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S145 : THE COMBINATION OF IBRUTINIB PLUS VENETOCLAX RESULTS IN A HIGH RATE OF MRD NEGATIVITY IN PREVIOUSLY UNTREATED CLL: THE RESULTS OF THE PLANNED INTERIM ANALYSIS OF THE PHASE III NCRI FLAIR TRIAL

Researchers

Presenter

  • Peter Hillmen

Principal Investigators

  • Andrew Pettitt

  • Piers Patten

  • Francesco Forconi

  • Anna Schuh

  • Christopher Fox

  • Nagah Elmusharaf

  • John Gribben

  • Oonagh Sheehy

  • Gavin Preston

  • Dena Howard

  • Anna Hockaday

  • David Cairns

  • Sharon Jackson

  • Nichola Webster

  • Surita Dalal

  • Jane Shingles

  • Kate Cwynarski

  • Shankara Paneesha

  • David Allsup

  • Andrew Rawstron

  • Talha Munir

Medical Centers

  • Worcestershire Acute Hospitals NHS Trust,Worcester,Vereinigtes Königreich

  • Oxford University Hospitals NHS Foundation Trust Oxford UK

  • University of Manchester,Manchester,Regno Unito

  • Belfast City Hospital, Belfast, United Kingdom

  • Roche,Reading,Verenigd Koninkrijk

  • Haematology,University College London,London,Royaume-uni

  • Birmingham Heartlands Hospital,Birmingham,Royaume-uni

  • HMDS,Leeds Cancer Cent

  • Leeds Cancer Research UK Clinical Trials Unit,Leeds Institute of Clinical Trials Research,Leeds,Vereinigtes Königreich

  • Belfast City Hospital,Belfast,Regno Unito

  • Belfast City Hospital,Belfast,Regno Unito

  • Leeds Cancer Research UK Clinical Trials Unit,Leeds Institute of Clinical Trials Research,Leeds,Vereinigtes Königreich

  • Leicester Royal Infirmary Haematology, Leicester, United Kingdom

  • HMDS,Leeds Cancer Centre,Leeds,Соединённое Королевство

  • Castle Hill Hospital,Hull,Соединённое Королевство

  • Aberdeen Royal Infirmary, Aberdeen, United Kingdom

  • HMDS,Leeds Cancer Centre,Leeds,Royaume-uni

  • University of Southampton,

  • Kings College London, London, United Kingdom

  • Leicester Royal Infirmary, Leicester, UK

  • Aberdeen Royal Infirmary,Aberdeen,Regno Unito

  • University College London,London,Reino Unido

  • UK NCRI CLL sub-group,Leeds,Reino Unido

  • HMDS,Leeds Cancer Centre,Leeds,Vereinigtes Königreich

  • Castle Hill Hospital,Hull,Reino Unido

  • Nottingham University Hospitals NHS Trust, Nottingham,

  • Worcestershire Acute Hospitals NHS Trust,Worcester,Regno Unito

  • Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, United Kingdom

  • King's College Hospital,London,Reino Unido

  • Kings College Hospital,London,Verenigd Koninkrijk

  • HMDS,Leeds Cancer Centre,Leeds,Verenigd Koninkrijk

  • Birmingham Heartlands Hospital,Birmingham,United Kingdom

  • Oxford University Hospitals NHS Trust, Oxford,

  • Kings College Hospital,

  • Worcestershire Acute Hospitals NHS Trust,Worcester,United Kingdom

  • University of Manchester,Manchester,Royaume-uni

  • UK NCRI CLL sub-group,Leeds,Verenigd Koninkrijk

  • The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

  • St Bartholomew's Hospital,London,Vereinigtes Königreich

  • Birmingham HeartlandsHospital, Birmingham, UK

  • Aberdeen Royal Infirmary,Aberdeen,Regno Unito

  • Nottinghamshire University Hospitals NHS Trust,Nottingham,Vereinigtes Königreich

  • St Bartholomew's Hospital,London,Royaume-uni

  • University of Manchester,Manchester,Соедин

  • Leicester Royal Infirmary, Leicester, UK

  • Oxford University Hospitals NHS Trust, Oxford, United Kingdom

  • St James's University Hospital,Leeds,Royaume-uni

  • The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

  • University of Manchester,Manchester,Vereinigtes Königreich

  • Haematology,King's College Hospital,London,Соединённое Королевство

  • Belfast City Hospital, Belfast, Ireland

  • Castle Hill Hospital,Hull,Verenigd Koninkrijk

  • Castle Hill Hospital,Hull,Vereinigtes Königreich

  • Clatterbridge Cancer Centre NHS Foundation Trust,Liverpool,Vereinigtes Königreich

