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: Inhibition of SDC4-LOX mediated extracellular matrix stiffening prevents chondrocyte differentiation in OA cartilage via increased YAP/TAZ signaling

Researchers

Presenter

  • A. Held

Principal Investigators

  • M. Bollmann

  • U. Hansen

  • T. Pap

  • F. Dell'Accio

  • C. Prein

  • A. Aszodi

  • H. Clausen-Schaumann

  • J. Bertrand

Medical Centers

  • Otto-von-Guericke-Universitat Magdeburg, Magdeburg, Germany

  • Institute of Experimental Musculoskeletal Medicine, Muenster, Germany

  • Centre for Experimental Medicine and Rheumatology, Queen Mary University London, London, United Kingdom

  • The Univ of Western Ontario, London, Canada

  • Experimental Surgery and Regenerative Med., München, Germany

  • Hochschule für angewandte Wissenschaften München FAKULTÄT FÃœR ANGEWANDTE NATURWISSENSCHAFTEN UND MECHATRONIK, München, Germany

Locations

  • Germany

  • United Kingdom

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • N/A

Disease

  • N/A

Biomarkers

  • Connective tissue growth factor

  • Tafazzin

  • Yes Associated Protein 1

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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