// App-Quantinova.ai

S209 : PRIMARY RESULTS FROM THE PHASE 3 SHINE STUDY OF IBRUTINIB IN COMBINATION WITH BENDAMUSTINE-RITUXIMAB (BR) AND R MAINTENANCE AS A FIRST-LINE TREATMENT FOR OLDER PATIENTS WITH MANTLE-CELL LYMPHOMA

Researchers

Presenter

  • Micahel L. Wang

Principal Investigators

  • Mats Jerkeman

  • Judith Trotman

  • David Belada

  • Carola Boccomini

  • Ian W. Flinn

  • Pratyush Giri

  • Andre Goy

  • Paul A. Hamlin

  • Jos-ngel Hernndez-Rivas

  • Xiaonan Hong

  • Seok Jin Kim

  • David Lewis

  • Yuko Mishima

  • Muhit zcan

  • Guilherme Fleury Perini

  • Christopher Pocock

  • Yuqin Song

  • Stephen E. Spurgeon

  • John M. Storring

  • Jan Walewski

  • Jun Zhu

  • Rui Qin

  • Sanjay Deshpande

  • Angela Howes

  • Steven Le Gouill

  • Martin Dreyling

Medical Centers

  • The Research Institute of the McGill University Health Centre, Montreal, Canada

  • Science University,Portland,Stati Uniti

  • Hospital Israelita Albert Einstein, Sao Paulo, Brazil

  • Department of Hematology, Hôpital Necker, Assistance Publique - Hôpitaux de Paris and Inst

  • Haematology,University Hospitals Plymouth NHS trust,Plymouth,Verenigd Koninkrijk

  • Haematology,University Hospitals Plymouth NHS trust,Plymouth,Verenigd Koninkrijk

  • Science University (OHSU),Portland,Vereinigte Staaten

  • Memorial Sloan Kettering Cancer Center,New York ,États-unis

  • Ankara University School of Medicine,Ankara,Turquía

  • The Research Institute of the McGill University Health Centre, Montreal, Canada

  • John Theurer Cancer Center,Hackensack,Stati Uniti

  • University Hospitals Plymouth NHS Foundation Trust,Plymouth,Royaume-uni

  • Division of Hematology and Oncology, Department of Medicine,Samsung Medical Center, Sungkyunkwan Un

  • Institute (Beijing Cancer Hospital),Beijing,

  • Department of Hematology, Hospital Universitario Infanta Leonor, Universidad Complutense,

  • Fudan University Shanghai Cancer Center, Shanghai, China

  • Sara

  • John Theurer Cancer Center,Hack

  • Concord Repatr

  • Mar

  • Memorial Sloan Kettering Cancer Center,New York,Vereinigte Staaten

  • Concord Repatriation General Hospital, University of Sydney, Sydney, Australia

  • Department of Hematology, Hospital Universitario Infanta Leonor, Universidad Complutense,

  • Sarah Cannon Research Institute and Tennessee Oncology,Nashville,Estados Unidos

  • Hospital Israelita Albert Einstein, Sao Paulo, Brazil

  • Department of Medicine III, Klinikum der Universität München, LMU,Mun

  • Kent & Canterbury Hospital, Kent, United Kingdom

  • Development,Raritan, NJ,Vereinigte Staaten

  • Skane University Hospital and Lund University,Lund,Svezia

  • Department of Internal Medicine III, Klinikum der Universitat Munchen, Munich, Germany

  • Lund University Hospital and Lund University, Lund, Sweden

  • Fourth Department of Internal Medicine - Hematology, Charles University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic

  • Sarah Cannon Research Institute-Tennessee Oncology,Nashville,Stati Uniti

  • Institut Curie comprehensive cancer center, Paris, France

  • Dev

  • University of Texas MD Anderson Cancer Center, Houston, Texas, United States

  • Sarah Cannon Research Institute and Tennessee Oncology,Nashville,Estados Unidos

  • Lund University Hospital and Lund University, Lund, Sweden

  • Fudan University Shanghai Cancer Center, Shanghai, China

  • Department of Pharmacy,The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan

  • Kent and Canterbury Hospital,Canterbury,Reino Unido

  • Royal Adelaide Hospital, Adelaide, Australia

  • Division of Hematology and Medical Oncology, Oregon Health &amp

  • SC Ematologia, AOU Città della Salute e della Scienza di Torino - Presidio Molinette,Torino,Italie

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • Royal Adelaide Hospital, Adelaide, Australia

  • Department of Hematology Oncology,Cancer Institute H

  • Development,Raritan, NJ,Vereinigte Staaten

  • Development,Raritan,United States

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • The University of Texas MD Anderson Cancer...

  • Janssen Research &amp

  • Ankara University School of Medicine,Ankara,Turquía

  • Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute,...

  • The Research

  • Development, LLC,Raritan, NJ,États-unis

  • Fudan University Shanghai Cancer Center, Shanghai, China

  • University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom.

