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P1042 : SAFETY AND TOLERABILITY RESULTS FROM THE PHASE 3B FREEDOM TRIAL OF FEDRATINIB (FEDR), AN ORAL, SELECTIVE JAK2 INHIBITOR, IN PATIENTS WITH MYELOFIBROSIS (MF) PREVIOUSLY TREATED WITH RUXOLITINIB (RUX)

Researchers

Presenter

  • Vikas Gupta

Principal Investigators

  • Abdulraheem Yacoub

  • Srdan Verstovsek

  • Ruben A. Mesa

  • Claire N. Harrison

  • Giovanni Barosi

  • Jean-Jacques Kiladjian

  • H. Joachim Deeg

  • Salman Fazal

  • Lynda Foltz

  • Ryan J. Mattison

  • Carole B. Miller

  • Christopher Hernandez

  • Jun Zhang

  • Moshe Talpaz

Medical Centers

  • University of Wisconsin Carbone Comprehensive Cancer Center,Madison,Stati Uniti

  • University of Michigan Comprehensive Cancer Center, Ann Arbor, MI

  • Bristol Myers Squibbs,Princeton,Vereinigte Staaten

  • University of Wisconsin Carbone Comprehensive Cancer Center,Madison,Stati Uniti

  • Ascension

  • Fondazione IRCCS Policlinico San Matteo, NICU, Pavia, Italy

  • Avera Cancer Institute,Sioux Falls,United States

  • University of Kansas Medical Center, Kansas City, MO

  • The University of Kansas Cancer Center,Kansas City, KS,Vereinigte Staaten

  • Hôpital Saint-Louis, Université de Paris, INSERM,Paris,Frankrijk

  • University of Kansas Medical Center, Kansas City, MO

  • Guy's and St Thomas' Hospital,London,Reino Unido

  • St. Pauls Hospital, University of British Columbia, Vancouver, BC, Canada

  • Fred Hutchinson Cancer Center, WA.

  • University of Wisconsin Carbone Cancer Center,Madison,États-unis

  • Guy's and St Thomas' Hospital,London,Reino Unido

  • St. Pauls Hospital, University of British Columbia, Vancouver, BC, Canada

  • Bristol Myers Squibb,Princeton,USA

  • Princess Margaret Cancer Centre,...

  • University of Michigan Comprehensive Cancer Center,Ann Arbor, MI,Vereinigte Staaten

  • Avera Cancer Institute,Sioux Falls,États-unis

  • University of Texas MD Anderson Cancer Center, Houston, Texas, United States

  • Fondazione IRCCS Policlinico S

  • Princess Margaret Cancer Center, Toronto, ON, Canada

  • Ascension Saint Agnes Hospital,Baltimore,États-unis

  • St. Pauls Hospital, University of British Columbia, Vancouver, BC, Canada

  • Avera Cancer Institute,Sioux Falls,États-unis

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • Hôpital Saint-Louis, Université de Paris, INSERM,Paris,Frankrijk

  • Ascension Saint Agnes Hospital,Baltimore,États-unis

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • The University of Texas MD Anderson Cancer...

  • Princess Margaret Cancer Center, Toronto, ON, Canada

  • Ascension Saint Agnes Hospital,Baltimore,Verenigde Staten

  • Princess Margaret Cancer Center, Toronto, ON, Canada

  • Hôpital Saint-Louis, Université de Paris, INSERM,Paris,Frankrijk

  • Bristol Myers Squibb,Princeton, NJ,Estados Unidos

  • Fred Hutchinson Cancer Research Center, Seattle, WA,Seattle, WA,Estados Unidos

  • Avera Cancer Institute,Sioux Falls,United States

  • Fondazione IRCCS Policlinico San Matteo, NICU, Pavia, Italy

  • Bristol Myers Squibbs,Princeton,Vereinigte Staaten

  • Fondazione IRCCS Policlinico San Matteo, NICU, Pavia, Italy

  • Guy's and St Thomas' Hospital,London,Vereinigtes Königreich

  • Bristol Myers Squibb,Princeton, NJ,Estados Unidos

  • St. Pauls Hospital, University of British Columbia, Vancouver, BC, Canada

  • Mays Cancer Center at UT Health San Antonio MD Anderson Cencer Center,San Antonio, TX,Stati Uniti

