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S255 : EFFICACY AND SAFETY OF TISAGENLECLEUCEL IN PEDIATRIC AND YOUNG ADULT PATIENTS (PTS) WITH RELAPSED OR REFRACTORY (R/R) MATURE B-CELL NON-HODGKIN LYMPHOMA (NHL): THE PHASE II BIANCA STUDY

Researchers

Presenter

  • Veronique Minard-Colin

Principal Investigators

  • Franco Locatelli

  • Stacy Cooper

  • Joerg Krueger

  • Sara Napolitano

  • Andishe Attarbaschi

  • Andre Baruchel

  • Sara Ghorashian

  • Michelle L. Hermiston

  • Hidefumi Hiramatsu

  • Marianne Ifversen

  • Samuel John

  • Seong Lin Khaw

  • Christine L. Phillips

  • Cristina Diaz de Heredia

  • Daisuke Tomizawa

  • Kim Vettenranta

  • Alan S. Wayne

  • Simon Newsome

  • Rakesh Awasthi

  • Santiago Redondo

  • Aisha Masood

  • Shannon L. Maude

  • Birgit Burkhardt

Medical Centers

  • Great Ormond Street Hospital for Children NHS Trust Haematology Department,London,United Kingdom

  • Cincinnati Children's Hospital Medical Center,Cincinnati, OH,Vereinigte Staaten

  • Cincinnati Children's Hospital Medical Center, Cincinnati, OH

  • Novartis Pharmaceuticals Corporation East Hanover NJ United States

  • Department of Pediatric Hematology and Oncology,Oslo University Hospital,Oslo,Norvegia

  • Hospital Universitario La Paz, Madrid, Spain

  • UT Southwestern Medical Center, Dallas, Texas, United States

  • Department of Pediatrics,Graduate School of Medicine, Kyoto University,Kyoto,Giappone

  • University of Helsinki, H, Finland

  • University Hospital of Helsinki,Helsinki,Finland

  • University of California San Francisco Benioff Children's Hospital,San Francisco, CA,Vereinigte Staaten

  • Department of Pediatric Oncology and Hematology, Essen University Hospital, Essen, Germany

  • Novartis Pharma AG,Basel,Svizzera

  • Hospital Universitari Vall d'Hebron, Vall d'Heb

  • Department of PAediatric Haematology and oncology,

  • Cincinnati Children's Hospital Medical Center, Cincinnati, OH

  • Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca,Barcelona,Espagne

  • Children's Cancer Center, National Center for Chi

  • St. Anna Kinderspital and Children's Cancer Research Institute,Vienna,Österreich

  • Hospital Universitario La Paz, Madrid, Spain

  • Pediatric Haematology and Oncology,University Hospital Muenster,Muenster,Deutschland

  • Pediatric Hematology and Oncology, University Hospital, Muenster, Germany

  • Hospital Universitario La Paz, Madrid, Spain

  • Prinses Maxima Centrum,Utrecht,Paesi Bassi

  • Novartis Farmaceutica S.A.,Madrid,Espanha

  • Department of Pediatric Hematology and Oncology,IRCCS Bambino Gesù Children's Hospital, Sapienza University of Rome,Rome,Italie

  • Kids Cancer Centre, Sydney Childrens Hospital, Randwick, Australia

  • Princess Máxima Centrum,Utrecht,Holanda

  • Novartis Pharmaceuticals Corporation East Hanover NJ United States

  • Children's Hospital Los Angeles, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California,Los Angeles, CA,Vereinigte Staaten

  • UT Southwestern Medical Center, Dallas, Texas, United States

  • University Hospital of Helsinki,Helsinki,Finland

  • Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca,Barcelona,Espagne

  • Princess Máxima Centrum,Utrecht,Holanda

  • Novartis Pharma AG,Basel,Svizzera

  • Childrens Hospital Los Angeles, Saban Research Insititute, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA

  • Novartis Pharmaceutical Corporation, East Hanover, NJ

  • Hospital Universitario La Paz,Madrid,Испания

  • Department of Pediatrics,Graduate School of Medicine, Kyoto University,Kyoto,Giappone

  • Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark

  • St. Anna Kinderspital and Children's Cancer Research Institute,Vienna,Österreich

  • Johns Hopkins Comprehensive Cancer Center,Baltimo

  • University of Texas Southwestern, TX.

