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TPS11582 : IGNYTE-ESO: A master protocol to assess safety and activity of letetresgene autoleucel (lete-cel; GSK3377794) in HLA-A*02+ patients with synovial sarcoma or myxoid/round cell liposarcoma (Substudies 1 and 2).

Researchers

Presenter

  • Sandra P. D'Angelo

Principal Investigators

  • Fiona Thistlethwaite

  • Albiruni Ryan Abdul Razak

  • Silvia Stacchiotti

  • Warren Allen Chow

  • John B. A. G. Haanen

  • Anna Weinberg Chalmers

  • Steven Ian Robinson

  • Brian Andrew Van Tine

  • Kristen N. Ganjoo

  • Melissa L. Johnson

  • Victoria L. Chiou

  • Thomas H. Faitg

  • Mary Woessner

  • Laura Pearce

  • Aiman Shalabi

  • Jean-Yves Blay

  • George Demetri

Medical Centers

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • Institut D’Hématologie-Oncologie, Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada

  • Canada.

  • The Christie NHS Foundation Trust and University of Manchester, Manchester, United Kingdom

  • Princess Margaret Cancer Centre/Mount Sinai Hospital, Toronto, ON, Canada

  • Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

  • City of Hope Comprehensive Cancer Center, Monrovia, CA

  • Antoni van Leeuwenhoek hospital, Amsterdam, Netherlands

  • Hunstman Cancer Institute of Utah, Salt Lake City, UT

  • Mayo Clinic, Rochester, MN

  • Washington University in St Louis, St. Louis, MO

  • Stanford Univeresity Medical Center, Stanford, CA

  • Sarah Cannon Research Institute, Nashville, TN

  • GlaxoSmithKline, Philadelphia, PA.

  • Centre Leon Berard, Lyon, France

  • Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA

Locations

  • United States

  • Canada

  • United Kingdom

  • Italy

  • Netherlands

  • France

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Synovial sarcoma

  • Liposarcomas

  • Solid malignancies

Biomarkers

  • New York esophageal squamous cell carcinoma 1

  • Major Histocompatibility Complex, Class I, A

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • Pharmacokinetics

  • Single Arm

Phase

  • N/A

Study Id's

  • NCT03967223

Sponsors

  • GlaxoSmithKline (GSK)

Result

  • N/A

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