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S270 : LONGER-TERM ANALYSIS OF EFFICACY OF LUSPATERCEPT VERSUS PLACEBO IN PATIENTS WITH TRANSFUSION-DEPENDENT BETA-THALASSEMIA ENROLLED IN THE BELIEVE STUDY

Researchers

Presenter

  • Maria Domenica Cappellini

Principal Investigators

  • John B. Porter

  • Kevin H.M. Kuo

  • Thomas D. Coates

  • Ersi Voskaridou

  • Gian Luca Forni

  • Silverio Perrotta

  • Abderrahim Khelif

  • Ashutosh Lal

  • Antonis Kattamis

  • Antonio Piga

  • Olivier Hermine

  • Frederik Lersch

  • Jeevan K. Shetty

  • Sadanand Vodala

  • Jennie Zhang

  • Dimana Miteva

  • Vip Viprakasit

Medical Centers

  • University College London, University College London Hospitals,London,Vereinigtes Königreich

  • Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon

  • Celgene International Sàrl, a Bristol Myers Squibb Company, Boudry, Switzerland

  • Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA

  • University of Turin,Turin,Италия

  • First Department of Radiology, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece

  • Thalassemia and Sickle Cell Center ,Laiko General Hospital,Athens,Grecia

  • Division of Medical Oncology and Hem

  • Fondazione IRCCS Ca' Granda Policlinico Hospital, University of Mila

  • University of California San Francisco Benioff Children's Hospital,Oakland,United States

  • Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA

  • Bristol Myers Squibb,Princeton, NJ,Estados Unidos

  • University College London/University College Hospital London, London, United Kingdom

  • Farhat Hached Teaching Hospital, Sousse University,Sousse,Tunisie

  • Department of Hematology,Hôpital Necker, Assistance Publique Hôpitaux de Paris, University Paris Cité,Paris,Francia

  • University of Turin, Turin, Italy

  • University College London, University College London Hospi

  • University of California Merced,

  • Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon

  • Centro della Microcitemia, Anemie Congenite e Dismetabolismo del Ferro, Ospedale Galliera, Genova, Italy

  • University College London, University College London Hospitals,London,Vereinigtes Königreich

  • Farhat Hached Teaching Hospital, Sousse University,Sousse,Tunisie

  • Department of Hematology,Hôpital Necker, Assistance Publique Hôpitaux de Paris, University Paris Cité,Paris,Francia

  • Celgene International Sàrl, a Bristol Myers Squibb Company, Boudry, Switzerland

  • First Department of Pediatrics

  • Fondazione IRCCS Ca' Granda Maggiore Hospital, University of Milan, Milan, Italy

  • Farhat Hached T

  • Celgene International Sàrl, a Bristol-Myers Squibb Company,Boudry,Suisse

  • Bri

  • Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA

  • Farhat Hached Teaching Hospital, Sousse University,Sousse,Tunisie

  • Farhat Hached Teaching Hospital, Sousse University,Sousse,Tunisie

  • Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica,Università̀ degli Studi della Campania "Luigi Vanvitelli",Napoli,Italie

  • Thalassemia and Sickle Cell Center ,Laiko General Hospital,Athens,Grecia

  • University of Turin, Turin, Italy

  • Fondazione IRCCS Ca' Granda Policlinico Hospital, University of Mila

  • Department of Internal Medicine III ,

  • Thalassemia and Sickle Cell Center ,Laiko General Hospital,Athens,Grecia

  • Siriraj Hospital,Mahidol University,Bangkok,Thaïlande

  • Department of Hematology, Hôpital Necker, Assis

  • Bristol Myers Squibb, Princeton, New Jersey, United States

  • University of Turin, Turin, Italy

  • Centro della Microcitemia, Anemie Congenite e Dismetabolismo del Ferro, Ospedale Galliera, Genova, Italy

  • Fondazione IRCCS Ca' Granda Maggiore Hospital, University of Milan, Milan, Italy

  • Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

  • Celgene International Sàrl, a Bristol Myers Squibb Company, Boudry, Switzerland

  • Farhat Hached Teaching Hospital, Sousse University,Sousse,Tunisie

  • Centro della Microcitemia, Anemie Congenite e Dismetabolismo del Ferro, Ospedale Galliera, Genova, Italy

  • University of Turin, Turin, Italy

  • Bristol Myers Squibb,Princeton, NJ,Estados Unidos

  • Thalassemia and Sickle Cell Center ,Laiko General Hospital,Athens,Grecia

  • First Department of Radiology, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece

  • Children's Center for Cancer and Blood Diseases, Children's Hospita

  • First Department of Radiology, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece

  • University of California San Francisco Benioff Children's Hospital,Oakland,United States

  • Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica,Università̀ degli Studi della Campania "Luigi Vanvitelli",Napoli,Italie

  • Thalassemia and Sickle Cell Ce

  • University of Turin, Turin, Italy

  • Siriraj Hospital Mahidol University, Thailand

  • Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Division of Hematology, Department of Medicine, University of Toronto,Toronto, ON,Canada

  • Siriraj Hospital,

  • Farhat Hached Teaching Hospital, Sousse University,Sousse,Tunisie

  • Siriraj Hospital Mahidol University, Thailand

  • University of Turin, Turin, Italy

  • Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica,Università̀ degli Studi della Campania "Luigi Vanvitelli",Napoli,Italie

  • Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon

  • Bristol Myers Squibbs,Princeton,Vereinigte Staaten

  • Siriraj Hospital Mahidol University, Thailand

  • University of California San Francisco Benioff Children's Hospital,Oakland,United States

  • University of California San Francisco Benioff Children's Hospital,Oakland,United States

  • Bristol Myers Squibbs,Princeton,Vereinigte Staaten

  • Celgene International Sàrl,

  • Celgene International Sàrl, a Bristol Myers Squibb Company, Boudry, Switzerland

  • Fondazione IRCCS Ca' Granda Maggiore Hospital, University of Milan, Milan, Italy

  • First Department of Radiology, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece

  • Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon

  • Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Division of Hematology, Department of Medicine, University of Toronto,Toronto, ON,Canada

  • Centro della Microcitemia e Anemie Congenite e del Dismetabolismo del Ferro,Os

  • Department of Hematology,Hôpital Necker, Assistance Publique Hôpitaux de Paris, University Paris Cité,Paris,Francia

  • Bristol Myers Squibb,Princeton, NJ,Estados Unidos

Locations

  • Italy

  • Lebanon

  • United Kingdom

  • Canada

  • United States

  • Greece

  • Tunisia

  • France

  • Switzerland

  • Thailand

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Ophthalmology (OP)

Disease

  • Beta-thalassemia

Biomarkers

  • Red Blood Cells

Drug/Treatment

  • luspatercept

Outcome

  • N/A

Study Design

  • Randomized

  • Placebo Control

Phase

  • III

Study Id's

  • NCT02604433

Sponsors

  • N/A

Result

  • N/A

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