  • Department of Pediatric and Adolescent Medicine,

  • Children's Cancer Centre, Royal Children's Hospital, Murdoch Children's Research Institute, Melbourne, Australia

  • Department of Pediatric and Adolescent Oncology,Gustave Roussy, Université Paris-Saclay,Villejuif,France

  • Novartis Pharma Corp, Basel, Switzerland

  • Division of Oncology, Center for Childhood Cancer Research and Cancer Immunotherapy Program, Children's Hospital of Philadelphia, Philadelphia, PA

  • Division of Haematology/Oncology/Bone Marrow Transplantation, Department of Paediatrics,The Hospital for Sick Children,Toronto, ON,Kanada

  • St. Anna Children's Cancer Research Institute, Vienna, Austria

  • Universit

  • Hematology-Oncology and Bone Marrow Transplantation Unit, Pediatric Department, and Monza and Brianza Foundation for Children and their Mums,San Gerardo Hospital,Lombardia, Monza,Italien

  • Novartis Pharma AG,Basel,Zwitserland

  • Cincinnati Children's Hospital Medical Center, Cincinnati, OH

  • Department of Pediatric Hematology and Oncology,Oslo University Hospital,Oslo,Norvegia

  • UT Southwestern Medical Center, Dallas, Texas, United States

  • University Hospital Robert Debré (APHP) and Université de Paris,Paris,Francia

  • Great Ormond Street Hospital for Children NHS Trust Haematology Department,London,United Kingdom

  • Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca,Barcelona,Espagne

  • Novartis Pharma AG,Basel,Svizzera

  • Princess Maxima Center, Utrecht, Netherlands

  • Division of Haematology/Oncology/Bone Marrow Transplantation, Department of Paediatrics,The Hospital for Sick Children,Toronto, ON,Kanada

  • Kids Cancer Centre, Sydney Childrens Hospital, Randwick, Australia

  • Department of Pediatric and Adolescent Oncology, Gustave Roussy,Université Paris

  • Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan

  • Novartis Farmaceutica S.A.,Madrid,Spanien

  • University Hospital Robert Debré (APHP) and Université de Paris,Paris,Francia

  • University of California, San Francisco Childrens Hospital, San Francisco, CA

  • Childrens Cancer Center, National Center of Child Health and Development, Tokyo, Japan

  • Division of Oncology,Center for Childhood Cancer Research and Cancer Immunotherapy Program, Children's Hospital of Philadelphia and Department of Pediatrics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA,États-unis

  • University Hospital Robert Debré (APHP) and Université de Paris,Paris,Francia

  • Novartis Pharmaceutical Corporation, East Hanover, NJ

  • Department of Pediatric Hematology and Oncology,IRCCS Bambino Gesù Children's Hospital, Sapienza University of Rome,Rome,Italie

  • Department of Pediatric and Adolescent Oncology,Gustave Roussy, Université Paris-Saclay,Villejuif,France

  • Children's Cancer Centre, Royal Children's Hospital, Murdoch Children's Research Institute, Melbourne, Australia

  • University of Helsinki,Helsinki,Финляндия

  • Novartis Farmaceutica S.A.,Madrid,Espanha

  • The University of Texas Southwestern Medical Center, Dallas, TX

  • Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca,Barcelona,Espagne

  • Pediatric Hematology and Oncology, University Hospital, Muenster, Germany

  • Hospital Universitario La Paz, Madrid, Spain

  • Children's Cancer Centre, Royal Children's Hospital, Murdoch Children's Research Institute, Melbourne, Australia

  • Prinses Maxima Centrum,Utrecht,Нидерланды

  • Childrens Cancer Center, National Center of Child Health and Development, Tokyo, Japan

