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AB0980 (2022) : Hand Osteoarthritis: investigating Pain Effects in a randomised placebo-controlled feasibility study of estrogen-containing therapy (HOPE-e): report on the primary feasibility outcomes

Researchers

Presenter

  • J. A. E. Williams

Principal Investigators

  • M. Chester-Jones

  • A. Francis

  • I. Marian

  • M. Goff

  • G. Brewer

  • M. Gulati

  • L. Eldridge

  • P. Julier

  • C. Minns Lowe

  • V. Barber

  • V. Glover

  • C. Mackworth-Young

  • T. Vincent

  • S. E. Lamb

  • K. Vincent

  • S. J. Dutton

  • F. E. Watt

Medical Centers

  • University of Oxford, Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), Oxford, United Kingdom

  • University of Oxford, Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), Oxford, United Kingdom

  • University of Oxford, Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), Oxford, United Kingdom

  • King’s College London Guy’s Campus, Clinical Trials Unit, London, United Kingdom

  • Oxford University Hospitals NHS Foundation Trust, Physiotherapy Research Unit, Physiotherapy Department, Nuffield Orthopaedic Centre, Oxford, United Kingdom

  • White Horse Medical Practice, Faringdon Medical Centre, Faringdon, United Kingdom

  • Imperial College Healthcare NHS Trust, Rheumatology Department, Charing Cross Hospital, London, United Kingdom

  • University of Oxford, Centre for Rehabilitation Research, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), Oxford, United Kingdom

  • University of Exeter, College of Medicine and Health, Exeter, United Kingdom

  • University of Oxford, Nuffield Department of Women’s and Reproductive Health, Oxford, United Kingdom

  • Imperial College London, Department of Immunology and Inflammation, London, United Kingdom

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Musculoskeletal

Disease

  • Osteoarthritis 2

Biomarkers

  • Albumin/creatinine

Drug/Treatment

  • Conjugated estrogens/bazedoxifene

Outcome

  • N/A

Study Design

  • Randomized

  • Placebo Control

  • Double Blind/Blinded

  • Controlled

  • Parallel Group

Phase

  • N/A

Study Id's

  • ISRCTN12196200

Sponsors

  • Fidia

Result

  • N/A

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