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Memorial Sloan Kettering Cancer Center,New York,Vereinigte Staaten

  • Ankara University School of Medicine,Ankara,Turquía

  • IRCCS Azienda Ospedaliero‐Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna,Bologna,Italia

  • Skane University Hospital and Lund University,Lund,Svezia

  • Hospital Israelita Albert Einstein, Sao Paulo, Brazil

  • Department of Pharmacy,The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan

  • IRCCS Azienda Ospedaliero‐Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna,Bologna,Italia

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Development,Raritan,Stati Uniti

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • Hospitalier Universitaire de Nantes, Centre de Recherche en Cancérologie et Immunologie Nantes Angers, INSERM, Université de Nantes,Nant

  • Ankara University School of Medicine,Ankara,Turquía

  • John Theurer Cancer Center,Hackensack,Stati Uniti

  • Concord Repatriation General Hospital, University of Sydney, Sydney, Australia

  • Ankara University School of Medicine, Pharmacology, Ankara, Turkey

  • Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

  • Development,Raritan,Estados Unidos

  • Royal Adelaide Hospital, Adelaide, Australia

  • Ankara University Faculty of Medicine,

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • Kent and Canterbury Hospital,Canterbury,Royaume-uni

  • Hospitalier Universitaire de Nantes, Centre de Recherche en Cancérologie et Immunologie Nantes Angers, INSERM, Université de Nantes,Nant

  • Department of Medicine III, Klinikum der Universität München, LMU,Mun

  • Sarah Cannon Research Institute-Tennessee Oncology,Nashville,Stati Uniti

  • Lund University Hospital and Lund University, Lund, Sweden

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • IRCCS Azienda Osp

  • Kent and Canterbury Hospital,Canterbury,Reino Unido

  • Royal Adelaide Hospital, Adelaide, Australia

  • Fourth Department of Internal Medicine - Hematology, Charles University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic

  • Skane University Hospital and Lund University,Lund,Svezia

  • Fourth Department of Internal Medicine - Hematology, Charles University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic

  • Department of Internal Medicine III, Klinikum der Universitat Munchen, Munich, Germany

  • Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

  • Memorial Sloan-Kettering Cancer Center, New York, NY, United States

  • Royal Adelaide Hospital,Adelaide,Австралия

  • Maria Sklodow

  • SC Ematologia, AOU Città della Salute e della Scienza di Torino - Presidio Molinette,Torino,Italie

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Royal Adelaide Hospital, Adelaide, Australia

  • Sarah Cannon Research Institute and Tennessee Oncology,Nashville,Estados Unidos

  • Lund University Hospital and Lund University, Lund, Sweden

  • Department of Hematology, Hospital Universitario Infanta Leonor, Universidad Complutense,

  • Department of Hematology, Hospital Universitario Infanta Leonor, Universidad Complutense,

  • John Theurer Cancer Center,Hackensack,Stati Uniti

  • Department of Medicine III, Klinikum der Universität München, LMU,Mun

  • Furman University

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Ankara University School of Medicine,Ankara,Turquía

  • Universit

  • SC Ematologia, AOU Città della Salute e della Scienza di Torino - Presidio Molinette,Torino,Italie

  • Concord Repatriation General Hospital, University of Sydney, Sydney, Australia

  • Memorial Sloan Kettering, NY

  • Institute (Beijing Cancer Hospital),Beijing,

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Kent and Cante

  • Department of Hematology and Oncology, Cancer Institute Hospital, Japanese Foundation For Cancer Research, Tokyo, Japan

  • University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom.

  • The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw,Warsaw,Poland

  • Department of Hematology, Hôpital Necker, Assistance Publique - Hôpitaux de Paris and Institut Imagine, Université de Paris, INSERM UMR1183,Paris,Frankreich

  • SC E

  • Kent and Canterbury Hospital,Canterbury,Vereinigtes Königreich

  • Hospital Israelita Albert Einstein,

  • Ankara University School of Medicine,Ankara,Turquía

  • Department of Leukemia,University of Texas MD Anderson Cancer Center,Houston,Vereinigte Staaten

  • Department of Hematology, Hôpital Necker, Assistance Publique - Hôpitaux de Paris and Institut Imagine, Université de Paris, INSERM UMR1183,Paris,Frankreich

  • Science University,Portland,États-unis

  • Hospital Israelita Albert Einstein, Sao Paulo, Brazil

  • Hospital Israelita Albert Einstein, Sao Paulo, Brazil

  • SC Ematologia, AOU Città della Salute e della Scienza di Torino - Presidio Molinette,Torino,Italie

  • University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom.

  • Hospital Israelita Albert Einstein, Sao Paulo, Brazil

  • Kent and Canterbury Hospital,Canterbury,Vereinigtes Königreich

Locations

  • United States

  • Poland

  • Sweden

  • Canada

  • Australia

  • Italy

  • Czech Republic

  • France

  • Spain

  • China

  • United Kingdom

  • Japan

  • Turkey

  • Germany

  • Republic of South Korea

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Mantle cell lymphoma

Biomarkers

  • N/A

Drug/Treatment

  • Bendamustine

  • Ibrutinib

  • Rituximab

Outcome

  • N/A

Study Design

  • Randomized

  • Placebo Control

Phase

  • III

Study Id's

  • NCT01776840

Sponsors

  • N/A

Result

  • N/A

Copyright © 2026. QuantiNova All rights reserved