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: ACROBAT advance: once daily, oral paltusotine treatment maintained long-term igf-1 at levels previously achieved with injectable long-acting somatostatin receptor ligands (LA-SRLs)

Researchers

Presenter

  • Mnica R Gadelha

Principal Investigators

  • Harpal Randeva

  • Murray B Gordon

  • Emese Mezosi

  • Mirjana Doknic

  • Mikls Tth

  • Cesar L Boguszewski

  • Melissa Nichols

  • Theresa Jochelson

  • Scott Henley

  • Meenal Patel

  • Debbie Koh Mendez

  • Christine Ferrara-Cook

  • Alan Krasner

  • Alessandra Casagrande

  • R Scott Struthers

Medical Centers

  • Neuroendocrinology Research Center/Endocrinology Division, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

  • University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom

  • Allegheny Neuroendocrinology Center, Allegheny General Hospital, Pittsburgh, PA

  • University of Pécs Medical School, 1st Department of Internal Medicine, Hungary

  • Clinical Center of Vojvodina, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Novi Sad, Serbia

  • Semmelweis University, Department of Internal Medicine and Oncology, Hungary

  • SEMPR (Endocrine Division), Department of Internal Medicine, Federal University of Parana, Curitiba, Brazil

  • Crinetics Pharmaceuticals, United States

Locations

  • Brazil

  • United Kingdom

  • United States

  • Hungary

  • Serbia

Companies

  • N/A

Study Components

Therapeutic Area

  • Endocrine/metabolic Diseases (ME)

  • Oncology (ONC)

Disease

  • Neuroendocrine tumors

  • Acromegaly

Biomarkers

  • Protein Tyrosine Phosphatase, Receptor Type F

  • Hemoglobin A1c

  • Insulin-like growth factor 1

Drug/Treatment

  • Somatostatin

  • Cabergoline

  • Lanreotide

  • Octreotide

  • Hydroxyzine

  • Mecasermin

Outcome

  • N/A

Study Design

  • Open Label

  • Multicenteric

Phase

  • II

Study Id's

  • NCT04261712

  • NCT03789656

  • NCT03792555

Sponsors

  • N/A

Result

  • N/A

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