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P707 : DOSE MODIFICATION DYNAMICS OF PONATINIB IN PATIENTS WITH CHRONIC-PHASE CHRONIC MYELOID LEUKEMIA (CP-CML) FROM THE PACE AND OPTIC TRIALS

Researchers

Presenter

  • Jane Apperley

Principal Investigators

  • Michael Deininger

  • Elisabetta Abruzzese

  • Jorge Cortes

  • Charles Chuah

  • Daniel J. DeAngelo

  • John DiPersio

  • Andreas Hochhaus

  • Jeffrey Lipton

  • Franck Nicolini

  • Javier Pinilla-Ibarz

  • Delphine Rea

  • Gianantonio Rosti

  • Philippe Rousselot

  • Michael Mauro

  • Neil Shah

  • Moshe Talpaz

  • Alexander Vorog

  • Xiaowei Ren

  • Elias Jabbour

Medical Centers

  • Takeda Development Center Americas, Inc. (TDCA),Lexington,United States

  • Research Institute,Tampa, FL,Vereinigte Staaten

  • Georgia Cancer Center at Augusta University,Agusta ,United States

  • Dana-Farber Cancer Institute Boston,Boston,Stati Uniti

  • S Eugenio Hospital, Tor Vergata University, Rome, Italy,

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • Imperial College London,London,Royaume-uni

  • Washington University School of Medicine, St. Louis, MO

  • Universitätsklinikum Jena,Jena,Alemania

  • Memorial Sloan Kettering,New York, NY,Estados Unidos

  • Research Institute,Tampa, FL,Vereinigte Staaten

  • Singapore General Hospital, Duke-NUS Medical Sch

  • Imperial College, London, UK

  • IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori", Meldola, Italy

  • Centre Léon Bérard,Lyon,França

  • Memorial Sloan Kettering,New York, NY,Verenigde Staten

  • Imperial College London,London,Regno Unito

  • S Eugenio Hospital, Tor Vergata University, Rome, Italy,

  • Singapore General Hospital, Duke-NUS Graduate Medical School, Singapore, Singapore

  • Universitätsklinikum Jena,Jena,Alemanha

  • Singapore General Hospital, Duke-NUS Graduate Medical School, Singapore, Singapore

  • Takeda Development Center Americas, Inc.,Lexington,Stati Uniti

  • Hospital Mignot University de Versailles Saint-Quentin-en-Yvelines,Paris,Frankreich

  • Georgia Cancer Center at Augusta University,Agusta ,United States

  • IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori", Meldola, Italy

  • University of Utah-Huntsman Cancer Institute, Salt Lake City, UT

  • S. Eugen

  • Universitätsklinikum Essen,Essen,Германия

  • S Eugenio Hospital, Tor Vergata University, Rome, Italy,

  • University College London,London,Соединённое Королевство

  • Washington University School of Medicine, St. Louis, MO

  • Takeda Development Center Americas, Inc.,Lexington,Stati Uniti

  • Universitatsklinikum Jena, Jena, Germany

  • Dana-Farber Cancer Institute, Boston, MA, United States

  • S Eugenio Hospital, Tor Vergata University, Rome, Italy,

  • S Eugenio Hospital, Tor Vergata University, Rome, Italy,

  • Washington University School of Medicine,St. Louis, MO,Vereinigte Staaten

  • Comprehensive Cancer Center, University of Michigan, Grass Lake, MI

  • Takeda Development Center Americas, Inc.,Lexington,Stati Uniti

  • Hopital St. Louis,Paris,Francia

  • Hopital St. Louis,Paris,Francia

  • University of Texas MD Anderson Cancer Center, Houston, Texas, United States

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • Georgia Cancer Center at Augusta University,Agusta ,United States

  • Singapore General Hospital, Duke-NUS Graduate Medical School, Singapore, Singapore

  • Imperial College London,London,Vereinigtes Königreich

  • Comprehensive Cancer Center, University of Michigan, Grass Lake, MI

  • Dana-Farber Cancer...