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • The University of Kansas Cancer Center,Kansas City, KS,Vereinigte Staaten

  • Fondazione IRCCS Policlinico San Matteo, NICU, Pavia, Italy

  • University of Michigan Comprehensive Cancer Center, Ann Arbor, MI

  • Mays Cancer Center at UT Health San Antonio MD Anderson Cencer Center,San Antonio, TX,Stati Uniti

  • Hôpital Saint-Louis; Université de Paris; Inserm,Paris,France

  • Princess Margaret Cancer Centre,Toronto,Канада

  • University of Kansas Medical Center, Kansas City, Kansas, United States

  • Guy's and St Thomas' Hospital,London,Vereinigtes Königreich

  • Allegheny Health Network Cancer Institute, Pittsburgh, PA

  • The University of Kansas Cancer Center,Kansas City, KS,Vereinigte Staaten

  • Mays Cancer Institute at UT Health San Antonio MD Anderson,San Antonio,United States

  • Avera Cancer Institute,Sioux Falls,États-unis

  • Allegheny Health Network Cancer Institute,Pittsburgh,Vereinigte Staaten

  • Ave

  • Mays Cancer Cent

  • University of Kansas Medical...

  • Hematology,Fred Hutchinson Cancer Center,Seattle,United States

  • Avera Cancer Institute,Sioux Falls,United States

  • University of Michigan Comprehensive Cancer Center, Ann Arbor, MI

  • University of Michigan Comprehensive Cancer Center, Ann Arbor, MI

  • Fred Hutchinson Cancer Research Center, Seattle, WA,Seattle, WA,Estados Unidos

  • University of Michigan, MI.

  • Bristol Myers Squibb,Summit, NJ,Stati Uniti

  • Ascension Saint Agnes Hospital,Baltimore,Verenigde Staten

  • Fondazione IRCCS Policlinico San Matteo, NICU, Pavia, Italy

  • Mays Cancer Center at UT Health San Antonio MD Anderson Cencer Center,San Antonio, TX,Stati Uniti

  • Guy's and St Thomas' Hospital,London,Royaume-uni

  • Guy's And St Thomas NHS Foundation Trust, London, United Kingdom

  • Hematology,Fred Hutchinson Cancer Center,Seattle,United States

  • Allegheny Health Network Cancer Institute, Pittsburgh, PA

  • Guys and St ThomasHospital, London, UK

  • Allegheny Health Network Cancer Institute, Pittsburgh, PA

  • University of Wisconsin Comprehensive Cancer Center, Madison, WI

  • Allegheny Health Network Cancer Institute, Pittsburgh, PA

  • Hopital Saint-Louis,

  • Allegheny Health Network Cancer Institute,Pittsburgh, Pennsylvania,United States

  • University of Wisconsin Carbone Cancer Center, Madison/WI/US

  • Fondazione IRCCS Policlinico San Matteo, NICU, Pavia, Italy

  • Ascension Saint Agnes Hospital,Baltimore,États-unis

  • Ascension Saint Agnes Hospital,Baltimore,Verenigde Staten

  • Department of Leukemia,University of Texas MD Anderson Cancer Center,Houston,Vereinigte Staaten

  • Fred Hutchinson Cancer Research Center, Seattle, WA,Seattle, WA,Estados Unidos

  • Bristol Meyers Squibb,Princeton,United States

  • Hematology,Fred Hutchinson Cancer Center,Seattle,United States

Locations

  • Canada

  • United States

  • United Kingdom

  • Italy

  • France

  • Ascension

Companies

  • N/A

Study Components

Therapeutic Area

  • Blood/haematological Diseases

  • Oncology (ONC)

  • Central Nervous System (CNS)

Disease

  • Thrombocytopenia

  • Myelofibrosis

  • Hematoma

  • Anemia

Biomarkers

  • N/A

Drug/Treatment

  • Ruxolitinib phosphate

  • Fedratinib

  • Thiamine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • III

Study Id's

  • NCT03755518

Sponsors

  • N/A

Result

  • N/A

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