  • University of Helsinki,Helsinki,芬兰

  • Princess Máxima Centrum,Utrecht,Holanda

  • Hospital Universitario La Paz, Madrid, Spain

  • University of California, San Francisco Childrens Hospital, San Francisco, CA

  • Novartis Farmaceutica S.A.,Madrid,Spanien

  • Novartis Pharmaceutical Corporation, East Hanover, NJ

  • Division of Haematology/Oncology/Bone Marrow Transplantation, Department of Paediatrics,The Hospital for Sick Children,Toronto, ON,Kanada

  • Princess Máxima Centrum,Utrecht,Holanda

  • Novartis Farmaceutica S.A.,Madrid,Испания

  • Novartis Pharmaceutical Corporation, East Hanover, NJ

  • Department of Clinical Biostatistics, Graduate School of Medicine Kyoto University, Kyoto, Japan

  • Department of Pediatric Hematology and Oncology,IRCCS Bambino Gesù Children's Hospital, Sapienza University of Rome,Rome,Italie

  • Novartis Pharma AG,Basel,Svizzera

  • Cincinnati Children's...

  • Novartis Pharma AG,Basel,Svizzera

  • Childrens Cancer Center, National Center of Child Health and Development, Tokyo, Japan

  • Prinses Maxima Centrum,Utrecht,Paesi Bassi

  • Hematology-Oncology and Bone Marrow Transplantation Unit, Pediatric Department, and Monza and Brianza Foundation for Children and their Mums,San Gerardo Hospital,Lombardia, Monza,Italien

  • The University of Texas Southwestern Medical Center, Dallas, TX

  • Department of Pediatric Hematology and Oncology,Oslo University Hospital,Oslo,Norvegia

  • Children's Hospital Los Angeles, USC Norris Comprehensive Cancer Center, K

  • Hematology-Oncology and Bon

  • Great Ormond Street Hospital for Children NHS Trust Haematology Department,London,United Kingdom

  • Novartis Farmaceutica S.A.,Madrid,Spanien

  • Univer

  • Hospital Universitario La Paz, Madrid, Spain

  • Novartis Farmaceutica S.A.,Madrid,Espanha

  • St. An

  • Kids Cancer Centre, Sydney Children's Hospit

  • Pediatric Hematology and Oncology, University Hospital, Muenster, Germany

  • Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark

  • Great Ormond Street Hospital for Children NHS Trust Haematology Department,London,United Kingdom

  • Pediatric Hematology and Oncology, University Hospital, Muenster, Germany

  • Department of Pediatric and Adolescent Oncology,Gustave Roussy, Université Paris-Saclay,Villejuif,France

  • Novartis Pharmaceuticals AG,Basel,Швейцария

  • Cincinnati Children's Hospital Medical Center, Cincinnati, OH

  • Prinses Maxima Centrum,Utrecht,Paesi Bassi

  • Children's Cancer Centre, Royal Children's

  • Kids Cancer Centre, Sydney Childrens Hospital, Randwick, Australia

  • University of California and San Francisco General Hospital, San Francisco, CA, United States

  • Novartis Farmaceutica S.A.,Madrid,Spanien

  • University Hospital of Helsinki,Helsinki,Finland

  • Great Ormo

  • Hospital Universitario La Paz, Madrid, Spain

  • Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark

Locations

  • France

  • Norway

  • United States

  • Uruguay

  • Spain

  • Netherlands

  • Canada

  • Italy

  • Austria

  • United Kingdom

  • Japan

  • Denmark

  • Australia

  • Ghana

  • Palestine

  • Finland

  • Switzerland

  • Germany

Companies

  • N/A

Study Components

Therapeutic Area

  • Blood/haematological Diseases

  • Oncology (ONC)

  • Genetic Disorder

Disease

  • B-Cell Non-Hodgkin Lymphoma

Biomarkers

  • Cluster of Differentiation 19

Drug/Treatment

  • Cyclophosphamide

  • Cyclophosphamide Injection

  • tisagenlecleucel-t

  • fludarabine tablet

  • Cytarabine liposomal

  • Etoposide

  • Etoposide phosphate

Outcome

  • N/A

Study Design

  • N/A

Phase

  • II

Study Id's

  • NCT03610724

Sponsors

  • N/A

Result

  • N/A

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