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: Significant pain reduction with oral methotrexate in knee osteoarthritis; results from the promote randomised controlled phase iii trial of treatment effectiveness

Researchers

Presenter

  • S.R. Kingsbury

Principal Investigators

  • P. Tharmanathan

  • A. Keding

  • B. Corbacho

  • F.E. Watt

  • D.L. Scott

  • E. Roddy

  • F. Birrell

  • N.K. Arden

  • M.A. Bowes

  • C. Arundal

  • S. Ronaldon

  • L. Vernon

  • C. Hewitt

  • M. Doherty

  • D.J. Torgerson

  • P.G. Conaghan

Medical Centers

  • Leeds Inst. of Rheumatic and Musculoskeletal Med., Univ. of Leeds & NIHR Leeds BioMed. Res. Ctr., Leeds, United Kingdom

  • York Trials Unit, Dept. of Hlth.Sci., Univ. of York, York, United Kingdom

  • Arthritis Res. UK Ctr. for Osteoarthritis Pathogenesis, Kennedy Inst. of Rheumatology, Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal Sci., Univ. of Oxford, Oxford, United Kingdom

  • Kings College London, London, United Kingdom

  • Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom

  • Musculoskeletal Res. Group, Inst. for Cellular Med., Newcastle Univ., Newcastle, United Kingdom

  • Arthritis Res. UK Ctr. for Sports, Exercise and Osteoarthritis, NIHR Musculoskeletal BioMed. Res. Unit, Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal Sci., Nuffield Orthopaedic Ctr., Univ. of Oxford, Oxford, United Kingdom

  • Imorphics, Manchester, United Kingdom

  • Academic Haematology, University of Nottingham, Nottingham, United Kingdom

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Musculoskeletal

Disease

  • Knee osteoarthritis

Biomarkers

  • Nutritional risk screening

  • Albumin/creatinine

Drug/Treatment

  • Methotrexate

Outcome

  • N/A

Study Design

  • Randomized

  • Placebo Control

  • Multicenteric

  • Controlled

  • Dose Escalation

Phase

  • III

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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