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: Dysregulation of cytochrome P450 oxidoreductase (POR) in NAFLD and hepatocellular carcinoma; evidence from clinical, rodent and cellular models

Researchers

Presenter

  • Ismael da Conceiao

Principal Investigators

  • Nikolaos Nikolaou

  • Laura Gathercole

  • Shelley Harris

  • Niall Dempster

  • Ahmad Moolla

  • Leanne Hodson

  • Jeremy Tomlinson

Medical Centers

  • University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, United Kingdom

  • University of Cambridge, Department of Oncology, Cambridge, United Kingdom

  • Oxford Brookes University, Department of Biological and Medical Sciences, Oxford, United Kingdom

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Endocrine/metabolic Diseases (ME)

  • Oncology (ONC)

  • Gastroenterology (GU)

Disease

  • Nonalcoholic fatty liver disease

  • Liver cancer

  • Fatty Liver Disease

  • Metabolic syndrome

  • Solid malignancies

  • Cirrhosis

  • Obesity

Biomarkers

  • Acetyl-CoA carboxylase

  • AMP-activated protein kinase

Drug/Treatment

  • Memantine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • N/A

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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