  • Hospital Mignot University de Versailles Saint-Quentin-en-Yvelines,Paris,Frankreich

  • Takeda Development Center Americas, Inc.,Lexington,Stati Uniti

  • Memorial Sloan Kettering,New York, NY,Verenigde Staten

  • Universitätsklinikum Jena,Jena,Alemania

  • Memorial Sloan Kettering,New York, NY,Estados Unidos

  • University of Utah-Huntsman Cancer Institute, Salt Lake City, UT

  • Washington University School of Medicine, St. Louis, MO

  • University of Utah and Huntsman Cancer Institute,Salt Lake City,Estados Unidos

  • IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori", Meldola, Italy

  • S Eugenio Hospital, Tor Vergata University, Rome, Italy,

  • University of California, San Francisco, San Francisco, California, United States

  • Georgia Cancer Center, Augusta University, Augusta, GA

  • Comprehensive Cancer Center, University of Michigan, Grass Lake, MI

  • Hospital Mignot University de Versailles Saint-Quentin-en-Yvelines,Paris,Frankreich

  • University of California, San Francisco, San Francisco, CA

  • Dana-Faber Cancer Institute,Boston,Estados Unidos

  • University of Utah-Huntsman Cancer Institute, Salt Lake City, UT

  • Centre Léon Bérard,Lyon,França

  • Washington University in Saint Louis School of Medicine, Saint Louis, Missouri, United States

  • Princess

  • Centre Léon Bérard,Lyon,França

  • Takeda Development Center Americas, Inc.,Lexington,Stati Uniti

  • H. Lee Moffitt Cancer Center

  • Hospital Saint Antoine, Paris, France

  • Hematology,Imperial College of London,London,Verenigd Koninkrijk

  • The University of Tokyo

  • University of California San Francisco,San Francisco,Verenigde Staten

  • Princess Margaret Cancer Center, Toronto, ON, Canada

  • Hospital Mignot University de Versailles Saint-Quentin-en-Yvelines,Paris,Frankreich

  • Georgia Cancer Center, Augusta University, Augusta, GA

  • Comprehensive Cancer Center, University of Michigan, Grass Lake, MI

  • Singapore General Hospital, Duke-NUS Graduate Medical School, Singapore, Singapore

  • Hôpital Saint Antoine,Paris,Франция

  • Hopital St. Louis,Paris,Francia

  • Research Institute,Tampa, FL,Esta

  • University of California, San Francisco, CA

  • Centre Leon Berard,Lyon,Франция

  • Washington University School of Medicine, St. Louis, MO

  • Dana-Farber Cancer Institute, Boston, MA, United States

  • Memorial Sloan Kettering,New York, NY,Verenigde Staten

  • Research Institute,Tampa, FL,États-unis

  • Hopital St. Louis,Paris,Francia

  • Georgia Cancer Center, Augusta University, Augusta, GA

  • Imperial College London,London,Regno Unito

  • Univer

  • University of Utah-Huntsman Cancer Institute, Salt Lake City, UT

  • University of California, San Francisco, San Francisco, CA

  • IRCCS Istituto Romagnolo per lo

  • Hospital Saint Antoine, Paris, France

  • University of California, San Francisco, San Francisco, CA

  • Memorial Sloan Kettering, New York, NY

  • Research Institute,Tampa,Stati Uniti

  • Dana-Farber Cancer Institute, Boston, MA

  • Memorial Sloan Kettering,New York, NY,Estados Unidos

  • IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori", Meldola, Italy

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • Universitatsklinikum Jena, Jena, Germany

  • Centre Léon Bérard,Lyon,França

  • Comprehensive Cancer Center, University of Michigan, Grass Lake, MI

  • Princess Margaret Cancer Center, Toronto, ON, Canada

  • Princess Margaret Cancer Center, Toronto, ON, Canada

  • The University of Texas, MD Anderson Cancer Center,Houston, TX,Verenigde Staten

  • Dana-Farber Cancer Institute, Boston, MA, United States

  • Centre Léon Bérard,Lyon,França

  • NCRI and Imperial College London, London, United Kingdom

  • Centre Leon Berard, Lyon, France

Locations

  • United Kingdom

  • United States

  • Turkey

  • Italy

  • Singapore

  • Germany

  • Canada

  • France

  • Mali

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Chronic Myelogenous Leukemia

Biomarkers

  • Breakpoint Cluster Region

Drug/Treatment

  • Ponatinib

Outcome

  • N/A

Study Design

  • Cohort

Phase

  • II

Study Id's

  • NCT01207440

  • NCT02467270

Sponsors

  • N/A

Result

  • N/A

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