// App-Quantinova.ai

: Gray Matter Volume and Myelination Assessed by Magnetization Transfer Ratio Predict Disease Progression in Secondary Progressive Multiple Sclerosis: Exploratory Analyses from the EXPAND Study

Researchers

Presenter

  • Robert J. Fox

Principal Investigators

  • Ludwig Kappos

  • Bruce A.C. Cree

  • Gavin Giovannoni

  • Amit Bar-Or

  • Ralf Gold

  • Patrick Vermersch

  • Frank Dahlke

  • Thomas Hach

  • Goeril Karlsson

  • Shannon Ritter

  • Daniela Piani-Meier

  • Douglas L. Arnold

Medical Centers

  • Mellen Center for Treatment and Research in Multiple Sclerosis, Neurological Institute, Cleveland, OH, USA

  • Neurologic Clinic and Policlinic and Research Center for Clinical Neuroimmunology and Neuroscience, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Basel, Switzerland

  • Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA San Francisco CA United States

  • Blizard Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK

  • Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

  • Department for Neurology, St. Josef-Hospital, Ruhr University, Bochum, Germany

  • Univ. Lille, Inserm UMR U1172 LilNCog, CHU Lille, FHU Imminent, Lille, France

  • Novartis AG, Basel, Switzerland

  • Novartis Pharmaceutical Corporation, East Hanover, NJ

  • Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada

  • NeuroRx Research, Montreal, QC, Canada

Locations

  • United States

  • Switzerland

  • United Kingdom

  • Germany

  • France

  • Canada

Companies

  • Novartis AG

Study Components

Therapeutic Area

  • Central Nervous System (CNS)

Disease

  • Multiple Sclerosis

Biomarkers

  • N/A

Drug/Treatment

  • Siponimod

Outcome

  • N/A

Study Design

  • Randomized

  • Placebo Control

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

Copyright © 2026. QuantiNova All rights reserved