Oncology,L

  • University Hospital Hradec Kralove, Charles University,Hradec

  • National Cancer Institute, Kiev, Ukraine

  • Hospital Universitario Doce de Octubre, Madrid, Spain

  • Gachon University Gil Medical Center,Incheon,Corée, République De

  • National Cancer Institute, Kiev, Ukraine

  • Janssen R&D, South San Francisco, California, United States

  • AstraZeneca, South San Francisco,California,Estados Unidos

  • Oncohematology,National Cancer Institute,Kiev,Украина

  • University Hospital Hradec Kralove, Charles University,Hradec

  • Fakultní Nemocnice Plzen,Pilsen,Tschechische Republik

  • Saint John Regional Hospital, University of New Brunswick, New Brunswick, Canada

  • The Royal Wolverhampton NHS Trust,Wolverhampton, UK

  • Hospital Universitario Doce de Octubre, Madrid, Spain

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • National Cancer Institute, Kiev, Ukraine

  • AstraZeneca, South San Francisco,California,Estados Unidos

  • National Cancer Institute, Kiev, Ukraine

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Fakultní Nemocnice Plzen,Pilsen,Чехия

  • Maria Skłodowska Curie National Research Institute of Oncology,Krakow,Polonia

  • University of Debrecen, Faculty of Medicine, Department of Hematology,Debrecen,Ungheria

  • AstraZeneca,South San Francisco,Vereinigte Staaten

  • Hospital Universitario Doce de Octubre, Madrid, Spain

  • AstraZeneca,South San Francisco,Vereinigte Staaten

  • Gachon University Gil Medical Center, Incheon, Korea

  • Nebraska Hematology Oncology,Lincoln, Nebraska,Estados Unidos

  • National Cancer Institute,Kiev,乌克兰

  • Hospital Universitario 12 de Octubre, Madrid,...

  • Gachon University Gil Medical Center, Incheon, Korea

  • City Clinical Hospital No. 4 DCC,Dnipro,Ucrania

  • Hospital Universitario 12 de Octubre, Madrid,...

  • Department of Hematological Oncology, Oncology Spec. Hospital, Brzozow, Poland

  • University of Debrecen, Faculty of Medicine, Departm

  • Nebraska Hematology Oncology,Lincoln, Nebraska,Estados Unidos

  • Barwon Health, University Hospital Geelong,G

  • University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic

  • Fakultní Nemocnice Plzen,Pilsen,Czech

  • The Royal Wolverhampton NHS Trust,Wolverhampton,Verenigd Koninkrijk

  • Department of Hematooncology and Bone Marrow Transplantation, Medical University of

  • Saint John Regional Hospital, University of New Brunswick, New Brunswick, Canada

  • Gachon University Gil Medical Center, Incheon, Korea

  • Saint John Regional Hospital, University of New Brunswick, New Brunswick, Canada

  • Hospital Universitario Doce de Octubre, Madrid, Spain

  • The Royal Wolverhampton NHS Trust,Wolverhampton, UK

  • AstraZeneca, South San Francisco,California,Estados Unidos

  • Gachon University Gil Medical Center,Incheon,Корея, южная

  • City Clinical Hospital No. 4 DCC,Dnipro,Ucrania

  • City Clinical Hospital No. 4 DCC,Dnipro,Ucrania

  • National Cancer Institute, Kiev, Ukraine

  • Hospital Universitario Doce de Octubre, Madrid, Spain

  • Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

  • The Royal Wolverha

  • Nebraska Hematology Oncology,Lincoln, Nebraska,Vereinigte Staaten

  • Fakultní Nemocnice Plzen,Pilsen,República Checa

  • Fakultní Nemocnice Plzen,Pilsen,República Checa

  • Debrecen, University of Debrecen, Faculty of Medicine, Deparment of Clinical Immunology, Debrecen, Hungary

  • Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin,Lublin,Polonia

  • City Clinical Hospital No. 4 DCC,Dnipro,Ucrania

  • Debrecen, University of Debrecen, Faculty of Medicine, Deparment of Clinical Immunology, Debrecen, Hungary

  • The Royal Wolverhampton NHS Trust,Wolverhampton,Verenigd Koninkrijk

  • Department of Hematological Oncology, Oncology Spec. Hospital, Brzozow, Poland

  • AstraZeneca, South San Francisco,California,Estados Unidos

  • University of Debrecen, Faculty of Medicine, Department of Laboratory Medicine, Debrecen, Hungary

  • City Clinical Hospi

  • Barwon Health, University Hospital Geelong,Victoria,Australia

  • The Royal Wolverhampton NHS Trust,Wolverhampton, UK

  • Nebraska Hematology Oncology,Lincoln, Nebraska,Vereinigte Staaten

  • Department of Hematological Oncology, Oncology Spec. Hospital, Brzozow, Poland

  • AstraZeneca, South San Francisco,California,Estados Unidos

Locations

  • Italy

  • Algeria

  • Poland

  • Czech Republic

  • Ukraine

  • Hungary

  • Spain

  • Canada

  • United States

  • Australia

  • United Kingdom

  • Republic of South Korea

  • Republic of South Korea

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Chronic Lymphocytic Leukemia

Biomarkers

  • N/A

Drug/Treatment

  • ACP-196

  • Bendamustine

  • Idelalisib

  • Rituximab

Outcome

  • N/A

Study Design

  • Randomized

  • Open Label

  • Multicenteric

Phase

  • III

Study Id's

  • NCT02970318

Sponsors

  • N/A

Result

  • N/A

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