  • Leeds Cancer Research UK Clinical Trials Unit,Leeds Institute of

  • Castle Hill Hospital,Hull,Royaume-uni

  • Leicester Royal Infirmary,Leicester,Vereinigtes Königreich

  • Castle Hill Hospital,Hull,Reino Unido

  • Leicester Royal Infirmary,Leicester,Royaume-uni

  • University Hospital of Wales,Cardiff,Verenigd Koninkrijk

  • Belfast City Hospital,Belfast,Соединённое Королевство

  • Roche,Reading,Regno Unito

  • Aberdeen Royal Infirmary,Aberdeen,Royaume-uni

  • Belfast City Hospital,Belfast,Royaume-uni

  • University College London,London,Соединённое Королевство

  • UK NCRI CLL sub-group,Leeds,United Kingdom

  • St. James University Hospital,Leeds,Vereinigtes Königreich

  • University of Southampton, Southampton, UK

  • University College London Hospitals,London,Vereinigtes Königreich

  • University College London,London,Reino Unido

  • Worcestershire Acute Hospitals NHS Trust,Worcester,Vereinigtes Königreich

  • King's College Hospital,London,Reino Unido

  • University Hospital of Wales,Cardiff,Reino Unido

  • UK NCRI CLL sub-group,Leeds,Royaume-uni

  • University of Southampton,Southampton,Vereinigtes Königreich

  • Castle Hill Hospital,Hull,Storbritannien

  • Worcestershire Acute Hospitals NHS Trust,Worcester,Regno Unito

  • St Bar

  • Roche,Reading,Storbritannien

  • Birmingham Heartlands Hospital,Birmingham,Verenigd Koninkrijk

  • Leicester Royal Infirmary,Leicester,Vereinigtes Königreich

  • Nottingham University Hospitals NHS Trust, Nottingham,

  • The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

  • Aberdeen Royal Infirmary,Aberdeen,Vereinigtes Königreich

  • Leeds Cancer Centre, Leeds, United Kingdom

  • UK NCRI CLL sub-group,Leeds,Соединённое Королевство

  • St. James's University Hospital,Leeds,Reino Unido

  • University Hospital of Wales, Cardiff, AK

  • Wales Teaching Hospital,Cardiff,Соединённое Королевство

  • Oxford University Hospitals NHS Trust,Oxford,Vereinigtes Königreich

  • StJamess University Hospital, Leeds, UK

  • Wales Teaching Hospital,Cardiff,Verenigd Koninkrijk

  • St Bartholomew's Hospital,London,Reino Unido

  • Worcestershire Acute Hospitals NHS Trust,Worcester,Regno Unito

  • UK NCRI CLL sub-group,Leeds,Vereinigtes Königreich

  • Oxford University Hospitals NHS Foundation Trust Oxford UK

  • Univer

  • University Hospital of Wales,Cardiff,Reino Unido

  • Belfast City Hospital,Belfast,Verenigd Koninkrijk

  • Wales Teaching Hospital,Cardiff,United Kingdom

  • Wales Teaching Hospital,Cardiff,Vereinigtes Königreich

  • St. James's University Hospital, Leeds, United Kingdom

  • Aberdeen Royal Infirmary,Aberdeen,Соединённое Королевств

  • University of Southampton,Southampton,Vereinigtes Königreich

  • Roche,Reading,Соединённое Королевство

  • Roche,Reading,Vereinigtes Königreich

  • Aberdeen Royal Infirmary,Aberdeen,Verenigd Koninkrijk

  • St Bartholomew's Hospital,London,Reino Unido

  • Leicester Royal Infirmary, Leicester, UK

  • St. James University Hospital,Leeds,Vereinigtes Königreich

  • Birmingham HeartlandsHospital, Birmingham, UK

  • Leeds Cancer Research UK Clinical Trials Unit,Leeds Institute of Clinical Trials Research,Leeds,Vereinigtes Königreich

  • Birmingham Heartlands Hospital,Birmingham,Verenigd Koninkrijk

  • Wales Teaching Hospital,Cardiff,Regno Unito

  • St. James's University Hospital,Leeds,Reino Unido

  • Kings College Hospital,London,Vereinigtes Königreich

  • University of Southampton, Southampten, United Kingdom

  • Nottingham University Hospitals NHS Trust, Nottingham,

  • University Hospital of Wales, Cardiff, United Kingdom

  • Castle Hill Hospital, Driffield, United Kingdom

  • HMDS,Leeds Cancer Centre,Leeds,Reino Unido

  • Oxford University Hospitals NHS Foundation Trust Oxford UK

  • St Bartholomew's Hospital,London,Verenigd Koninkrijk

  • Wales Teaching

  • University of Manchester, Manchester, United Kingdom

  • University of Manchester,Manchester,Regno Unito

  • Wales Teaching Hospital,Cardiff,Regno Unito

  • Oxford University Hospitals NHS Trust,Oxford,Verenigd Koninkrijk

  • University Hospital of Wales,Cardiff,Royaume-uni

  • King's College Hospital,London,Royaume-uni

  • Roche,Reading,United Kingdom

  • Wales Teaching Hospital,Cardiff,Royaume-uni

  • Belfast City Hospital,Belfast,Vereinigtes Königreich

  • St Bartholomew's Hospital,London,Соединённое Королевство

  • Roche,Reading,Royaume-uni

  • UK NCRI CLL sub-group,Leeds,Storbritannien

  • UK NCRI CLL sub-group,Leeds,Reino Unido

  • University College London Hospitals,London,Vereinigtes Königreich

  • Nottingham University City Hospital NHS Trust, Nottingham, United Kingdom

  • University of Southampton,Southampton,Royaume-uni

  • University Hospital of Wales,Cardiff,Verenigd Koninkrijk

  • HMDS,Leeds Cancer Centre,Leeds,Reino Unido

  • Clatterbridge Cancer Centre NHS

  • University of Manchester,Manchester,Verenigd Koninkrijk

  • Kings College London, London, United Kingdom

  • Guy's Hospital, London, United Kingdom

  • University of Southampton, Southampton, UK

  • Nottingham University Hospitals NHS Trust, Nottingham,

  • Roche,Reading,Regno Unito

Locations

  • United Kingdom

  • Turkey

  • United States

  • South Africa

  • Australia

Companies

  • N/A

Study Components

Therapeutic Area

  • N/A

Disease

  • N/A

Biomarkers

  • N/A

Drug/Treatment

  • Venetoclax

  • Ibrutinib

Outcome

  • N/A

Study Design

  • Randomized

  • Controlled

  • Dose Escalation

Phase

  • III

Study Id's

  • ISRCTN01844152

Sponsors

  • N/A

Result

  • N/A

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