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TPS3144 : A phase 1 study of SGN-B6A, an antibody-drug conjugate targeting integrin beta-6, in patients with advanced solid tumors (SGNB6A-001, Trial in Progress).

Researchers

Presenter

  • Amita Patnaik

Principal Investigators

  • Emiliano Calvo

  • Sarina Anne Anne Piha-Paul

  • Antoine Hollebecque

  • Vladimir Galvao

  • Juanita Suzanne Lopez

  • Fadi S. Braiteh

  • Rachel E. Sanborn

  • Peigen Zhou

  • Natalya N. Nazarenko

  • Afshin Dowlati

Medical Centers

  • START, San Antonio, TX

  • Centro Integral Oncologico Clara Campal- Hospital Madrid Norte Sanchinarro, Madrid, Spain

  • The University of Texas MD Anderson Cancer Canter, Houston, TX

  • Gustave Roussy Cancer Campus, Department of Drug Development (DITEP), Villejuif, France

  • Vall d'Hebron Institute of Oncology, Barcelona, Spain

  • The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom

  • Comprehensive Cancer Centers of Nevada, Las Vegas, NV

  • Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, OR

  • Seagen, Inc., Bothell, WA

  • Seagen, Inc., Bothell, WA

  • Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH

Locations

  • United States

  • Spain

  • France

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Genetic Disorder

Disease

  • Squamous cell carcinoma of the head and neck

  • Non Small Cell Lung cancer

  • Pancreatic cancer

  • Small cell lung cancer

  • Solid malignancies

  • Squamous cell carcinoma

  • Esophageal Cancer

  • Cervical cancer

  • Bladder Cancer

  • Gastric Cancer

  • Gynaecological cancer

  • Breast cancer

  • Lung Cancer

Biomarkers

  • N/A

Drug/Treatment

  • monomethyl auristatin E

Outcome

  • N/A

Study Design

  • Pharmacokinetics

  • Pharmacodynamics

  • Open Label

  • Multicenteric

  • Dose Escalation

  • Cohort

  • First-In-Human

Phase

  • I

Study Id's

  • NCT04389632

Sponsors

  • N/A

Result

  • N/A

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